Translational Research Scientist Skin Immunology

Il y a 3 mois

Paris, France Eligo Bioscience Temps plein

**// ABOUT ELIGO**

Eligo Bioscience's mission is to develop precision medicines to address serious unmet medical needs in the field of inflammatory diseases, infectious diseases and oncology.

Backed by top-tier investors from Silicon Valley and Europe, Eligo is an industry-leading biotechnology company, co-founded by scientists and professors from MIT and the Rockefeller University - now operating in Paris, France. We are progressing next-generation precision medicines through in vivo gene editing of the microbiome.

Our pioneering work in the field of synthetic biology has enabled Eligo to be elected as one of the 30 Most Innovative Companies by the World Economic Forum, to receive multiple prestigious international awards. We have also been featured in international media and scientific journals such as Nature Biotechnology, Science, The Economist, The BBC and The New York Times.

**// YOUR MISSION**

At Eligo Bioscience, we are passionate about developing new drugs to address microbiome-associated unmet medical needs As part of the Host-Microbes interaction team you will both contribute to the generation of pivotal preclinical data to support the development of Eligo's programs towards the clinic, and to more exploratory target discovery work to guide the inclusion of new programs to the Eligo portfolio.

**// **

The Host-Microbes interaction scientist is part of a team of 4 translational scientists and a principal associate scientist with strong experience in the set up and execution _in vitro, ex vivo _and _in vivo _models across various fields (immunology, microbiology, molecular biology, pharmacology) to support preclinical development of Eligo's programs either internally or in collaboration with external partners. They report to the Senior Director of Host-Microbes interactions.

**// RESPONSIBILITIES**
- Design, execute, and oversee hands-on experiments across _in vivo_ (rodents), _ex vivo _(human or rodent primary cells and tissues), and _in vitro_ (cell lines, bacterial cultures) models, employing diverse cellular biology, immunology, microbiology, and molecular biology techniques.
- Analyze, interpret, and effectively communicate experimental findings at various meetings involving multidisciplinary teams and/or collaborators.
- Independently plan experimental paths forward, proactively develop and/or optimize methods, and incorporate new technology/techniques into practice.
- Prepare comprehensive reports and presentation materials as necessary, and maintain meticulous experimental documentation in electronic lab notebooks in accordance with Eligo's working practice.
- Contribute to scientific review meetings and assist in drafting relevant sections of regulatory documents as needed.
- Foster a collaborative and supportive environment, aiding in the development and well-being of fellow team members while also participating in general lab support operations.
- Stay aware of recent advancements in the field through literature review and dissemination of data via presentations at scientific conferences when appropriate.

**// APPLICANT PROFILE**

**Technical skills**
- PhD in Immunology, Microbiology, or related fields with a track record of publications
- Deep knowledge and hands-on experience in the field of skin immunology, skin microbiology or skin biology
- Postdoctoral training or previous drug discovery or development experience in a biopharmaceutical setting is advantageous.
- Hands-on experience in models and assays recapitulating skin and hair follicle structure is advantageous.
- Outstanding expertise in 2D and 3D cell culture techniques
- Outstanding expertise in cell isolation from human and rodent primary tissues and blood. Experience in isolation of cells from primary skin tissue is advantageous.
- Ability to design and run experiments, interpret data, troubleshoot, suggest next steps and identify alternative approaches.
- Ability to deliver high-quality, consistent results in a timely fashion.
- Experience in immunological and molecular biology techniques including but not limited to flow cytometry, nucleic acid extraction, qPCR/ddPCR, ELISA, Western Blotting. Proficiency in utilizing functional genomic editing tools (CRISPR-Cas, si/hRNA) is advantageous.

**Other skills**
- Self-motivated, creative and critical thinker with a ‘can-do' attitude eager to contribute to the development of novel therapeutics
- Independent, proactive, and with a strong sense of accountability.
- Flexible, adaptable, open to new ideas and able to function under pressure.
- Meticulous, rigorous, result-oriented and committed to scientific integrity and ethics
- Outstanding organization skills, time management, and able to prioritize tasks across multiple projects in a fast-paced environment.
- Effective team player with excellent interpersonal skills
- Experience in managing relationships with external collaborators is advantageous

Join us as we build the future of precision microbiome medicines

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