Neurotoxic Effects of Chronic Perinatal

Il y a 2 mois

Marseille, France Institut de neurobiologie de la méditerranée - Inmed UMR1249 Temps plein

**Neurotoxic effects of chronic perinatal insecticides exposure on brain development**:

- Réf
- **ABG-116049**
- Sujet de Thèse- 26/07/2023- Contrat doctoral- Institut de neurobiologie de la méditerranée - Inmed UMR1249- Lieu de travail- Marseille - Provence-Alpes-Côte d'Azur - France- Intitulé du sujet- Neurotoxic effects of chronic perinatal insecticides exposure on brain development- Champs scientifiques- Psychologie, neurosciences
- Santé, médecine humaine, vétérinaire
- Mots clés- Insecticides, Autism, Brain development, neural network**Description du sujet**:

- Exposure to agricultural insecticides during the perinatal period is associated with an increased risk of autism spectrum disorders (ASD). Environmental agencies also warn of their intensive use in indoor air, particularly by pregnant women.- The project aims at deciphering whether prenatal exposure to inhaled insecticides disrupts the developmental sequence of nervous networks, leading to lasting alterations in social and cognitive behavior.- We are a consortium of neurobiologists and atmospheric chemists modeling environmental exposure to human insectides in mice. We will confront strict prenatal exposures to prolonged postnatal exposures in combination with indoor versus outdoor concentration on the onset of neurodevelopmental disorders.**The project of the PhD position is to evaluate the Offspring at behavioral, electrophysiological and molecular levels.**

**Prise de fonction**:

- 01/11/2023**Nature du financement**:

- Contrat doctoral**Précisions sur le financement**:

- ANR fundings (Brainicide)**Présentation établissement et labo d'accueil**:

- Institut de neurobiologie de la méditerranée - Inmed UMR1249-
**Site web**:
**Intitulé du doctorat**:

- Doctorat Sciences de la Vie, Neurosciences**Pays d'obtention du doctorat**:

- France**Etablissement délivrant le doctorat**:

- Aix-Marseille Université**Ecole doctorale**:

- Sciences de la vie et de la santé**Required skills**:

- Expertise in Electrophysiology including patch-clamp recording.- Skills in animal experimentation or mice Behavior- Comprehensive knowledge in single-cell RNA seq**Required profile**:

- Motivation, rigor, organization, good communication- Fluent in written and spoken English**Master degree in Neuroscience or equivalent**- 30/11/2023

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