Contribution of Tumor RHeology in Resistance to
il y a 3 semaines
**Contribution of tumor rheology in resistance to immunotherapies of non-small cell lung cancers**:
- Réf **ABG-127312**
- Sujet de Thèse- 02/12/2024- Contrat doctoral- Dynamics and nanoenvironment of biological membrane- Lieu de travail- Marseille - Provence-Alpes-Côte d'Azur - France- Intitulé du sujet- Contribution of tumor rheology in resistance to immunotherapies of non-small cell lung cancers- Champs scientifiques- Santé, médecine humaine, vétérinaire
- Biologie
- Physique
- Mots clés- Tumeur poumon, microscopie a force atomique, Rhéologie**Description du sujet**:
Lung tumors incidence is steadily increasing especially, non-small cell lung cancer (NSCLC) subtypes. According to the WHO, it is the leading cause of cancer mortality worldwide, accounting for nearly 1.8 million deaths. In France, 53.000 new cases have been recorded in 2022, and with a five-year survival rate of less than 20%, lung cancer is a real public health issue. Recently, the range of treatments has expanded with the development of immunotherapies. Restricted in lung to date to immune-checked point inhibitors (ICI) which target the PD-1/PDL1 pathway by antagonistic antibodies. The marked improvement in the management of this pathology by these therapies has tended to make it a first-line treatment, either in a curative approach or as a neoadjuvant treatment when resection is possible. However, although these approaches have led to substantial progress, the efficiency of these treatments remains heterogeneous, and resistance and relapse are common. Defining the mechanisms responsible for or contributing to such resistance is a major challenge in oncology. Mechanical contribution has not been investigated yet whereas lungs are intrinsically a tissue in which mechanical stress is of obvious importance related to respiration motions. Determining whether the mechanical properties of tumor cells and their microenvironment play a role in NSCLC resistance to ICI immunotherapies and potential relapse is the core and the main objective of this thesis project. To this end, we propose to exploit and analyze patient samples referenced, available, stored and provided by the Biological Resources Center (CRB) of the AP-HM. These samples from patients treated with ICI in a neoadjuvant context prior to resection will be used to generate rheology maps (stiffness and viscoelasticity) by atomic force microscopy (AFM) and correlate them with immunolabeling characterizing the immune infiltrate. The superposition of these different maps will then be performed and analyzed to correlate mechanical properties with the nature, abundance and location of the immune infiltrate. The analyses will be performed by a bioinformatician in collaboration with a theoretical modeler. To maximize the translational aspect of the project and to be closest to the health care needs, we will focus on NSCLC subtypes for which no efficient treatments are available, and ICI are prescribed by lack of alternative options even if they are considered like inefficient. Among these problematic subtypes those harboring oncogenic expression of KRAS associated with the inactivation of STK11 or KEAP1 genes have been chosen. At completion this translational and interdisciplinary thesis would determine the tumor mechanical contribution to ICI resistance, define a model of immune infiltrate according to tumor rheologic features and better characterize two NSCLC subtypes without therapeutical answer. Coordinated by Dr. Michael Sebbagh biologist at DyNaMo research unite UMR1325, it will also involve AP-HM lung oncologists. The study will be carried out within the Inserm Interdisciplinary unit DyNaMo which has all the equipment and expertise required for the project to run smoothly.
**Prise de fonction**:
- 03/03/2025**Nature du financement**:
- Contrat doctoral**Précisions sur le financement**:
- La demande prête à être soumise. Résultat en Janvier Février **Présentation établissement et labo d'accueil**:
- Dynamics and nanoenvironment of biological membraneDyNaMo est une unité de recherche INSERM sur le campus de l'Université Aix-Marseille de Luminy.
Cette unité interdiscplinaire regroupe Physicient, Biologiest, Neurologiste et Theoricient afin de mieux comprendre le vivant par des approches multiples et complémentaires.
**Site web**:
**Intitulé du doctorat**:
- Doctoral de Biologie / Biophysique**Pays d'obtention du doctorat**:
- France**Etablissement délivrant le doctorat**:
- Aix-Marseille Université**Ecole doctorale**:
- Sciences de la vie et de la santé**Thèse en cotutelle **:Oui
- **Pays d'obtention du doctorat en cotutelle**:
- France**Etablissement délivrant le doctorat en cotutelle**:
- Aix-Marseille universitéLe projet est centré sur des mesures et microscopie atomique et photonique suivie d'une analyse d'image correlative. Une expertise dans ces disciplines et en traitement et analyse d'image est un plus.
