Postdoctoral Researcher in Computational Biology
il y a 3 semaines
Institut Curie is a leading research and medical center dedicated to the fight against cancer. With a strong international presence, our team of over 1000 employees is committed to advancing cancer research and improving patient care.
Our Research Center focuses on developing basic research and translating knowledge into innovative treatments for cancer patients.
MissionThe Cavalli Lab is seeking a highly motivated and talented scientist to join our team as a Postdoctoral Fellow.
We are part of the "Bioinformatics and Computational Systems Biology of Cancer" Unit (U900 INSERM, Mines ParisTech, Institut Curie), a dynamic and interdisciplinary team of bioinformaticians, biologists, physicians, mathematicians, statisticians, physicists, and computer scientists.
Our research focuses on tumor heterogeneity, targeting clinically relevant questions. We use patient samples profiling, investigating temporal and intra-tumoral/spatial heterogeneity as well as tumor/tumor microenvironment interactions in adult gliomas and pediatric brain tumors.
The ProjectWe are seeking a highly motivated individual to join our ENCOURAGER project, a collaborative effort funded by Fight Kids Cancer. This project aims to study the causes of resistance to targeted therapy in pediatric gliomas.
The successful candidate will investigate the longitudinal evolution of gliomas under treatment with the analysis of multi-omic profiling of pediatric glioma PDX models at single-cell resolution. This project is in close collaboration with Dr. Ana Guerreiro Stücklin lab at University Children's Hospital Zurich.
ResponsibilitiesDrive and develop a scientific project focused on tumor heterogeneity/treatment resistance
Perform end-to-end data analysis: QC, processing, results, visualization, interpretation...
Analyze single-cell RNA-seq and single-nucleus ChIP-seq datasets
Perform high dimensional data analysis and integrative 'omic' data analysis
Use and develop methods and strategies to investigate treatment resistance mechanism
RequirementsPhD in bioinformatics, statistics or computer science with knowledge and interest in biology
Have a track record of creativity in developing analytic strategies
Strong foundation of knowledge in one or more of the following: genomics, cancer biology, statistics
Have evidence of scientific accomplishment via peer-reviewed publications
Excellent computational skills
Experience working in a Unix environment
Experience in statistical analysis using R
Experience with high-throughput sequencing data analysis
Experience with single-cell RNA-seq analysis is desirable
Proficiency in English and excellent scientific writing skills
Understanding of cancer cell biology is an asset as well as experience of collaboration with biologists for solving concrete biological problems
What We OfferFixed-term contract
Starting date: as soon as possible
Duration: 18 months
Full-time position
Remuneration: according to the current grids
Benefits: Collective catering and 70% reimbursement of annual travel costs, company health insurance scheme
Location: Saint-Cloud near public transportations
How to ApplyPlease send your CV, letter of motivation and contact information of 3 referees, to Dr. Cavalli
Deadline for application: Nov 30th, 2024
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