![Inria](https://media.trabajo.org/img/noimg.jpg)
Analyzing Cell State Transition of Tumor Cells From Tolerant to Sensitive to Cancer Therapeutics, Using Single-cell Data
il y a 4 jours
_Le descriptif de l’offre ci-dessous est en Anglais_
**Type de contrat**: CDD
**Niveau de diplôme exigé**: Bac + 5 ou équivalent
**Fonction**: Ingénieur scientifique contractuel
**Niveau d'expérience souhaité**: Jeune diplômé
**A propos du centre ou de la direction fonctionnelle**:
The Inria center at Université Côte d'Azur includes 42 research teams and 9 support services. The center’s staff (about 500 people) is made up of scientists of different nationalities, engineers, technicians and administrative staff. The teams are mainly located on the university campuses of Sophia Antipolis and Nice as well as Montpellier, in close collaboration with research and higher education laboratories and establishments (Université Côte d'Azur, CNRS, INRAE, INSERM...), but also with the regional economic players.
With a presence in the fields of computational neuroscience and biology, data science and modeling, software engineering and certification, as well as collaborative robotics, the Inria Centre at Université Côte d'Azur is a major player in terms of scientific excellence through its results and collaborations at both European and international levels.
**Contexte et atouts du poste**:
The molecular mechanisms involved in tumor cell tolerance to immune cell killing or to cancer therapeutics contribute to the partial treatment efficacy and therefore represent potential targets for combination treatments. Identifying these molecular mechanisms is an essential task in the rational design of efficacious drug combinations.
It has been shown that drug-tolerant cells can emerge from transient differences in cellular contexts and we have established an approach to profile single-cell tolerance of non-genetic origins [1]. At the modeling level, we developed an approach to detect cellular mechanisms responsible for the amplification of transient and small differences, that ultimately lead to significant differences in single-cell signatures and dynamic response of sensitive or tolerant phenotypes [2].
The objective of this short project is to study and understand the cell state transition of tumor cells between sensitive and tolerant modes, by the analysis of RNAseq data as well as a set of kinetic parameters associated to a mathematical model. This work is funded by a collaborative project between M. Chaves at MACBES team at Inria Center of Université Côte d'Azur and J. Roux single-cell biology lab at the Institut de Pharmacologie Moleculaire et Cellulaire, CNRS.
**Mission confiée**:
The first task is this project to use diffusion maps to analyze RNAseq data (see, for example, the R-package Destiny [3]). This will give us a landscape of genetic signatures covering both sensitive and tolerant cells, and we will investigate the adaptation of cells to a drug or an immune effector by detecting "pseudo-trajectories" between the two phenotypes.
The second task is to similarly analyse a set of kinetic parameters obtained from the mathematical models previously developed in our team. These models provide a set of parameters for each cell, which serve as a first distinction between sensitive and tolerant cell states. Here, we will look for features that separate the two groups in the parameter space.
Finally, we will systematize a method for comparison of the RNAseq data and kinetic parameter analysis and establish a link between genomic data and kinetic parameters.
References:
[1] Mickael Meyer, Agnès Paquet, Marie-Jeanne Arguel, Ludovic Peyre, Luis C. Gomes-Pereira, Kevin Lebrigand, Baharia Mograbi, Patrick Brest, Rainer Waldmann, Pascal Barbry, Paul Hofman, Jérémie Roux, Profiling the Non-genetic Origins of Cancer Drug Resistance with a Single-Cell Functional Genomics Approach Using Predictive Cell Dynamics, Cell Systems, 11(4), 367-374.e5 (2020).
[2] Chaves, M., Gomes-Pereira, L.C., and Roux, J. Two-level modeling approach to identify the regulatory dynamics capturing drug response heterogeneity in single-cells. Sci Rep 11, 20809 (2021).
[3] Angerer P, Haghverdi L, Büttner M, Theis FJ, Marr C & Buettner F (2016) Destiny: Diffusion maps for large-scale single-cell data in R. Bioinforma Oxf Engl 32: 1241-1243
**Principales activités**:
2. Numerical simulations and analysis of the results.
3. Writing a report on the project.
**Compétences**:
**Avantages**:
- Subsidized meals
- Partial reimbursement of public transport costs
- Leave: 7 weeks of annual leave + 10 extra days off due to RTT (statutory reduction in working hours) + possibility of exceptional leave (sick children, moving home, etc.)
- Possibility of teleworking (after 6 months of employment) and flexible organization of working hours
- Professional equipment available (videoconferencing, loan of computer equipment, etc.)
- Social, cultural and sports events and activities
- Access to vocational training
**Rémunération**:
From 2692 € gross monthly (according to degree and experience).
