Modeling Human Homeostatic Capability: Multivariate
il y a 2 semaines
**Modeling human homeostatic capability: multivariate analysis of cardiorespiratory and metabolic exercise tests for health assessment**:
- Réf **ABG-121824**
- Sujet de Thèse- 26/03/2024- Autre financement public- Aix Marseille Université - Laboratoire d'informatique et systèmes- Lieu de travail- Marseille - Provence-Alpes-Côte d'Azur - France- Intitulé du sujet- Modeling human homeostatic capability: multivariate analysis of cardiorespiratory and metabolic exercise tests for health assessment- Champs scientifiques- Numérique
- Santé, médecine humaine, vétérinaire
- Mots clés- IA, Santé, Homéostasie, Tests d'effort**Description du sujet**:
The complete offer is available here:
Context and Positioning
Homeostasis is the process by which living organisms maintain a stable internal balance necessary for their survival and optimal functioning. This process typically involves feedback mechanisms that detect deviations from a target state and activate responses to correct these deviations and return the system to a stable level. The homeostasis capabilities of an individual are used to support medical decision making, such as patients’ peri-operative risk stratification in lung cancer surgery.
The homeostatic abilities of an individual can be assessed through exercise testing, which is the traditional clinical method for evaluating patients' health status and overall systemic dynamics. A series of tests is designed to measure features representative of the individual's homeostatic capabilities, with one significant metric being the maximal oxygen uptake (VO2max). These measurements are obtained through routine functional tests and maximal exercise sessions, aimed at challenging the entire organism to evaluate physiological adaptive responses. When exercise performance or maximal aerobic capacity is limited for a given patient, the medical doctor has to identify the failing physiological function and to provide a coherent system failure mechanics analyzing the monitored data. However, medical doctors still analyze the collected physiological data in a univariate approach as historically developed. Currently, in the research community, the human body is considered as a dynamic physiological complex system. Recently, the framework of network physiology was proposed, giving a central role to homeostasis.
To broaden theoretical knowledge and to fill the gap between current research and medical practice, the Exercise Test Laboratory of Hôpitaux Universitaires de Marseille built its own activity database composed of 2500 exercise tests.
Objectives
This thesis aims at exploiting this dataset in order to provide a global understanding and interpretation framework of the multivariate data generated during maximal exercise testing to improve patients’ homeostasis phenotyping through their homeostatic capabilities.
We aim to develop a medically and statistically consistent approach to identifying and quantifying determinants of overall performance as well as aerobic performance from monitored variables. This would provide physicians with improved analytical tools to achieve a more relevant and precise patient exercise phenotyping.
The thesis project aims to go further and provide physicians with a quantitative decision support indicator. It will be developed by focusing on the dynamic interactions between the recorded variables. Here, we consider in particular adapting the framework of physiological networks to the mesoscopic and macroscopic case of exercise tests. This would provide crucial information to the physician about patients' homeostatic capacities.
Work environment
**Nature du financement**:
- Autre financement public**Précisions sur le financement**:
- Bourse de thèse de l'Institut Laënnec**Présentation établissement et labo d'accueil**:
- Aix Marseille Université - Laboratoire d'informatique et systèmesThe PhD is part of the collaboration between two laboratories in Marseille : le Laboratoire d’Informatique et des Systèmes (LIS), et le Centre de Recherche en Cardiovasculaire et Nutrition (C2VN)
C2VN is a multidisciplinary lab working on cardiovasculary and pulmonary diseases. It has in particular a strong background on physilogical aspects of metabolic pathologies, thanks to its various research platforms.
- System and control theory
- Signal/Image/Graph processing
- Computer science
- Machine learning/Artificial intelligence
Good coding skills are required, preferably in Python- 31/05/2024
-
Human Factors Ergonomics
il y a 4 semaines
Marseille, France AIRBUS HELICOPTERS SAS Temps pleinAirbus Helicopters SAS recrute: A vacancy for a **Human Factors Specialist M/F o**n Cockpit Human Factors & Cockpit Design Department in Engineering, has arisen within Airbus Helicopters in **Marignane **(France). You will join a transnational team of around 48 people (based in France & in Germany) within the ETYAH department in charge of Human Factors and...
