Chronic Inflammatory Diseases Endotyping Researcher

Le descriptif de l’offre ci-dessous est en Anglais_

**Type de contrat **:CDD

**Niveau de diplôme exigé **:Thèse ou équivalent

**Fonction **:Chercheur contractuel

**Niveau d'expérience souhaité **:De 3 à 5 ans

**A propos du centre ou de la direction fonctionnelle**:
The Inria University of Lille centre, created in 2008, employs 360 people including 305 scientists in 15 research teams. Recognised for its strong involvement in the socio-economic development of the Hauts-De-France region, the Inria University of Lille centre pursues a close relationship with large companies and SMEs. By promoting synergies between researchers and industrialists, Inria participates in the transfer of skills and expertise in digital technologies and provides access to the best European and international research for the benefit of innovation and companies, particularly in the region.

For more than 10 years, the Inria University of Lille centre has been located at the heart of Lille's university and scientific ecosystem, as well as at the heart of Frenchtech, with a technology showroom based on Avenue de Bretagne in Lille, on the EuraTechnologies site of economic excellence dedicated to information and communication technologies (ICT).

**Contexte et atouts du poste**:
The position will take place in a pluridisciplinary team composed of mathematicians, data scientists, clinicians; a unique multidisciplinary environment focused on developing novel computational tools for **chronic inflammatory diseases (CID) to better understand them and the applied treatments**. The person to be recruited will benefit from a secured access to large local hospital repository composed of multi-omics data, to additional large European databases and to the required computing resources. The proximity with top level medical researchers in the domain will allow for a fine exploration of this mass of clinical data.
- This job offers unique possibilities in a rich collaborative context including a world-wide recognised research team in precision medicine supported by Inria, Inserm and Lille university hospital centre.
- It also allows a unique access to large bank of medical data.
- The person to be recruited with work in collaboration with Pr. Vincent Sobanski, from CHU and INSERM.

**Mission confiée**:
The goal of this position is to develop innovative methods to characterize endotypes of chronic inflammatory diseases (CID) based on the integrative analysis of patients combining clinical and follow-up data (highly heterogeneous information) and multi-omics profiles (high-dimensional information). This will allow to improve the CID nosology.

**Principales activités**:
**Main activities**:

- Review of the literature
- Benchmark of existing methods
- Development of novel supervised and non supervised clustering algorithms for multiomic data
- Interactions with the biological and clinical partners
- Supervision of data scientists (research engineers, phd students and postdoctoral fellows)
- Test and validation

**Additional activities**:

- Continuous integration / continuous deployment of the code
- Data visualization
- Statistical reporting to the partners

**Compétences**:
Technical skills and level required:

- Strong background in statistics and machine learning
- Hands-on experience with real-world medical data analysis
- Experience in computer vision is a plus
- Knowledge of biology and/or medicine is a plus
- Ability to work both independently and as a team, good relational skills
- Excellent programming skills in a scripting language (R and/or Python)

Additional:

- English speaking
- Academic writing skills
- Oral presentation skills

**Avantages**:

- Subsidized meals
- Partial reimbursement of public transport costs
- Leave: 7 weeks of annual leave + 10 extra days off due to RTT (statutory reduction in working hours) + possibility of exceptional leave (sick children, moving home, etc.)
- Possibility of teleworking and flexible organization of working hours
- Professional equipment available (videoconferencing, loan of computer equipment, etc.)
- Social, cultural and sports events and activities
- Access to vocational training
- Social security coverage

**Rémunération**:
According to the profile

**Informations générales**:

- **Ville**: Villeneuve d'Ascq
- **Centre Inria**: Centre Inria de l'Université de Lille
- **Date de prise de fonction souhaitée**: 2024-12-01
- **Durée de contrat**: 2 ans
- **Date limite pour postuler**: 2024-10-31

**Consignes pour postuler**:
**Sécurité défense**:
Ce poste est susceptible d’être affecté dans une zone à régime restrictif (ZRR), telle que définie dans le décret n°2011-1425 relatif à la protection du potentiel scientifique et technique de la nation (PPST). L’autorisation d’accès à une zone est délivrée par le chef d’établissement, après avis ministériel favorable, tel que défini dans l’arrêté du 03 juillet 2012, relatif à la PPST. Un avis ministéri