Organic Chemist

Offer type: organic chemist, assistant ingénieur

Financing: Fondation Philippe Maupas

Salary range: 1750 € monthly net income

Recruiting organization: UMR1100 CEPR INSERM - Université de Tours, Team 2 “Proteolytic enzymes and their pharmacological targeting in lung diseases”, group “Immunoconjugates” (C. Denevault, N. Joubert)

Workplace: TOURS (37000) - FRANCE

Skill area: bioconjugation, therapeutic chemistry, organic chemistry, heterocyclic chemistry

**Site web**:
**Poste et missions**:
**PROJECT**:
This project is divided in several tasks. **In our team**: (1) synthesis of drug-linker and bioconjugation onto mAbs to produce new immunoconjugates; (2) analysis and characterization of prepared immunoconjugates: physico-chemical properties, (3) _in vitro_ evaluation of proteolytic cleavage. **In collaboration**: (4) _in vitro_ characterization of antigen binding affinity; (4) _in vitro_ evaluation of immunoconjugates cytotoxicity (collaboration with CEPR team 1, Tours); (5) _in vivo_ studies on different murine models (collaboration with CEPR team 1, Tours). This project is attached to high-priority programmes dedicated to therapeutic biodrugs and antibodies (PEPR ANR FRANCE2030, ARD CVL Biomédicaments, APR IR, Labex MabImprove, Cancéropôle Grand Ouest).

**Mobilité géographique**:

- Nationale**Télétravail**:

- Impossible
- organic synthesis in laboratory_

**Prise de fonction**:

- 01/01/2025**Profil**:
**Objectifs**:
**For this new project, the recruited ORGANIC CHEMIST assistant engineer** **will work in synergy with a PhD student **to synthesize new linkers for their bioconjugation onto different mAbs. Our collaboration (Team 1 CEPR, Tours) will then characterize and evaluate the resulted ADCs_ in vitro_ and _in vivo_ in mouse models.