Bioinformatics Researcher

il y a 3 semaines


Paris, Île-de-France Imagine - Institut des maladies génétiques Temps plein
About the Position

We are seeking a talented bioinformatician to join our research team at Imagine - Institut des maladies génétiques.

The ideal candidate will have experience in analyzing and integrating omics data, including WGS, RNA-Seq, and proteomics from patient cells, kidney organoids, and mouse models.

The successful candidate will work closely with biologists and other bioinformaticians involved in the consortium to analyze scRNASeq and snRNASeq data, assess the impact of therapeutic interventions, identify target cell populations, and evaluate single-cell responses and immune cell involvement.

Key Responsibilities
  • Analyze and integrate omics data, including WGS, RNA-Seq, and proteomics
  • Work closely with biologists and other bioinformaticians to analyze scRNASeq and snRNASeq data
  • Assess the impact of therapeutic interventions and identify target cell populations
  • Evaluate single-cell responses and immune cell involvement

Requirements

  • Bioinformatic analyses of NGS data (WES, WGS, ATAC-seq, RNAseq)
  • Familiarity with scRNA-seq data analysis
  • Statistical analyses of Omics data (GWAS, enrichment analysis, differential gene expression analysis)
  • Knowledge of machine learning
  • General knowledge and interest in genetics and molecular biology

Preferred Qualifications

  • Mastery of Unix/Linux environment and programming languages (Python, R)
  • Proficiency in exome/genome analysis, including variants annotation and prioritization
  • Knowledge of public genomic databases (NCBI, GenCode, gnomAD, Biomart, etc.)
  • Data management skills for large-scale datasets
  • Report writing and presentation skills in English and French


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