Senior Scientist, LC-MS Analytical Development
il y a 4 jours
- Lead analytical development projects using UPLC/UV, UPLC/MS (SQ, Q-Tof), capillary electrophoresis (Agilent and Waters equipment) ensuring the reliability of the results by progressive validation of the methods,
- Perform and manage analysis of oligonucleotides samples and the interpretation of the data by collecting results from different analytical techniques in collaboration with R&D teams,
- Take part to the standardization of lab practices (work instructions, reports, maintenance/ qualification program of the instruments)
- Develop, improve new and existing analytical methods for sample preparation (automation/ liquid handling robot, SPE...), characterization and quantification of product/ impurities by UPLC/MS (low or high resolution), ...
- Ensure the progressive validation of the methods including the methods transfer in collaboration with the QC team,
- Take part to the routine analyses program in medium and high throughput to support the R&D projects (oligonucleotides and key reagents as nucleotides and enzymes),
- Interpret, validate the analytical results using a LIMS,
- Ensure maintenance and verification of the instruments; enforce their performance by standardizing their use (work Instructions; logbooks; system suitability tests),
- Write analytical development protocols and reports,
- Ensure communication with other teams,
- Contribute to the implementation of new techniques or collaborations,
- Guarantee bibliography review and state of the art techniques,
- Participate in the organization of the analytical laboratory
- Minimum Master of Science or equivalent Engineering degree: chemical engineer, biochemist or related, preferably in Analytical chemistry, bio-analyzes,
- At least 5 years of experience in analytical development using LC/MS on biomolecules,
- Mandatory experience in chromatography (UHPLC), High Resolution Mass Spectrometry and associated software
- Excellent communication and interpersonal skills,
- Ability to work independently and within a large multidisciplinary team,
- Dynamic with a positive attitude willing to commit to a high level,
- Good written and verbal communication skills in French and in English
- PhD in Analytical Chemistry
- Experience in the biotech/pharma industry,
- Start-up mindset.
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