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Senior Engineer Biological Image Analysis

Il y a 4 mois


Paris e, France Institut du Cerveau et de la Moelle Épinière Temps plein

**Paris Brain Institute (ICM) is recruiting a**:
**_Senior engineer biological image analysis (M/F) _**

**_As soon as possible _**

**_Permanent (CDI) _**

**_A Paris 13ème _**
- The Paris Brain Institute (ICM) is a private foundation recognized as being of public utility, whose purpose is _
- fundamental and clinical research on the nervous system. On the same site, 700 researchers, engineers and _
- doctors cover all the disciplines of neurology, with the aim of accelerating discoveries on the functioning of the _
- brain and the development of treatments for diseases such as: Alzheimer's, Parkinson's, multiple sclerosis, _
- epilepsy, depression, paraplegia, tetraplegia, etc. _

**POSITION**
- Context _

The Paris Brain Institute is investing in cutting-edge technologies and expertise as part of its transversal
approach to the discovery of new treatments for neurological diseases. The Data Analysis Core facility (DAC)
mission within this ambitious program is to develop new tools and analyses, coordinate FAIR data governance
across the institute, and accompany researchers in exploiting the full potential of the institute’s technology and
data ecosystem. The DAC consists of an enthusiastic interdisciplinary team of experts in biostatistics,
bioinformatics, computational neuroscience, and data management. We accompany researchers throughout
the research cycle, from idea to publication. We perform analyses, develop databases, and offer training in data
analysis and good practices in data management. We are currently recruiting new team members to strengthen
our expertise in bioinformatics (spatial transcriptomics), image analysis using deep learning (microscopy,
histology, and neuroimaging), and research data governance. If you are interested in the brain and want to
- Job description (mission) _
- Development of advanced image analysis algorithms for the analysis of (histological) images from

electron and photon microscopes
- Translation of research questions regarding image analysis, including preprocessing, segmentation,

classification and reporting of (statistical) features
- Integrating and automatizing image analysis as part of our NGS bioinformatics pipelines
- Coordination and participation in transversal projects together with the histology platform (Histomics),

the sequencing platform (iGenSeq), the neuroimaging facility (CENIR) and research teams throughout
the institute
- Coordination and collaboration on image analyses across the institute
- Investigate and respond to the needs of the institute regarding image analyses, providing scientific and

strategic advice of the highest scientific ambition
- Document and teach image analysis

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**PROFILE**
- Know-how (savoir-faire) _
- Fluency in manipulation, visualization and conversion of images, including high-res (pyramidal) formats
- Deep understanding of deep learning / machine learning / AI procedures in biological image analysis,

including cell segmentation and differentiation (2D and 3D), detection of co-localization, morphological
studies, temporal tracking of objects over time, and visualization and interaction with high-res
(pyramidal) images

CellPose is desired but not required
- Experience with spatial transcriptomics technology, such as Visium (10X Genomics), GeoMX DSP

(Nanostring) or Merscope (Vizgen) is desired but not required
_Knowledge (savoir) _
- PhD in computer science/biostatistics/bio-informatics with a focus on machine learning in

(biological/medical) image analysis
- Image analysis in Python (required) and R/MATLAB/C/C++ (highly desired)
- Project management using Gitlab
- Soft skills (savoir-être) _
- Autonomy to quickly learn new methods adapted to the wide variety of data
- Ability to integrate into a multi-disciplinary team with team spirit, and a collaborative working style_ _
- Ability to communicate with researchers and staff from different scientific/clinical backgrounds_ _
- Strong organizational, project management and communication skills_ _
- Excellent interpersonal skills
- Excellent command of academic English
- Conversational French desired but not required

Please send your CV and letter of motivation (in English), indicating name and contact details of two

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