**Informations générales**:
- **Thème/Domaine**: Modélisation et comm
-
Post-doctoral Research Visit F/m Topological
il y a 2 semaines
Sophia Antipolis, France Inria Temps pleinLe descriptif de l’offre ci-dessous est en Anglais_ **Type de contrat **:CDD **Niveau de diplôme exigé **:Thèse ou équivalent **Fonction **:Post-Doctorant **A propos du centre ou de la direction fonctionnelle**: The Inria center at Université Côte d'Azur includes 42 research teams and 9 support services. The center’s staff (about 500 people) is...
-
Research Engineer for Ai Project in Prostate Cancer
Il y a 3 mois
Sophia Antipolis, France Inria Temps pleinLe descriptif de l’offre ci-dessous est en Anglais_ **Niveau de diplôme exigé **:Bac + 5 ou équivalent **Fonction **:Ingénieur scientifique contractuel **Niveau d'expérience souhaité **:Jeune diplômé **A propos du centre ou de la direction fonctionnelle**: The Inria center at Université Côte d'Azur includes 42 research teams and 9 support...
-
Rapid Solid-state Phase Transformations By
Il y a 2 mois
Sophia Antipolis, France Centre de Mise en Forme des Matériaux (CEMEF) Temps plein**Rapid solid-state phase transformations by combining controlled pulse heating experiments and Calphad consistent modeling considering the non-equilibrium**: - Réf **ABG-126302** - Sujet de Thèse- 15/10/2024- Contrat doctoral- Centre de Mise en Forme des Matériaux (CEMEF)- Lieu de travail- Sophia Antipolis - Provence-Alpes-Côte d'Azur - France-...
-
Expert SoC IP Verification Specialist
il y a 4 semaines
Sophia Antipolis, Provence-Alpes-Côte d'Azur, France arm limited Temps pleinUnlock the Potential of Advanced SoC DesignAbout the Role:We are seeking an experienced SOC IP Verification Specialist to join our team at Arm Limited. As a key member of our design community, you will play a crucial role in verifying Third-Party IPs (TPIP) before embedding them in our System-on-Chip (SoC) designs.Your Key Responsibilities:Verify TPIP...
-
Phd Position F/m Compiling Dynamic Languages to
Il y a 6 mois
Sophia Antipolis, France Inria Temps pleinLe descriptif de l’offre ci-dessous est en Anglais_ **Type de contrat **:CDD **Niveau de diplôme exigé **:Bac + 5 ou équivalent **Autre diplôme apprécié **:Master thesis **Fonction **:Doctorant **A propos du centre ou de la direction fonctionnelle**: The Inria centre at Université Côte d'Azur includes 37 research teams and 8 support services....
-
Ai Applied to Ct Scans
Il y a 6 mois
Sophia Antipolis, France Median Technologies Temps pleinSince 2002, Median Technologies has been expanding the boundaries of the identification, interpretation, analysis and reporting of imaging data in the medical world. Our core activity is to develop advanced imaging software solutions and platforms for clinical drug development in oncology, diagnostic support, and cancer patient care. Our software solutions...
-
Graduate Physical Design Engineer
Il y a 6 mois
Sophia Antipolis, France Arm Temps pleinShow more **Job Overview**: We are the Silicon Enablement Implementation team, part of the Arm Physical Design Group. This diverse, engineering-centric group invents, defines and develops innovative physical implementation methods for CPU/GPU class designs using optimized physical IP. We pursue next-generation Arm CPUs and GPUs, inventing new concepts that...
-
Postdoc Toxicologue Recherche Ngra
Il y a 2 mois
Sophia Antipolis, France Bayer Temps plein**PostDoc Toxicologue Recherche NGRA (F/H/X)** **Post Doc Research toxicologist - Complex In Vitro Models for Next Generation Risk Assessment (H/F/X)** **Position Description**: - Design, develop, and implement new _in vitro_ methodologies and complex in vitro assays to predict potential _in vivo_ adverse effects - Establish toxicology and business...
-
Inside Consulting Systems Engineering Intern
il y a 4 semaines
Sophia Antipolis, France Fortinet Temps plein**Internship Description: Inside Consulting Systems Engineering Intern** Fortinet has an exciting internship opportunity for you to join our consulting systems engineering team and contribute to multiple projects. You will play a key role in enhancing the effectiveness of our internal project management product by leveraging Power BI to create dynamic...
-
Project Buyer
Il y a 6 mois
Sophia Antipolis, France TMC Temps pleinSophia AntipolisAs a Project Buyer, you will be accountable for leading and managing purchasing activities: sourcing, planning, production part approval process, tooling investments and Quality Assurance, Risk Management in cross-functional projects, and contributing to project deliveries. **| YOUR CHALLENGES** - Interact with the purchasing community from...
