PhD project on Vascular Calcification

il y a 1 jour


Montpellier, France RD Néphrologie SAS Temps plein

3-year PhD project for doctoral student in the H2020 Doctoral Network “LIPIDs as promising BRidge between novel disease InsiGHts and improved Tackling of disease” (LipidBRIGHT) in Montpellier (France). International mobility is mandatory. If you have been living in Francemore than 1 year in the past 36 months, you are not eligible for the position. Your objectives are To investigate the potential of pro-resolving lipids in preventing vascular calcification in the context of CKD, CVD and chronic inflammation in animal models, To decipher the underlying mechanisms of action using animal, ex vivo and in vitro models What you will do You will develop in vitro models (hAoSMCs culture) and ex vivo models (aortic ring culture) of vascular calcificationto test pro-resolving lipid activities. You will design and perform preclinical studies with CKD and/or vascular calcification rat models receiving pro-resolving lipids. You will assess the protective capacity of lipids on vessels (vascular calcification, inflammation, fibrosis, osteoblastic differentiation), kidney and heart (function, fibrosis, inflammation), as well as inflammatory cells (inflammatory mediators, macrophage infiltration/subset changes and neutrophil phenotyping). You will also evaluate the effects of protective lipids on inflammatory processes in established ex vivo and in vitro assays, and the on neutrophil NET production and resulting fibrin and clot formation. #J-18808-Ljbffr



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