Senior Scientist

Il y a 6 mois


SoisysurSeine, France Kyron.bio Temps plein

Description poste

We are seeking a highly skilled, entrepreneurial-minded CHO cell line development expert. You will be responsible for the execution of feasibility studies for industry partners, test different genetic integration strategies in CHO cells, and optimise growth conditions. The ideal candidate will be a creative thinker who is not afraid to think outside the box, with a strong industrial grounding, and excellent leadership and communication skills.

Roles and responsibilities:

• Be the driving force behind the development of stable mammalian cell lines expressing key therapeutic proteins of interest (both transiently and stably)
• Lead the optimisation and development of CHO cell medium for engineered cell lines, coordinating with third parties where required
• Adapt CHO cells to serum-free and suspension growth
• Explore and optimise gene expression in both CHO and HEK cells (testing different promoters, UTR’s, etc)
• Optimise & scale up growth of different CHO cell lines
• Quality reporting of cell banks
• Contribute to set up and development of in house analytical studies
• Take on managerial responsibilities as the team grows, contributing to growth and recruitment of a fast-growing R&D team

Description profil

Skills and requirements:

• Minimum 3 years relevant industry experience working with cell line development
• PhD in cell and molecular biology, biochemistry, biological engineering, or other life science discipline (exceptional Masters students with extensive industry experience will be considered) • Experience in suspension CHO/HEK cell line development; Vector design/Cloning; Stable and transient transfections; Single cell cloning; Clone selection (ELISA/Octet); Research Cell Banking (RCB) generation; Stability Assessment Studies; Genetic characterization methods (qPCR, whole genome sequencing)
• Experience leading projects or project sub teams and/or managing contract research relationships
• Excellent planning and organisation skills
• Team player who can deliver projects in a timely manner, yet work independently when needed
• Someone who wants to push the boundaries of scientific knowledge and tackle things they have never done before (or no one has)
• A creative thinker with an entrepreneurial, problem-solving mindset
• Fluency in English

Bonus skills:

• Knowledgeable about GMP and regulatory requirements
• Postdoctoral studies
• Experience working with glycoproteins and/or the protein secretory pathway
• Mass spectrometry experience
• Patent inventor
• Experience working with plant and yeast recombinant expression systems
• French language

Poste proposé

Intitulé du poste proposé
Kyron.bio – Senior Scientist – CHO cell line development

Poste basé à  Paris

Secteur d’activité : Biotechnology

Nature du contrat :  CDI


  • Analytical Scientist H/F- CDI

    il y a 4 semaines


    Soisy-sur-Seine, Île-de-France Nutropy Temps plein

    Description of the Position / MissionAt Nutropy, we are seeking an analytical scientist to join our team. The successful candidate will be responsible for developing and validating analytical methods, particularly in liquid chromatography, in collaboration with senior scientists.Key Responsibilities:Develop and validate analytical methods for liquid...


  • Soisy-sur-Seine, France Nutropy Temps plein

    Description du poste / mission At Nutropy, your job will consist in: Be in charge of analytical development and validation, particularly in liquid chromatography, working hand-in-hand with senior scientists Perform routine analysis Write analytical documentation in English (protocols, reports) Participate in strategic discussions with the...

  • Senior PBPK Modeller

    il y a 4 semaines


    Soisy-sur-Seine, Île-de-France PhinC Temps plein

    PhinC Development is seeking a highly skilled Senior Pharmacométricien to join its team in Massy, France.As a leader in the field of drug development, PhinC is involved in various areas where the use of Physiologically Based Pharmacokinetics (PBPK) models has gained significant interest.In this role, you will be part of a dedicated team of 3 scientists...

  • Data Scientist Senior

    Il y a 5 mois


    Le Bar-sur-Loup, France Mane Temps plein

    Notre MANE Digital Factory est actuellement à la recherche d'un senior data scientist pour nous aider à mettre en place notre stratégie de MLOps et transformer les vastes ensembles de données à notre disposition en valeur tangible pour nos clients. En tant que membre de la Digital Factory, vous passerez du temps à travailler de manière transversale...

  • Senior PBPK Modeling Expert

    il y a 4 semaines


    Soisy-sur-Seine, Île-de-France PhinC Temps plein

    Job Description:PhinC Development is seeking a senior pharmacometrician with expertise in Physiologically Based Pharmacokinetics (PBPK) modeling to join our team. In the context of drug development, PBPK models have gained significant interest and are a valuable tool for modeling and simulating drug-drug interaction (DDI) studies of various molecules and...

  • PBPK Modeler

    Il y a 6 mois


    Soisy-sur-Seine, France PhinC Temps plein

    Description poste PhinC Development has an opening position for a senior pharmacometrician specialized in Physiologically Based Pharmacokinetics (PBPK) modeling. In the context of drug development, the use of PBPK models has gained significant interest and is a useful tool which allows the modeling and simulation of drug-drug interaction (DDI)...

  • Senior Data Scientist

    il y a 1 semaine


    Asnières-sur-Seine, 92600, Nanterre, France Dataiku Temps plein

    At Dataiku, we're not just adapting to the AI revolution, we're leading it. Since our beginning in Paris in 2013, we've been pioneering the future of AI with a platform that makes data actionable and accessible. With over 1,000 teammates across 25 countries and backed by a renowned set of investors, we're the architects of Everyday AI,...