-
Human Factors Ergonomics
il y a 1 semaine
Marseille, Provence-Alpes-Côte d'Azur, France AIRBUS HELICOPTERS SAS Temps pleinAirbus Helicopters SAS recrute:A vacancy for a Human Factors Specialist M/F on Cockpit Human Factors & Cockpit Design Department in Engineering, has arisen within Airbus Helicopters in Marignane (France).You will join a transnational team of around 48 people (based in France & in Germany) within the ETYAH department in charge of Human Factors and Cockpit...
-
Human Factors Ergonomics
il y a 4 semaines
Marseille, Provence-Alpes-Côte d'Azur, France Airbus Temps pleinDescription de l'emploi :A vacancy for a Human Factors Specialist M/F on Cockpit Human Factors & Cockpit Design Department in Engineering, has arisen within Airbus Helicopters in Marignane (France) . You will join a transnational team of around 48 people (based in France & in Germany) within the ETYAH department in charge of Human Factors and Cockpit Design...
-
#et6r Human Factors
il y a 3 semaines
Marseille, France Airbus Helicopters SAS Temps pleinEntreprise : Airbus Helicopters SAS - Localisation : Marseille - France - Provence-Alpes-Côte d’Azur - Fonction : #ET6R Human Factors & Cockpit Crew Interface Specialist M/F/f - Type de contrat : Contrat à durée indéterminée (CDI) - Date de publication : 20-01-2023 **Description du poste**: **Description de l'emploi**: A vacancy for a **Human Factors...
-
Human Factors
il y a 3 semaines
Marseille, France Airbus Helicopters SAS Temps pleinEntreprise : Airbus Helicopters SAS - Localisation : Marseille - France - Provence-Alpes-Côte d’Azur - Fonction : Human Factors & Cockpit Crew Interface Specialist M/F - Type de contrat : Contrat à durée indéterminée (CDI) - Date de publication : 20-01-2023 **Description du poste**: **Description de l'emploi**: A vacancy for a **Human Factors &...
-
Human Factors Ergonomics
il y a 4 semaines
Marseille, France airbus Temps pleinJob Description: A vacancy for a Human Factors Specialist M/F on Cockpit Human Factors & Cockpit Design Department in Engineering, has arisen within Airbus Helicopters in Marignane (France). You will join a transnational team of around 48 people (based in France & in Germany) within the ETYAH department in charge of Human Factors and Cockpit Design...
-
Human Factors Ergonomics
il y a 4 semaines
Marseille Area, France Airbus Temps pleinDescription de l'emploi :A vacancy for a Human Factors Specialist M/F on Cockpit Human Factors & Cockpit Design Department in Engineering, has arisen within Airbus Helicopters in Marignane (France) . You will join a transnational team of around 48 people (based in France & in Germany) within the ETYAH department in charge of Human Factors and Cockpit Design...
-
Modelling of The Boundary Plasma During The
il y a 7 jours
Marseille, France CEA - Commissariat à l'Energie Atomique Temps plein**Domaine**: Physique du noyau, atome, molécule **Contrat**: Stage **Intitulé de l'offre**: Modelling of the boundary plasma during the start-up phase of ITER discharges H/F **Sujet de stage**: This internship project aims at adapting and using the SOLEDGE3X-EIRENE boundary plasma simulation code to analyse the start-up phase of ITER discharges when the...
-
Deputy to The Human Resources Division Head Io0407
il y a 1 mois
Marseille, France ITER Temps pleinThe ITER Organization brings together people from all over the world to be part of a thrilling human adventure in southern France—building the ITER Tokamak. We require the best people in every domain. The ITER Organization (IO) is an Equal Opportunity organization committed to diversity and inclusiveness in the workplace. As the IO attracts and retains...
-
Deputy to The Human Resources Division Head Io0407
il y a 4 jours
Marseille, France ITER Temps pleinThe ITER Organization brings together people from all over the world to be part of a thrilling human adventure in southern France—building the ITER Tokamak. We require the best people in every domain. The ITER Organization (IO) is an Equal Opportunity organization committed to diversity and inclusiveness in the workplace. As the IO attracts and retains...
