Master 2 Internship in Cell Biology and Biophysics
il y a 1 mois
**Master 2 internship in cell biology and biophysics**:
- Réf
- **ABG-116174**
- Stage master 2 / Ingénieur- Durée 6 mois- Salaire net mensuel Gratification M2- 07/08/2023- Institut de Biochimie et Génétique Cellulaires, CNRS UMR5095- Lieu de travail- Bordeaux Nouvelle Aquitaine France- Champs scientifiques- Biologie
- Physique
**Établissement recruteur**:
**Site web**:
**Description**:
A Master 2 internship is available in the SyntheCell group of Dr. Damien Coudreuse at the Institute of Biochemistry and Cellular Genetics in Bordeaux, France (CNRS UMR 5095). Our team investigates how cellular aging in eukaryotes may be shaped by the morphological features and internal biophysical properties of cells.
Cell growth and proliferation are central to all living species. However, eukaryotic cells can also exit the cell cycle and enter a non-dividing state known as quiescence. Remarkably, the capacity of quiescent cells to re-enter the cell cycle and proliferate when exposed to favorable conditions slowly diminishes with time. This common phenomenon is referred to as chronological aging and has a strong impact on cell biology in both normal and pathological contexts. However, how cellular lifespan is shaped by the physiological changes that occur during aging remains poorly understood. Intriguingly, our unpublished data suggest that the biophysical properties of aging cells play a key role in defining cellular lifespan, revealing an unanticipated dimension in the regulation of chronological aging in eukaryotic cells.
Intracellular biochemistry and the reactions that underlie cellular processes are shaped by physical parameters such as diffusion and molecular crowding. These features of both the cytoplasm and nucleus affect virtually all aspects of cellular function. Remarkably, when yeast cells exit the cell cycle and age, they undergo a drastic rigidification of their cytoplasm and a reduction of its diffusivity. This project will take advantage of multi-disciplinary approaches to map different aspects of intracellular fluidity in non-dividing aging cells.
This research will be based on fission yeast models that were developed in the team using a synthetic biology strategy. Importantly, these unique models will allow us to address questions that cannot be investigated in other complex systems. Given the ubiquitous nature of chronological aging and the conservation of the processes that regulate cell proliferation among eukaryotes, this study will provide novel insight into the way the physical chemistry of the cells impacts decision-making processes in changing environments and help us better understand the mechanisms of cellular aging that lie at the interface of biology and physics.
**Profil**:
**Prise de fonction**:
- 08/01/2024
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