Bioanalyst Researcher in LC-MS/MS
il y a 4 semaines
AB Science is a pharmaceutical company dedicated to the development of innovative drugs for human and veterinary medicine.
The company has a comprehensive clinical development program in neurodegenerative diseases, oncology, and inflammatory diseases.
AB Science is committed to promoting professional equality between women and men, considering it a key factor in the company's performance and modernity.
The company values employee diversity as a source of wealth and a means to strengthen social cohesion.
Job Description:
AB Science is seeking a Research Technician or Engineer in bioanalyses by LC-MS/MS for its new Early ADME/DMPK department.
Missions:
- Develop and validate methods for the determination of small chemical molecules by Ultra High Performance Liquid Chromatography (UHPLC) coupled with LC-MS/MS tandem mass spectrometry.
- Perform in vitro biology experiments to evaluate the physico-chemical and ADME properties of molecules from our medicinal chemistry laboratories, including solubility, pKa, LogP, LogD, permeability/carriers, metabolic stability, and plasma protein binding.
- Analyze samples from in vitro biological experiments on a routine basis.
- Routine analysis of biological samples from in vivo biological experiments, determination of pharmacokinetic parameters, biomarker analysis, and data quality control.
- Write and re-read procedures.
- Participate in the proper functioning of the laboratory, maintenance of equipment, and qualification.
Requirements:
- Scientific training (bac+2/3 to bac+5) in Analytical Chemistry or Biochemistry.
- Minimum of 2+ years of industrial or academic experience in Bioanalysis on a similar position.
- Knowledge of LC-MS/MS and sample preparation (solid phase extraction, liquid-liquid extraction) as well as experience in UHPLC analysis with mass spectrometry detection.
- Proficient in scientific English and computer tools (Empower, Mass Lynx, Analyst, Mass Metasite).
- Highly organized and able to work independently.
- Ability to work on multidisciplinary projects.
Your analytical and synthesis capabilities, as well as the rigor of your work, will allow you to be an important player in the realization of ongoing projects.
Finally, your interpersonal qualities will enable you to be at ease in a team and also to be independent in your organization and work.
Terms and Conditions:
- Permanent contract (CDI, 35 hours/week).
- Paris South area (Evry genopole, Campus 1) based post office.
- Salary to be defined according to profile and experience.
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