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Senior Scientist, LC-MS Analytical Development

il y a 4 semaines

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DNA Script

DNA Script is a leading company in the production of nucleic acids for genomic, synthetic biology and biopharmaceutical applications.

Our clean, efficient Enzymatic DNA Synthesis (EDS) technology, implemented on a benchtop instrument (the SYNTAX), accelerates innovation in life science and biotechnology through the decentralization of rapid, on demand and high quality DNA synthesis.

Our approach builds upon nature's billions of years of evolution in enzymatically synthesizing DNA, setting new standards for assembling nucleic acids to accelerate scientific discovery and DNA/RNA production in disciplines with profound impacts upon humanity.

DNA Script has a broad stable of high quality investors and is capitalized to continue its progress to full commercialization of the technology and products. We are building an organization across our two sites, in Paris and San Francisco, with the talent, skills and attitude to achieve our mission: to unlock the power of "DNA-write".

This is an opportunity for a dynamic individual to join an international and highly skilled team, and to make significant contributions to commercializing a technology with far-reaching potential across the biological sciences and beyond.

We are looking for a Senior Analytical Development Scientist in the Analytics Team. His/her main mission will be to :
  • Lead analytical development projects using UPLC/UV, UPLC/MS (SQ, Q-Tof), capillary electrophoresis (Agilent and Waters equipment) ensuring the reliability of the results by progressive validation of the methods,
  • Perform and manage analysis of oligonucleotides samples and the interpretation of the data by collecting results from different analytical techniques in collaboration with R&D teams,
  • Take part to the standardization of lab practices (work instructions, reports, maintenance/ qualification program of the instruments)

The position reports to the Director Reagent Research and will act as a point of reference for Analytic methods in company.

Responsibilities
  • Develop, improve new and existing analytical methods for sample preparation (automation/ liquid handling robot, SPE), characterization and quantification of product/ impurities by UPLC/MS (low or high resolution),
  • Ensure the progressive validation of the methods including the methods transfer in collaboration with the QC team,
  • Take part to the routine analyses program in medium and high throughput to support the R&D projects (oligonucleotides and key reagents as nucleotides and enzymes),
  • Interpret, validate the analytical results using a LIMS,
  • Ensure maintenance and verification of the instruments; enforce their performance by standardizing their use (work Instructions; logbooks; system suitability tests),
  • Write analytical development protocols and reports,
  • Ensure communication with other teams,
  • Contribute to the implementation of new techniques or collaborations,
  • Guarantee bibliography review and state of the art techniques,
  • Participate in the organization of the analytical laboratory

Qualifications and experience

Essential
  • Minimum Master of Science or equivalent Engineering degree: chemical engineer, biochemist or related, preferably in Analytical chemistry, bio-analyzes,
  • At least 5 years of experience in analytical development using LC/MS on biomolecules,
  • Mandatory experience in chromatography (UHPLC), High Resolution Mass Spectrometry and associated software
  • Excellent communication and interpersonal skills,
  • Ability to work independently and within a large multidisciplinary team,
  • Dynamic with a positive attitude willing to commit to a high level,
  • Good written and verbal communication skills in French and in English

Desirable
  • PhD in Analytical Chemistry
  • Experience in the biotech/pharma industry,
  • Start-up mindset.