-
Modéliser Chez L'humain Les Cartes Visuelles Et
Il y a 2 mois
Marseille 5e, France Aix Marseille Université Temps plein**Modéliser chez l'humain les cartes visuelles et oculomotrices rétinotopique // Modeling human visual and oculomotor retinotopic maps**: - Réf - **ABG-111926** **ADUM-46193** - Sujet de Thèse- 10/03/2023- Contrat doctoral- Aix Marseille Université- Lieu de travail- Marseille Cedex 05 - France- Intitulé du sujet- Modéliser chez l'humain les cartes...
-
Neuroscience Phd Scholarships in Marseille, France
Il y a 2 mois
Marseille, France NeuroSchool, Aix-Marseille Université Temps plein**Neuroscience PhD scholarships in Marseille, France - Call for applicants**: - Réf - **ABG-111890** - Sujet de Thèse- 09/03/2023- Contrat doctoral- NeuroSchool, Aix-Marseille Université- Lieu de travail- Marseille - Provence-Alpes-Côte d'Azur - France- Intitulé du sujet- Neuroscience PhD scholarships in Marseille, France - Call for applicants- Champs...
-
Sr Net Zero Business Development Manager
il y a 2 semaines
Marseille, France LyondellBasell Industries Temps pleinLocation: Berre l'Etang Cedex, Bouches-du-Rhône, FR, 13131- Req ID: 82762- Facility: Berre Cpb-514- Department: EU Decarbonization- Division: Olefins and Polyolefins and Global ProcuAs part of our activities, we are looking for a **Sr. Net Zero Business Development Manager** **(**F/M)** for US - Europe. **Basic Function**: The Business Development Manager...
-
Post-doctoral Position: Cfd Analysis of Flow
Il y a 2 mois
Marseille, France Institut de radioprotection et de sûreté nucléaire Temps pleinIRSN (Institut de Radioprotection et de Sûreté Nucléaire) is the french public expert in nuclear and radiation risks. Placed under the joint authority of the French Ministries of Defense, Environment, Industry, Research, and Health, it is the technical support organization of the French regulator for nuclear safety. For more information, see the...
-
Post-doctoral Position: Cfd Analysis of Flow
il y a 1 semaine
Marseille, Provence-Alpes-Côte d'Azur, France Institut de radioprotection et de sûreté nucléaire Temps pleinIRSN (Institut de Radioprotection et de Sûreté Nucléaire) is the french public expert in nuclear and radiation risks. Placed under the joint authority of the French Ministries of Defense, Environment, Industry, Research, and Health, it is the technical support organization of the French regulator for nuclear safety. For more information, see the...
-
Business Process Expert
il y a 4 semaines
Marseille, France CMACGM Temps pleinLed by Rodolphe Saadé, the CMA CGM Group, a global leader in shipping and logistics, serves more than 420 ports around the world on five continents. With its subsidiary CEVA Logistics, a world leader in logistics, and its air freight division CMA CGM AIR CARGO, the CMA CGM Group is continually innovating to offer its customers a complete and increasingly...
-
Completion Engineer
il y a 4 semaines
Marseille, France Jacobs Temps pleinChallenging Today. Reinventing Tomorrow. - We're invested in you and your success. Everything we do is more than just a project. It's our challenge as human beings, too. That's why we bring a thoughtful and collaborative approach to every one of our partnerships._ - At Jacobs, we challenge the status quo and redefine how to solve the world's greatest...
-
C++ R&d Engineer F/m
il y a 1 mois
Marseille, France Ansys Temps plein**Requisition #**: 13878 When visionary companies need to know how their world-changing ideas will perform, they close the gap between design and reality with Ansys simulation. For more than 50 years, Ansys software has enabled innovators across industries to push boundaries by using the predictive power of simulation. From sustainable transportation to...
-
Senior R&d Documentation Specialist F/m
il y a 3 semaines
Marseille, France Ansys Temps plein**Requisition #**: 13572 When visionary companies need to know how their world-changing ideas will perform, they close the gap between design and reality with Ansys simulation. For more than 50 years, Ansys software has enabled innovators across industries to push boundaries by using the predictive power of simulation. From sustainable transportation to...
-
C++ R&d Engineer F/m
il y a 4 jours
Marseille, France Ansys Temps plein**Requisition #**: 13878 When visionary companies need to know how their world-changing ideas will perform, they close the gap between design and reality with Ansys simulation. For more than 50 years, Ansys software has enabled innovators across industries to push boundaries by using the predictive power of simulation. From sustainable transportation to...
