Voir plus Effondrement

Postdoctoral Position On Gliovascular Unit of

il y a 1 mois

Rouen, France University Rouen Normandie Temps plein

**NeuroGlio**
**Genetics, Biology and Plasticity of Brain Tumors Team**
Cancer and Brain Genomics, U1245 Inserm, Institute for Research and
Innovation in Biomedicine. Rouen Normandy University France

**Postdoctoral Position on Gliovascular Unit of Glioblastoma**
Team leader and Co-funder of the Cancer and Cognition Platform
**Funding**: National Cancer Institute (INCa), Ligue contre le cancer charity and ARC foundation.
**Duration**: 2 years

We are looking for a motivated and expert post-doc to join our team within the genetic and translational expert research Cancer and Brain Genomics INSERM unit, to work on the
GlioVasc PAIR Brain Tumor project (7 French teams). The global aim of the whole program is to elucidate the key features of the gliovascular unit and its pivotal role in glioblastoma (GB) recurrence and treatment resistance. We propose to explore the dynamic trajectories of the GB and stromal cells within the gliovascular unit from human GB samples and their molecular underpinnings during the Stupp protocol. Our NeuroGlio team will map the gliovascular unit heterogeneity phenotypically (organoids) and at the single cell level in GB patients and carry some gene targets validation in GB resection preclinical models.

**Proposed approaches**:Organoids (GBO) and gliovascular units (GBV) have already been implemented in the team from GB patient samples and from murine GB xenografts, and have been verified for maintenance of intra-tumor heterogenous cell composition and proliferation status. Some selected samples will be prepared for RNAseq/ATACseq analyses through the facilities of the Institute for Research and Innovation in Biomedicine of the Rouen Health
Institute site. Patient derived cell lines generated will also be generated to compare with gliovascular single-cell transcriptomics and epigenomics data of GB samples and for validation studies. In preclinical models of GB resection, GB heterogeneity and microenvironmental cells organization and composition will be systematically characterized by 2D and 3D imaging
(iDISCO and CLARITY) through local expert facilities (HeRacLeS) of Rouen.

**Team’s research programs**:We bring into play our competences in the field of
Neuroscience and Neuro-oncology in a very expert environment in the genetic predisposition of tumors, neuronal and neurodevelopmental pathologies. Our team aims to characterize new therapeutic targets in the context of brain tumors and to evaluate the brain sequelae related to cancer and cancer treatments, between therapeutic efficacy and preservation of brain functions. The strength lies in our expertise in molecular and cellular biology of migration and invasion of glioma cells and in the design and validation of dynamic cellular imaging tools. We also set up behavioral mouse models with cancer and after resection microsurgery, and during conventional treatments or immunotherapy. Neuroscience tools
(electrophysiology/optogenetics) are developed on organotypic GB slices and _in vivo_ GB mouse models. Then, clinical protocol and methodologies to establish GB organoids from patients and cerebroids from human iPS cells are currently leveraged in the team.

Imaris software, human scRNAseq analyses and in _in vivo_ preclinical models of GB growth.
Experience in bioinformatics would be much appreciated. He/she would be fluent in both spoken and written English.

Type d'emploi : Temps plein
Statut : Cadre

Salaire : 2 200,00€ par mois

Exigences linguistiques flexibles:

- Français non requis

Programmation:

- Travail en journée

Lieu du poste : En présentiel

Nous avons d'autres emplois actuels liés à ce domaine que vous pouvez trouver ci-dessous

  • Post-doctoral Position Human Glioma Tumoroids

    il y a 4 semaines

    Rouen, France University Rouen Normandie Temps plein

    **Genetics, Biology and Plasticity of Brain Tumors Team** Cancer and Brain Genomics, U1245 Inserm, Institute for Research and Innovation in Biomedicine. Rouen Normandy University France **NeuroGlio Team** Team leader and Co-funder of the Cancer and Cognition Platform **Funding**: National Cancer Institute (INCa), Ligue contre le cancer charity and ARC...

  • Post-doctoral Position Human Glioma Tumoroids

    il y a 4 heures

    Rouen, France University Rouen Normandie Temps plein

    **Genetics, Biology and Plasticity of Brain Tumors Team** Cancer and Brain Genomics, U1245 Inserm, Institute for Research and Innovation in Biomedicine. Rouen Normandy University France **NeuroGlio Team** Team leader and Co-funder of the Cancer and Cognition Platform **Funding**: National Cancer Institute (INCa), Ligue contre le cancer charity and ARC...

