Light-driven Nanozyme

**Light-driven Nanozyme**:

- Réf **ABG-127376**
- Stage master 2 / Ingénieur- Durée 6 mois- Salaire net mensuel 600 euros- 04/12/2024- L2CM, Universite de Lorraine- Lieu de travail- Nancy Grand Est France- Champs scientifiques- Chimie
- Matériaux
- Mots clés- Enzyme-like, semi-conducteur materials, nanocatalytic therapy-
- 13/12/2024**Établissement recruteur**:
**Site web**:
**Laboratoire Lorrain de Chimie Moléculaire (L2CM) UMR 7053**

L'axe HéMaF (Hétérocycles et Matériaux Fonctionnels) et L'axe MolSyBio (Molécules et Systèmes Bioactifs)

**Description**:
**_Context_**. Today, the threat of antibiotic-resistance of pathogenic microorganisms requires the

development of alternative methods that do not lead to drug resistance. Phototherapeutic (PT)

strategies, recently established as a breakthrough in the field of photoreactive materials, have become

a new trend in the inactivation of pathogenic micro-organisms. Among them, photocatalytic

antimicrobial therapy (PCAT) has emerged as an effective and promising antimicrobial strategy in

recent years. In the PCAT process, photocatalytic materials are excited by different wavelengths of

light to produce reactive oxygen species (ROS) or other toxic species to kill various pathogenic

microbes, such as bacteria, viruses, fungi, parasites and algae.[1] Despite great efforts, designing and

developing antimicrobial materials that specifically and effectively self-supply H2O2 at the wound site

still challenging. In order to selectively increase the level of H2O2 in the biofilm, one approach is to use

glucose oxidase (GOx) to catalyse the oxidation of intracellular glucose to produce high levels of H2O2.

enzymes.[2] Moreover, the high-temperature induced by photothermal therapy would significantly

reduce the enzymatic activity of GOx.[3] Nanozymes with GOx-like activity hold great potential in

producing self-supplying H2O2 due to their high stability and the maintenance of activity over broad

ranges of temperature.[2] Therefore, it is

highly desirable to integrate nanozymes

into the construction of therapeutics to

bridge the gap between the self-supplied

of endogenous H2O2 and PCAT. However,

the main problem with nanomaterials is

their passive diffusion, which leads to poor

or non-existent interactions between the

materials and the pathogens. Therefore,

stimulating the mobility of these

nanomaterials helps overcome the current

problem of infection treatment. [4]

Your main **mission**:
Synthesis of materials, MoS2 in various shapes and g-C3N4.

Synthesis and characterization of heterojunctions.

Study the mechanism of the catalytic activities.

**Profil**:
**Prise de fonction**:

- 03/02/2024