Computational Engineer

**Apmonia Therapeutics** is a biotechnology company developing a first-in-class pipeline of next-generation peptide-based therapies targeting extracellular matrix components. Its most advanced technology is an antagonist being selective for TSP-1:CD47 interaction, namely TAX2 peptide, which exhibits anticancer activities in several indications and is about to enter clinical development.

**Site web**:
**Poste et missions**:
**Responsibilities**:

- Design and implement new experimental protocols
- Provide technical leadership in molecular modeling
- Conduct experiments, analyze data and interpret results, draw conclusions, and propose new integrated experimental plan matching project needs
- Prepare study protocols, WIs, SOPs, and reports in line with regulatory requirements
- Keep clear and accurate records of experiments in laboratory notebooks. Ensure traceability of data and samples
- Maintain knowledge of literature and bring independent judgment

**Mobilité géographique**:

- Nationale**Télétravail**:

- Occasionnel**Prise de fonction**:

- 17/04/2023**Profil**:
**Qualifications and Desirable knowledge, skills and abilities**
- Hold a PhD in Molecular Modeling
- Extensive knowledge/skills in Ligand:Protein and Protein:Protein docking calculations

as well as in running and analyzing molecular dynamics simulations performed on

soluble and/or membrane proteins
- Good skills in writing scripts and/or programming under the Linux environment is

required
- Excellent oral communication skills for synthetically and concisely presenting

generated results
- Excellent oral and written communication skills in English
- Highly motivated, proactive with excellent team spirit
- Autonomous, flexible, and responsive
- Appreciates lab work in a dynamic and evolving environment
- Strong organizational, interpersonal, and time-management skills

**_Ideally, you also have experience with some of the following_**

Good knowledge of the Coarse-Grained MARTINI Force-Field

Project Management

Biology background

**Objectifs**:
Engineer will be in charge of molecular modelling activities involving prediction of the binding of peptides and derivates to a soluble protein target, as well as to predict the interaction of this protein with its membrane receptor.