  • Postdoc or Engineer

    il y a 2 semaines

    Rouen, France Université de Rouen Normandie Temps plein

    **2 Postes à pourvoir**: - **Chercheur postdoctoral**: - **Assistant Ingénieur** **Biologie Cellulaire / Biologie moléculaire / Immunologie / Cancer / Biothérapie** **Suivi des réponses immunitaires /Réponses antitumorales/ Expérimentation animale** **H/F CDD 35h, 24 mois renouvelable, poste à pourvoir dès que possible** L’unité Inserm U1234...

  • Responsable D'unités Sociales Et Médico-sociales

    il y a 3 semaines

    Rouen, France IDEFHI Temps plein

    **L’Institut Départemental de l’Enfance, de la Famille et du Handicap pour l’Insertion** 2ème établissement social et médico-social public, l’IDEFHI accueille environ 1550 usagers relevant du secteur de la protection de l’enfance ou du handicap, implanté sur l’ensemble du territoire départemental de Seine Maritime. Les services de...

  • Deep Learning for The Next Generation of Cellular

    il y a 2 semaines

    Rouen, France Université de Rouen Normandie - Institut National des Sciences Appliquées (INSA) - LABORATOIRE de re Temps plein

    **Deep Learning for the next generation of cellular vehicular communications systems (6G-V2X)**: - Réf - **ABG-114424** - Sujet de Thèse- 13/05/2023- Contrat doctoral- Université de Rouen Normandie - Institut National des Sciences Appliquées (INSA) - LABORATOIRE de recherche LITIS- Lieu de travail- Rouen - Normandie - France- Intitulé du sujet- Deep...

  • Responsable D'unités Sociales Et Médico-sociales

    il y a 4 jours

    Rouen, Normandie, France IDEFHI Temps plein

    **L'Institut Départemental de l'Enfance, de la Famille et du Handicap pour l'Insertion**2ème établissement social et médico-social public, l'IDEFHI accueille environ 1550 usagers relevant du secteur de la protection de l'enfance ou du handicap, implanté sur l'ensemble du territoire départemental de Seine Maritime.Les services de protection de l'enfance...

  • Physical Failure Analysis of Mosfet Sic Transistors

    il y a 4 semaines

    Rouen, France Université de Rouen laboratoire GPM Temps plein

    **Physical failure analysis of MOSFET SiC transistors under ESD stress and Single Event Burnout**: - Réf - **ABG-114838** - Sujet de Thèse- 30/05/2023- Autre financement public- Université de Rouen laboratoire GPM- Lieu de travail- Rouen - Normandie - France- Intitulé du sujet- Physical failure analysis of MOSFET SiC transistors under ESD stress and...

  • Study of The Trap Phenomenon in Rf Gan Hemts

    il y a 2 semaines

    Rouen, France Université de Rouen Normandie Temps plein

    **Study of the Trap Phenomenon in RF GaN HEMTs Transistors: Electrical Characterization and Physical Simulation**: - Réf **ABG-121548** - Sujet de Thèse- 21/03/2024- Contrat doctoral- Université de Rouen Normandie- Lieu de travail- Rouen - Normandie - France- Intitulé du sujet- Study of the Trap Phenomenon in RF GaN HEMTs Transistors: Electrical...

  • Physical Failure Analysis of Mosfet Sic Transistors

    il y a 4 jours

    Rouen, Normandie, France Université de Rouen laboratoire GPM Temps plein

    Physical failure analysis of MOSFET SiC transistors under ESD stress and Single Event Burnout:Réf- ABG-114838 Sujet de Thèse 30/05/2023 Autre financement public Université de Rouen laboratoire GPM Lieu de travail Rouen Normandie France Intitulé du sujet Physical failure analysis of MOSFET SiC transistors under ESD stress and Single Event Burnout Champs...

  • chauffeur livreur pl

    il y a 5 jours

    Rouen, Normandie, France SUPPLAY ROUEN Temps plein

    About the Company:Major player in the temporary work and recruitment sector,Supplay continues to grow while maintaining a company culture based on respect and excellence. Every day, we balance the expectations of our clients with those of our temporary employees with agility and support them in their recruitment. Supplay is the first temporary employment...