Il / elle devra avoir un bon niveau
-
Restaurant Manager to Work in Ireland
Il y a 6 mois
Marseille, France The iNUA Collection Temps plein**Who We Are** The iNUA Collection has a diverse range portfolio that allows us to offer opportunities in many different career areas. Whether you are looking for a 5-star experience or an urban style city experience, you will find it here at The INUA Collection! A world of opportunities awaits you at The iNUA collection. **Primary Objective of Restaurant...
-
Marseille, France Inria Temps pleinA propos du centre ou de la direction fonctionnelleThe Inria center at Université Côte d'Azur includes 42 research teams and 9 support services. The center's staff (about 500 people) is made up of scientists of different nationalities, engineers, technicians and administrative staff. The teams are mainly located on the university campuses of Sophia...
-
Assistant Front Office Manager to Work in Ireland
Il y a 7 mois
Marseille, France iNUA Collection Careers Temps pleinWe are now looking for an **Assistant Front Office Manager** to lead the team at one of our hotels, **The iNUA Collection**. As the Assistant Front Office Manager, you will play a pivotal role in ensuring the smooth operation of our hotel's front desk and guest services. Working closely with the Front Office Manager, you will supervise and lead a team of...
-
Spa Manager to Work in Ireland
Il y a 6 mois
Marseille, France iNUA Collection Careers Temps plein**All our hotels are in Ireland. This position is advertised in this location but all our hotels - **iNUA Hotels** - are located in Ireland.** We are currently looking for a dedicated and detail-oriented individual to join our team as a **Spa Manager **for one of our hotels. **In this role, you will**: - Oversee all aspects of spa operations, ensuring...
-
Spa Therapist to Work in Ireland
Il y a 7 mois
Marseille, France iNUA Collection Careers Temps plein**Do you thrive in a world of relaxation and rejuvenation? Are you passionate about creating unforgettable spa experiences?** If so, we invite you to join our team and be part of The iNUA Collection family! As a **Spa Therapist **at **The iNUA Collection**,** **you will play a pivotal role in delivering exceptional service to our valued guests. You will...
-
Marseille, France Inria Temps plein_Le descriptif de l’offre ci-dessous est en Anglais_ **Niveau de diplôme exigé**: Bac + 4 ou équivalent **Fonction**: Stagiaire de l'ingénierie **A propos du centre ou de la direction fonctionnelle**: The Inria center at Université Côte d'Azur includes 42 research teams and 9 support services. The center’s staff (about 500 people) is made up of...
-
Spa Therapist to Work in Ireland
Il y a 6 mois
Marseille, France iNUA Collection Careers Temps plein**Do you thrive in a world of relaxation and rejuvenation? Are you passionate about creating unforgettable spa experiences?** If so, we invite you to join our team and be part of The iNUA Hotel Collection family! As a **Spa Therapist **at **The iNUA Hotel Collection**,** **you will play a pivotal role in delivering exceptional service to our valued guests....
-
Function and Inhibition of Therapeutic Targets in
Il y a 3 mois
Marseille, France Centre de Recherche en cancérologie de Marseille (CRCM) Temps plein**Function and inhibition of therapeutic targets in leukemia**: - Réf **ABG-125962** - Sujet de Thèse- 24/09/2024- Autre financement public- Centre de Recherche en cancérologie de Marseille (CRCM)- Lieu de travail- Marseille - Provence-Alpes-Côte d'Azur - France- Intitulé du sujet- Function and inhibition of therapeutic targets in leukemia- Champs...
-
Marseille, France INRIA Temps pleinContexte et atouts du poste This PhD position will take place in the environment of the Inria-Inserm team COMPO (COMputational Pharmacology in Oncology), located in the La Timone health campus. The team is composed of mathematicians, data scientists, pharmacists and clinicians and is a unique multidisciplinary environment focused on developing novel...
-
Research assistant position F/H
Il y a 8 mois
Marseille, France Aix-Marseille Université Temps pleinMission Context This position is offered in the context of the AMIDEX chaire d’excellence . The project aims to characterize novel cancer surface markers and corresponding antibodies for the fluorescent and radio-imaging of tumors in vivo.EnvironmentThe successful applicant will work at the Cancer Research Center of Marseille () in the Glyntera team, led...