  • Seine-Saint-Denis, France Ministère de l-Économie, des Finances et de la Souveraineté industrielle et numérique Temps plein

    Description du poste La DGFiP développe sa stratégie IA autour de la consolidation de ses capacités de mise à l'échelle pour ses cas d'usages. Elle souhaite notamment: • Favoriser, centraliser & standardiser l’accès à ces technologies pour tous les agents et les applications de la DGFiP • Faciliter les traitements de données nécessitant...

  • Data Scientist Senior Banque

    il y a 4 semaines


    Neuilly-sur-Seine, Île-de-France Groupe Demeter Temps plein

    Le Groupe DEMETER est un cabinet de recrutement spécialisé dans la transformation et l'innovation. Nous recherchons des consultants seniors pour renforcer nos expertises Data.Nos clients sont des groupes de conseil en transformation, management et stratégie français indépendants. Ils accompagnent leurs clients sur leurs grands projets de transformation...

  • Data Scientist Senior

    Il y a 6 mois


    Neuilly-sur-Seine, France Groupe Demeter Temps plein

    Le Groupe DEMETER est un cabinet de recrutement fondé par quatre Ingénieurs et Business Managers ayant la même passion pour la transformation, l'innovation et le management d’équipe. Notre client est un groupe de conseil en transformation, management et stratégie français indépendant. Il accompagne ses clients sur leur grands projets de...

  • Client Dedicated

    Il y a 6 mois


    Ivry-sur-Seine, France Thermo Fisher Scientific Temps plein

    Client Dedicated - Sr Scientist - Bioanalytics Thermo Fisher's clinical research business is a leading global contract research organization and world leader in serving science. We are passionate, deliberate, and driven by our mission - to enable our customers to make the world healthier, safer, and cleaner. Within our Analytical Services team, we have a...


  • Neuilly-sur-Seine, France Groupe Demeter Temps plein

    Le Groupe DEMETER est un cabinet de recrutement fondé par quatre Ingénieurs et Business Managers ayant la même passion pour la transformation, l'innovation et le management d’équipe. Notre client est un groupe de conseil en transformation, management et stratégie français indépendant. Il accompagne ses clients sur leurs grands projets de...

  • Cell Line Development Expert

    il y a 2 semaines


    Soisy-sur-Seine, Île-de-France Kyron Temps plein

    Senior Scientist Opportunity at Kyron.bioWe are seeking a highly skilled Cell Line Development expert to join our team at Kyron.bio in Paris. The ideal candidate will have a strong background in cell biology, excellent leadership and communication skills, and the ability to think creatively.About the Role:Lead the development of stable mammalian cell lines...


  • Neuilly-sur-Seine, France Groupe Demeter Temps plein

    Le Groupe DEMETER est un cabinet de recrutement fondé par quatre Ingénieurs et Business Managers ayant la même passion pour la transformation, l'innovation et le management d’équipe.Notre client est un groupe de conseil en transformation, management et stratégie français indépendant. Il accompagne ses clients sur leurs grands projets de...

  • Cell Line Development Expert

    il y a 4 semaines


    Soisy-sur-Seine, Île-de-France Kyron Temps plein

    Description PosteWe are seeking a highly skilled and entrepreneurial-minded CHO cell line development expert to join our team at Kyron. As a key member of our R&D team, you will be responsible for the execution of feasibility studies for industry partners, testing different genetic integration strategies in CHO cells, and optimizing growth conditions.Roles...


  • Gif-sur-Yvette, Île-de-France Servier Temps plein

    We are a global leader in cardiology and a focused player in oncology, committed to therapeutic progress for the benefit of patients.Our team dedicated to drug biotransformation is seeking a motivated and experienced scientist to work on exciting projects, ranging from small molecules to new therapeutic modalities such as ASOs and...


  • Gif-sur-Yvette, Île-de-France Servier Temps plein

    We are a global leader in cardiology and a focused player in oncology, dedicated to therapeutic progress for the benefit of patients.Our team is seeking a motivated and experienced scientist to join our efforts in drug biotransformation and biodistribution.Key Responsibilities:Design and conduct drug metabolism studies for the discovery and development of...


  • Gif-sur-Yvette, France Servier Temps plein

    . We are a human-scale, international, and independent pharmaceutical group governed by a Foundation. Our unique model is a source of pride for us, but more importantly, it allows us to fully serve our mission: "committed to therapeutic progress for the benefit of patients." Today, as a global leader in cardiology, we have chosen to become a focused and...

  • Consultant Senior

    il y a 3 semaines


    Neuilly-sur-Seine, France SQUARE Temps plein

    Poste : VOTRE FUTURDans le cadre du renforcement de notre Domaine d'Excellence (DomEx) " Data ", vous interviendrez en tant que consultant sur des missions liées à la gestion des données et à l'optimisation des architectures Big Data pour nos clients. Vous serez responsable des phases de traitement, transformation et...

  • Consultant Senior

    il y a 3 semaines


    Neuilly-sur-Seine, France SQUARE Temps plein

    Poste : VOTRE FUTUR Dans le cadre du renforcement de notre Domaine d'Excellence (DomEx) " Data ", vous interviendrez en tant que consultant sur des missions liées à la gestion des données et à l'optimisation des architectures Big Data pour nos clients. Vous serez responsable des phases de traitement, transformation et intégration des données,...