Synthetic Approaches for The Preparation of New

il y a 3 semaines


Villeurbanne, France ICBMS Temps plein

**Synthetic approaches for the preparation of new galactoglycerolipids and other lipids esterified with ω3/6 polyunsaturated fatty acid**:

- Réf
- **ABG-112887**
- Sujet de Thèse- 04/04/2023- Contrat doctoral- ICBMS- Lieu de travail- VILLEURBANNE - Auvergne-Rhône-Alpes - France- Intitulé du sujet- Synthetic approaches for the preparation of new galactoglycerolipids and other lipids esterified with ω3/6 polyunsaturated fatty acid- Champs scientifiques- Chimie

**Description du sujet**:
Mono/di-galactosyl diacylglycerol (MGDG and DGDG) branched with the same fatty acid or with mixed fatty acids are of biological interest in particular regarding their nutritional properties. The PhD proposal will be focused on synthetic challenges toward the development of synthetic method for the preparation of these compounds. In particular, the synthesis of galactoglycerolipids branched with natural or unnatural ω3/6 polyunsaturated fatty acids will be investigated. The total synthesis of ω3/6 polyunsaturated fatty acids still remains a challenge in organic chemistry. The present project aims also to develop a flexible synthesis of these fatty acids using a method allowing chain elongation of alkyne derivatives followed by a coupling reaction and subsequent reduction to provide the corresponding unsaturated fatty acid esters. The preparation of new triglycerides as well as phospholipids esterified with ω3/6 polyunsaturated fatty acids will be also undertaken. The synthetic lipids in particular mono/di-galactosyl diacylglycerol (MGDG and DGDG) will be studied in collaboration with academic partners.

**Nature du financement**:

- Contrat doctoral**Précisions sur le financement**:
**Présentation établissement et labo d'accueil**:

- ICBMSL’Institut de Chimie et de Biochimie Moléculaires et Supramoléculaires (ICBMS) dépend de 4 tutelles (Université Lyon1 / CNRS / CPE -Lyon / INSA Lyon). Réparties sur deux sites et hébergées dans 3 bâtiments, ses 12 équipes (et leurs 150 chercheurs) sont soutenues par 2 centres communs (RMN et Spectrométrie de Masse) et une chimiothèque.

Axes étudiés:
Axe 1 : Chimie vers l’environnement

Axe 2 : Méthodologies de synthèse

Axe 3 : Chimie à l’interface avec le vivant

Axe 4 : Biochimie et biologie moléculaire

**Site web**:



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