Postdoctoral Researcher in Transcriptional Regulation of Neural and Immune Development

il y a 2 semaines


Strasbourg, Grand Est, France IGBMC Temps plein
Research Opportunity

The IGBMC is seeking a highly motivated postdoctoral researcher to join our team studying the cross-talk between macrophages and the intestine epithelium during enteric infection using Drosophila melanogaster as a model organism.

Project Overview

The project aims to decipher the mechanisms regulating the intestine resilience after enteric challenges in adult Drosophila. Our laboratory has identified different subgroups of macrophages in Drosophila displaying specific properties, and we are seeking to identify the macrophage subgroup(s) interacting with the intestine and the molecular pathways involved in the process.

Responsibilities
  • Characterize the signalling pathways involved in the intestine/macrophage interaction leading to the thinning of the epithelium using single cell sequencing and spatial transcriptomic techniques.
  • Utilize the extensive genetic toolbox available in Drosophila to investigate the molecular mechanisms underlying the intestine/macrophage interaction.
Requirements

The ideal candidate should have a strong interest in innate immunity and extensive experience in molecular biology and next generation sequencing. Previous experiences in Drosophila and confocal microscopy are recommended but not required.

Working Conditions

The postdoctoral contract is for 2 years extendable and will start from October 2024 on. The working language of the laboratory is English, and the IGBMC is a joint research unit between CNRS, INSERM, and University of Strasbourg.



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