-
Marseille, France KEDGE Business School Temps pleinAssistant / Associate /Full Professor in Sociocultural Approaches to Consumption and Market Studies(Campus of Marseille or Bordeaux)Marketing DepartmentKEDGE Business School is a business school with 4 campuses in France (Paris, Bordeaux, Marseille, and Toulon), 3 abroad with 2 in China (Shanghai and Suzhou), 1 in Africa (Dakar) and 4 associated campuses...
-
Chief of Staff
Il y a 2 mois
Marseille, France CMACGM Temps pleinLed by Rodolphe Saadé, the CMA CGM Group, a global leader in shipping and logistics, serves more than 420 ports around the world on five continents. With its subsidiary CEVA Logistics, a world leader in logistics, and its air freight division CMA CGM AIR CARGO, the CMA CGM Group is continually innovating to offer its customers a complete and increasingly...
-
Head of Enterprise Architecture
Il y a 6 mois
Marseille, France Ceva Logistics Temps pleinCEVA Logistics provides global supply chain solutions to connect people, products and providers all around the world. Present in 170 countries and with more than 110,000 employees spread over 1,300 sites, we are well on our way to achieving our vision: to be a Top 5 global 3PL. We believe that our employees are the key to our success. We want to engage and...
-
Head of Enterprise Architecture
Il y a 6 mois
Marseille, France Ceva Logistics Temps pleinCEVA Logistics provides global supply chain solutions to connect people, products and providers all around the world. Present in 170 countries and with more than 110,000 employees spread over 1,300 sites, we are well on our way to achieving our vision: to be a Top 5 global 3PL._ - We believe that our employees are the key to our success. We want to engage...
-
Research Director for In Vivo and In Vitro Operations
il y a 2 semaines
Marseille, Provence-Alpes-Côte d'Azur, France Pivot Search Temps pleinKey Job ResponsibilitiesThe successful candidate will be responsible for leading a team of 10 researchers, providing mentorship, guidance, and performance evaluations. They will oversee the design, execution, and analysis of both in vivo and in vitro studies related to CNS and PNS research.Project ManagementDevelop and implement project plans, ensuring...
-
Head of Thematic Initiatives
Il y a 6 mois
Marseille, France World Water Council - Conseil Mondial de l'Eau Temps plein**JOB OFFER - HEAD OF THEMATIC INITIATIVES** **Working time: 100%** **Venue: Headquarters of the World Water Council, Marseille, France Working languages: English and French** **Proven international experience.** Under the general supervision of the President, the Head of thematic initiatives will undertake the following tasks: **1.** **Thematic...
-
Head of Marketing
Il y a 2 mois
Marseille, France CMACGM Temps pleinLed by Rodolphe Saadé, the CMA CGM Group, a global leader in shipping and logistics, serves more than 420 ports around the world on five continents. With its subsidiary CEVA Logistics, a world leader in logistics, and its air freight division CMA CGM AIR CARGO, the CMA CGM Group is continually innovating to offer its customers a complete and increasingly...
-
Synthèse Organique Pour Une Application en
il y a 4 semaines
Marseille, France Université d'Aix-Marseille Temps pleinRéf **ABG-127242** - Sujet de Thèse- 27/11/2024- Financement public/privé- Université d'Aix-Marseille- Lieu de travail- Marseille - Provence-Alpes-Côte d'Azur - France- Intitulé du sujet- - Champs scientifiques- Chimie - Biologie - Mots clés- Chimie organique, synthèse, biologie, radicaux, cancer, paludisme**Description du sujet**: The originality of...
-
Head of Pricing Project Cargo
Il y a 6 mois
Marseille, France CMACGM Temps pleinLed by Rodolphe Saadé, the CMA CGM Group, a global leader in shipping and logistics, serves more than 420 ports around the world on five continents. With its subsidiary CEVA Logistics, a world leader in logistics, and its air freight division CMA CGM AIR CARGO, the CMA CGM Group is continually innovating to offer its customers a complete and increasingly...
-
Head of Architecture
Il y a 3 mois
Marseille, France Ceva Logistics Temps pleinCEVA Logistics provides global supply chain solutions to connect people, products and providers all around the world. Present in 170 countries and with more than 110,000 employees spread over 1,300 sites, we are well on our way to achieving our vision: to be a Top 5 global 3PL._ - We believe that our employees are the key to our success. We want to engage...
