PhD Positions in Transcriptional Noise Research
il y a 1 mois
We are seeking highly motivated PhD students to join our training network on transcriptional noise in development and disease. Our research focuses on understanding the mechanisms and functions of transcriptional noise in living cells.
Research Projects- Mathematical Modelling of HIV-1 Transcription: We will investigate the contribution of extrinsic and intrinsic noise to HIV-1 transcriptional bursts using single molecule methods and mathematical models.
- Impact of Paused Polymerase on Transcriptional Noise: This project will decipher the impact of paused polymerase on transcriptional noise in Drosophila embryos using quantitative live imaging and mathematical approaches.
- Impact of Chromatin Compaction on Transcription Noise: We will study the impact of local chromatin states on transcriptional noise in heterochromatic regions of live Drosophila embryos.
- Stochastic Transcriptional Bursting in Space and Time: This project will investigate the impact of pioneer factors on transcriptional bursting in single cells using quantitative live imaging and signal processing approaches.
- Strong background in biology, mathematics, or a related field
- Excellent programming skills
- Experience with quantitative imaging and mathematical modelling is a plus
Applicants should submit their CV, publications, and a summary of their research experience to the corresponding PI. The deadline for application is May 25th, 2020.
Funding is provided for 3 years. The training network will provide common activities, interdisciplinary training, and an environment uniting biologists and mathematicians.
Key words: transcription, imaging, quantitative biology, modeling, developmental biology, HIV-1, heterochromatin.
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