  • Head of Marketing

    Il y a 2 mois

    Rouen, France TEAM IS Temps plein

    **Présentation de la société**: Lancé en 2021, **Team.is est** **u**ne start-up de recrutement spécialisée** dans la chasse et le recrutement de profils IT, Digital, Ingénierie & Supply Chain. **Team.is c'est avant tout une entreprise à taille humaine animée par la passion du recrutement !** **Description**: **En postulant à cette offre, vous...

  • Juriste droit des sociétés H/F

    il y a 4 jours

    Rouen, Normandie, France Nextep HR ROUEN Temps plein

    About the Company:Nextep HR, a branch of Domino RH, is a recruitment and direct approach agency specializing in temporary and permanent contract recruitments, using its expertise to serve all types of companies: tertiary, industrial, construction, IT... from small businesses to large corporations. Currently, we are looking for a skilled legal expert in...

  • Opérateur mouvement

    il y a 5 jours

    Sotteville-lès-Rouen, Normandie, France MyJobCompany Temps plein

    INTERACTION ROUEN is looking for a Movement Operator for its client, a French public railway company, in a temporary position. This is a great opportunity to join a team dedicated to operational excellence in the railway sector. You are responsible for train punctuality.You perform necessary railway maneuvers for setting up train cars for maintenance...

  • Chargé de La Coordination Parcours Vers L'emploi

    il y a 5 jours

    Rouen, France Artisanat Temps plein

    **Le contrat**: CDD (Contrat à durée déterminée) - Salaire - 2145.00€ - Avantages Date de prise de fonction : 19.06.2024 - Lieu - Campus Simone VEIL ROUEN La CMA Normandie recrute un Chargé de la coordination parcours vers l'emploi H/F pour son Campus Simone VEIL de Rouen dans le cadre d'un CDD jusqu'au 31/07/2024 **Missions**: - Rattaché au...

  • Prescriber M/w

    il y a 2 semaines

    Rouen, France PPG Industries Temps plein

    As a **Prescriber M/W**, you ensure prescription actions and the promotion of the Seigneurie Gauthier brand in your sector and you bring business to the sales team and customers in your sector. Report to the Sales Manager. This job is remote-friendly #Li-remote Main missions: - Develop a relational network with sector influencers. - Provide technical and...

  • QA Engineer validation project

    il y a 3 semaines

    Rouen, France Novo Nordisk AS Temps plein

    Are you passionate about the pharmaceutical industry? Do you want to contribute to a global program involving multiple sites worldwide? Would you like to be part of a rapidly expanding company? If so, you might be the person we're looking for! Our opportunity is based at the Chartres production site, which is undergoing a massive investment of 2.1...

  • Assistant D'agence Polyvalent

    il y a 3 semaines

    Rouen, France Avis Budget Group Temps plein

    **Rental Sales Agent** Immediately hiring! We are now seeking passionate, energetic and motivated people, like you, to join our growing Avis Budget Group enterprise. We’ll help you reach your full potential by developing, rewarding and inspiring you to maximize your earnings in a friendly and empowering sales environment. **What You’ll Do**: You will...

  • Import Logistics Specialist

    il y a 3 semaines

    Rouen, France The Lubrizol Corporation Temps plein

    About Lubrizol The Lubrizol Corporation, a Berkshire Hathaway company, is committed to enabling a sustainable future. Our unmatched science unlocks immense possibilities at the molecular level, driving sustainable and measurable results to help the world Move Cleaner, Create Smarter and Live Better. Our solutions are used by people every day, improving...

  • Chargé de La Coordination Du Parcours Vers L'emploi

    il y a 7 jours

    Rouen, France CMA Normandie Temps plein

    Rattaché au Responsable du développement du site de formation d’apprentis, vos missions sont les suivantes: - Animer des réunions d’information - Faire passer des tests de positionnement et en analyser les résultats - Conduire des entretiens individuels de positionnement - Prescrire des parcours de prépa-apprentissage en lien avec le responsable...

  • International Sales

    il y a 7 jours

    Rouen, France Digital Yacht Temps plein

    **International Sales & Marketing (Alternance, Apprenticeship or Internship)** Digital Yacht is all about next generation navigation, communication and entertainment systems for the boat. Boating should be fun, safe and easy. Our products integrate into existing and new boat networks to bring a powerful dimension to your on-board...