System Development Engineer

POSITION TreeFrog Therapeutics is an innovative, international biotechnology company aiming to bring cell therapies to millions of patients using our C-STEM encapsulation technology, enabling large-scale amplification of iPS and differentiated cell products for patients. Using our C-STEM format, TreeFrog is currently developing multiple cell therapy programs for disease indications including Parkinson’s disease and acute liver failure. TreeFrog has also entered into a collaboration with Vertex Pharmaceuticals to incorporate C-STEM in the production of iPS-derived islets for type 1 diabetes. Find out more at our website: https://treefrog.fr Position: System Development Engineering – part of the System Engineering team whose mission is to bring disruptive technological modules developed by expert scientists into functional prototypes and early development systems. You will work at the interface of technical engineering and process/bio engineering, being involved in the innovation and development of engineering systems and solutions. Our main technology recently released from R&D stages, being deployed for cell therapy manufacturing under GMP (Good Manufacturing Practices) is an encapsulator for stem cells. You will be reporting directly to the System Engineering Team Manager. RESPONSIBILITIES As System Development Engineering, you will be involved in developing, testing, and validating encapsulation technologies and their submodules with a strong focus on reliability demonstration. The role includes leading the design and testing of sub‑modules, working collaboratively with internal teams and external stakeholders. You will design experimental plans, test methods and use statistical analysis for both prototypes and final systems to ensure system robustness and long‑term performance. Your missions will be: 1. Perform experiments of submodules for encapsulation technology (80%) Plan, execute and lead experimental campaigns of sub‑modules prototypes, both internally and with external partners, to support the development and verification of technologies. Develop and implement rigorous experimental plans (DoE), test protocols, and verification methods to characterize system performance, reliability, and robustness under all operating conditions. Apply risk‑based approaches (DFMEA) to identify and mitigate potential reliability issues early in the design process. Conduct stress, testing under limits, and extreme conditions to identify potential failure modes and performance boundaries. Analyze data using statistical and reliability tools to extract actionable insights and quantify confidence and performance. Document findings in detailed technical reports and present results, recommendations, and design implications to cross‑functional teams. 2. Coordinate and develop tools and test benches (20%) Coordinate prototype development activities with external design offices and internal stakeholders. Together with mechanical engineering, design and build custom test benches and data acquisition systems to evaluate sub‑module robustness, repeatability, and long‑term stability. Contribute to the definition of system‑level reliability validation plans and statistical test strategies for new developments. PROFILE As a trained engineer (Generalist Engineering, Applied physics engineering, Fluid mechanics engineering or Mechanical engineering) with 3‑5 years of experience in the industry, you have hands‑on experience and engineering knowledge with instrumentation including sensor integration, calibration, data acquisition. You have proven experience in system testing, experimental design and reliability engineering. You have a solid background in fluid mechanics and its application to complex mechatronics systems. You worked on developing complex systems and have both experimental and project management skills with knowledge of system design principles across mechanical, electrical and automation domains (multidisciplinary understanding is a plus). You are proficient in data analysis and statistical tools (Python, MATLAB, Prism) and have demonstrated analytical and problem‑solving skills with a structured and data‑driven approach. You are fluent in English. You are strongly motivated to solve complex problems with elegant and simple engineering solutions. Guided by the 20% effort / 80% results principle, you are comfortable managing multiple projects and interlocutors simultaneously. You have a solid engineering and project management record, and you are autonomous, conscientious, and feel capable of developing long‑term projects in an innovative environment. Proficiency, common sense, rigor, versatility, curiosity, adaptability, adventure and team spirit are key for you. Join us as a Froggy in TreeFrog. WORK ENVIRONMENT & CONDITIONS Contract: CDD or CDI Moving assistance: If you don't live near Bordeaux, we can help you find accommodation via a financial package. Sustainable Mobility: We promote soft mobility through our partner Bee‑cycle, which offers a solution to help our employees purchase a bike, and Karos, which is a car‑sharing solution, and we reimburse all transport‑related season tickets up to 50%. Ecological commitment: TreeFrog wants to save lives, but also help save our planet. Several of our employees are working together to reduce our waste and carbon emissions. For example, we have a zero‑waste connected fridge. Sport: CrossFit classes are held several times a week on our premises. Food: We offer meal vouchers worth €9.80, 60% of which is paid for by the employer. We also have a number of delivery options for high‑quality, low‑cost meals on our premises. English/French lessons: TreeFrog Therapeutics is a French company with a lot of written communication in English/French. Subscriptions to Babel or English courses are available for those wishing to improve their level of English/French. #J-18808-Ljbffr