Phase Contrast and Dark-field Imaging On Highly
Il y a 2 mois
**Phase Contrast and Dark-field Imaging on highly absorbing materials using Laboratory X-ray sources**:
- Réf
- **ABG-114817**
- Sujet de Thèse- 29/05/2023- Autre financement public- Université Grenoble Alpes- Lieu de travail- Grenoble - Auvergne-Rhône-Alpes - France- Intitulé du sujet- Phase Contrast and Dark-field Imaging on highly absorbing materials using Laboratory X-ray sources- Champs scientifiques- Physique
**Description du sujet**:
**Background**
- X-ray Phase Contrast (PC) and Darkfield Imaging (DI) have been demonstrated to outperform conventional 3D imaging modalities based on the sole attenuation. However, these techniques are presently available mainly at synchrotrons at the high energy needed to image metals or human anatomical pieces in 3D. Their access and dissemination are therefore extremely limited. The main aim of this Ph.D is to initiate the transfer of PCDI Computed tomography in a laboratory setting to build.- Briefly, Image contrast in PCDI arises from the deviation of X-rays passing through materials with different electron densities. These deviations are indicated respectively as a) refracted or b) scattered X-rays depending on the number of traversed interfaces. The so-called “refracted” X-rays deviate within micro
- to milli-radians from the original direction; PC refraction images map the distribution of the refraction properties of the sample, defined by the real term of the refraction index. Scattered X-rays deviate instead several dozen or hundreds of milli-radians from their original directions; PC images mapping the scattering are indicated as “dark field” images; scattering arises from inhomogeneities in the sample and/or the presence of many interfaces, due to local small porosity (equivalent to, or smaller than the pixel).**Objectives**
- The objective of this project will be to optimize the components and experimental parameters so that PCDI can be performed on a laboratory optical line on highly absorbing materials. This work of simulation and experimental validation will be completed by the development of data processing algorithms taking into account the limitations of laboratory equipment (source emission spot size, beam hardening, limited propagation distance....) to get as close as possible to the results obtained on synchrotron.- Therefore this PhD work can be described in two main objectives- **Development of iterative reconstruction algorithms**: measurements performed on laboratory equipment are degraded compared to data acquired on synchrotron. The characteristics of the various components will be modeled and integrated into the phase and dark field reconstruction algorithms. In particular, it is planned to integrate the characteristics of the source (emission spectrum, stability, focus size) and the modulator (geometry, material, stability). The 3D reconstruction (tomography) from the phase and dark field images will also be studied, by integrating additional parameters (correction of the rotation axis, taking into account the beam hardening, movement of the source etc.).
- **Experimental validation**: After numerical simulation of the experiment with tools developed by Strobe laboratory, phase contrast and dark field imaging measurements will be performed on an on-purpose designed laboratory optical line, on samples of increasing complexity (spherical particles, composite materials, biological materials, metals). Comparative measurement campaigns on synchrotron will be organized to evaluate the performance of the laboratory line. The influence of the different components (source, modulator, optical line geometry, detector) and measurement parameters (exposure time, number of images, acquisition sequence) will be quantified and optimized.
**Method**
- The PhD will include the following steps:
- Introduction to PCDI theory and the purely numerical aspects. Summary of the advantages and disadvantages of the different phase contrast imaging techniques. Study of the different reconstruction algorithms adapted to laboratory sources.
- Identification/building of reference samples for comparative measurements on synchrotron and laboratory.
- Phase contrast and dark field imaging campaigns on a laboratory equipment, quantification of the errors related to each optical component and optimization of the experimental parameters.
- Modeling of the optical components in the phase and dark field reconstruction algorithms, to minimize the discrepancies between the laboratory results and the synchrotron results.
**Scientific and material conditions**
- For the experimental part, the project will use of the synchrotron beam and the new generation of laboratory device developed in the CDP MusitoX.- For the modeling part, some simulation tools are already available and can be exploited on the computing clusters of the UGA (mesocenter gricad)**Practical Information**
**Location**: Strobe Inserm UA7 - Université Grenoble Alpes 2280 rue de la piscine 38610 Gie
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