Scientific Researcher
il y a 4 semaines
Mission
Scientific context
Exposure to ionizing radiation (IR) during childhood is a recognized risk factor for the development of cancers. However, the impact of low doses on public health remains unclear. To address this question, we are developing an organoid model of human normal thyroid tissue, which reproduces the 3D organization of thyroid follicles and synthesizes thyroid hormone.
Work context and objectives
We are seeking a researcher to analyze the response of these organoids to low doses of IR. The candidate will be involved in the development of protocols to explore the oxidative status of the organoids after exposure, including the analysis of key signaling pathways, mitochondrial function, and reactive oxygen species production.
Key responsibilities
- Develop and implement protocols for the analysis of organoid response to IR
- Collaborate with the laboratory of T. Pourcher to develop metabolomic approaches
- Monitor the long-term maintenance of thyrospheres in culture and analyze their response to IR
Requirements
- PhD in molecular and cellular biology
- Experience in cell culture and knowledge of molecular mechanisms of cellular response to genotoxic stress
Additional information
The position will be located at the Institute for Radiological Protection and Nuclear Safety (IRSN) in France. Salary will be based on qualifications and experience according to the IRSN salary grid.
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