Postdoctoral Researcher

il y a 4 semaines


Palaiseau, Île-de-France INRIA Temps plein

Context and Opportunities

INRIA, the French national institute for research in computer science, control, and applied mathematics, is seeking a highly skilled researcher to join our team. Our research focuses on the intersection of mathematical biology, statistics, control engineering, and statistical physics applied to problems in biology.

Research Project

The objective of this project is to develop and implement sensitivity estimation methods for continuous-time Markov chain models of biochemical reactions coupled to the dynamics of growing populations. We will also construct a stochastic model of the repressilator gene circuit in bacteria based on single-cell microscopy data and apply sensitivity estimation methods to better understand the impact of growth on the circuit's functionality.

Main Activities

  • Develop sensitivity estimation methods for multi-scale stochastic models using the Girsanov measure transformation and finite difference methods.
  • Test methods on several toy examples.
  • Analyze microscopy data from collaborators.
  • Construct a stochastic model of the repressilator gene circuit using microscopy data.
  • Apply sensitivity estimation methods to the model.

Required Skills

  • Strong programming skills.
  • Prior experience with single-cell microscopy data.
  • Prior experience with continuous-time Markov chain models of chemical reactions.
  • Prior experience with sensitivity analysis.

Benefits

  • Subsidized meals.
  • Partial reimbursement of public transport costs.
  • Leave: 7 weeks of annual leave + 10 extra days off due to RTT (statutory reduction in working hours) + possibility of exceptional leave.
  • Possibility of teleworking and flexible organization of working hours.
  • Professional equipment available.
  • Social, cultural, and sports events and activities.
  • Access to vocational training.
  • Social security coverage.

Remuneration

According to profile.



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