-
Physical Design Intern
Il y a 6 mois
Sophia Antipolis, France Arm Temps plein**Read More** Do you want to help Arm and its partners to build outstanding products? Arm’s Sophia Antipolis design centre is located in one of the most appealing parts of France, at the heart of Europe’s largest and most dynamic technology park. Surrounded by mountains and the Mediterranean Sea, this outstanding design center has delivered leading...
-
Post-doctoral Research Visit F/m Reproducibility of
Il y a 3 mois
Sophia Antipolis, France Inria Temps pleinLe descriptif de l’offre ci-dessous est en Anglais_ **Type de contrat **:CDD **Contrat renouvelable **:Oui **Niveau de diplôme exigé **:Thèse ou équivalent **Fonction **:Post-Doctorant **A propos du centre ou de la direction fonctionnelle**: The Inria Grenoble research center groups together almost 600 people in 23 research teams and 7 research...
-
Phd Position F/m Effective Ai Based
Il y a 3 mois
Sophia Antipolis, France Inria Temps pleinLe descriptif de l’offre ci-dessous est en Anglais_ **Type de contrat **:CDD **Niveau de diplôme exigé **:Bac + 5 ou équivalent **Fonction **:Doctorant **A propos du centre ou de la direction fonctionnelle**: The Inria center at Université Côte d'Azur includes 42 research teams and 9 support services. The center’s staff (about 500 people) is...
-
Phd Position F/m Phd Position Computer Vision
Il y a 6 mois
Sophia Antipolis, France Inria Temps pleinLe descriptif de l’offre ci-dessous est en Anglais_ **Type de contrat **:CDD **Niveau de diplôme exigé **:Bac + 5 ou équivalent **Fonction **:Doctorant **A propos du centre ou de la direction fonctionnelle**: The Inria Université Côte d’Azur center counts 36 research teams as well as 7 support departments. The center's staff (about 500 people...
-
Senior Ip Qualification Engineer
Il y a 6 mois
Sophia Antipolis, France Arm Temps pleinArm teams develop groundbreaking SoC (system on Chip) which embeds the latest Arm Compute Sub-System IP (Intellectual Property) and other various IP coming from external IP companies. We are looking for a creative and dedicated senior engineer to join the IP Qualification team and help verify these Third-Party IPs before they are embedded in SoC. Such TPIP...
-
Fp&a Junior Analyst
Il y a 6 mois
Sophia Antipolis, France Questel Temps plein**Your next adventure awaits here** As part of the FP&A Team within the Finance Department, you will be reporting to either an FP&A Analyst, FP&A Senior Analyst or Manager. Your responsibilities will include: **Reporting** **Business reviews**: The FP&A Department is in charge of issuing and animating a reporting for each of the key product lines of...
-
Fp&a Senior Analyst
il y a 1 mois
Sophia Antipolis, France Questel Temps plein**Your next adventure awaits here** As part of the FP&A Team within the Finance Department, you will be reporting to either the FP&A Director or a FP&A Manager. Your responsibilities will include: **Reporting** Business reviews: The FP&A Department is in charge of issuing and animating a reporting for each of the key product lines of Questel. Those...
-
Fp&a Senior Analyst
Il y a 6 mois
Sophia Antipolis, France Questel Temps plein**Your next adventure awaits here** As part of the FP&A Team within the Finance Department, you will be reporting to either the FP&A Director or a FP&A Manager. Your responsibilities will include: **Reporting** **Business reviews**: The FP&A Department is in charge of issuing and animating a reporting for each of the key product lines of Questel. Those...
-
R&d Engineer
il y a 5 jours
Sophia Antipolis, France Inria Temps plein_Le descriptif de l’offre ci-dessous est en Anglais_ **Type de contrat**: CDD **Contrat renouvelable**: Oui **Niveau de diplôme exigé**: Bac + 5 ou équivalent **Fonction**: Ingénieur scientifique contractuel **A propos du centre ou de la direction fonctionnelle**: The Inria center at Université Côte d'Azur includes 42 research teams and 9...
-
Microbial Community Responses to Host-derived
Il y a 6 mois
Sophia Antipolis, France Inria Temps plein**Type de contrat **:Stage**Niveau de diplôme exigé **:Bac + 4 ou équivalent**Fonction **:Stagiaire de la rechercheA propos du centre ou de la direction fonctionnelle Inria is a national research institute dedicated to digital sciences that promotes scientific excellence and transfer. Inria employs 2,400 collaborators organised in research project teams,...