Postdoctoral Researcher in Complement System Biology

Il y a 2 mois


Grenoble, Auvergne-Rhône-Alpes, France CEA Temps plein
Description de l'offre

Our team at the CEA is dedicated to advancing the understanding of the complement system and its structural components, with a primary focus on autoimmune and chronic inflammatory diseases. Our current projects explore:

The interplay between alarmins and the classical complement pathway.

The novel roles of C1 proteases in the development of renal cancer.

We are seeking a motivated and talented postdoctoral researcher to explore the antigenic determinants and the pathogenicity of the anti-C1q autoantibodies in systemic lupus erythematosus – a paradigm of disease of systemic autoimmunity.

Responsabilités clés

Recombinant Expression and Purification of C1q and its fragments: Initiate the project by producing and purifying complement C1q and its variants using advanced recombinant techniques.

ELISA Analysis: Utilize ELISAs to precisely identify the domains of C1q targeted by autoantibodies in sera from SLE patients and control groups.

Autoantibody Characterization: Conduct in-depth analysis of purified autoantibodies from SLE patient plasma to understand their interactions and implications in the disease pathophysiology.

Structural Exploration: Employ complementary structural approaches to explore how C1q conformation modulates epitope access and gain comprehensive insights into the behavior and function of C1q and their perturbation by autoantibody interactions.

Profil du candidat

Ph.D. in Biochemistry, Molecular Biology, or a related field.

Strong experience in recombinant protein expression and purification.

Proficiency in ELISA and other immunoassays.

Familiarity with structural biology techniques will be greatly appreciated.

Passion for scientific discovery and a collaborative spirit.



  • Grenoble, Auvergne-Rhône-Alpes, France CEA Temps plein

    Researcher in Complement System BiologyWe are seeking a highly motivated and talented postdoctoral researcher to join our team at the CEA, a leading research organization in France. Our team is dedicated to advancing the understanding of the complement system and its structural components, with a primary focus on autoimmune and chronic inflammatory...


  • Grenoble, Auvergne-Rhône-Alpes, France CEA Temps plein

    Research Project OverviewThe CEA is seeking a highly motivated postdoctoral researcher to contribute to our cutting-edge project on the complement system and its role in autoimmune diseases. Our team focuses on understanding the structural determinants of autoimmunity against complement C1q in lupus patients.Key ResponsibilitiesRecombinant expression and...


  • Grenoble, Auvergne-Rhône-Alpes, France CEA Temps plein

    Job Offer Our research team at the CEA is committed to advancing the understanding of the complement system and its structural components. We are seeking a highly motivated and talented postdoctoral researcher to explore the antigenic determinants and the pathogenicity of the anti-C1q autoantibodies in systemic lupus erythematosus. Key Responsibilities: ...


  • Grenoble, Auvergne-Rhône-Alpes, France CEA Temps plein

    Research Opportunities at CEAWe are seeking a highly motivated and talented postdoctoral researcher to join our team at the French Alternative Energies and Atomic Energy Commission (CEA). Our research focuses on advancing the understanding of the complement system and its structural components, with a primary emphasis on autoimmune and chronic inflammatory...


  • Grenoble, Auvergne-Rhône-Alpes, France CEA Temps plein

    Description de l'offreOur team at the CEA is dedicated to advancing the understanding of the complement system and its structural components. We are seeking a highly motivated and talented postdoctoral researcher to explore the antigenic determinants and the pathogenicity of the anti-C1q autoantibodies in systemic lupus erythematosus.Key...


  • Grenoble, Auvergne-Rhône-Alpes, France CEA Temps plein

    Job OpportunityWe are seeking a highly motivated Postdoctoral Researcher in Cell Biology to join our team at CEA. The successful candidate will contribute to the development of a vascularized islet model to understand the molecular mechanisms inducing type 1 diabetes.Project OverviewThis project involves the development of a pre-vascularized islet model, the...


  • Grenoble, Auvergne-Rhône-Alpes, France CEA Temps plein

    Job OpportunityWe are seeking a highly motivated postdoctoral researcher to join our team at the CEA, specializing in cell biology and vascularization. The successful candidate will contribute to the development of a vascularized islet-model to understand the molecular mechanisms inducing type 1 diabetes.Project OverviewThis project involves the development...


  • Grenoble, Auvergne-Rhône-Alpes, France CEA Temps plein

    Project OverviewThe CEA is seeking a highly motivated postdoctoral researcher to join our team in the field of vascular cell biology. The successful candidate will contribute to the development of a pre-vascularized islet model and analyze the vascular network development using advanced imaging techniques.Key ResponsibilitiesDevelop and characterize human...


  • Grenoble, Auvergne-Rhône-Alpes, France EMBL Temps plein

    Job Title: Postdoctoral Organic/Medicinal ChemistWe are seeking a highly motivated and experienced postdoctoral researcher to join our team at EMBL Grenoble. The successful candidate will contribute to the design, synthesis, and optimization of novel bioactive compounds.Key Responsibilities:Design and synthesize new bioactive compounds for various target...


  • Grenoble, Auvergne-Rhône-Alpes, France CEA Temps plein

    Research OpportunityThis position is part of a research project focused on developing a vascularized islet model to understand the molecular mechanisms of type 1 diabetes. The project involves the development of a pre-vascularized islet model, the creation of a permissive vascular microenvironment on-chip, and the analysis of vascular network development.Key...


  • Grenoble, Auvergne-Rhône-Alpes, France Embl-Ebi Temps plein

    Job Title: Postdoctoral Organic/Medicinal ChemistWe are seeking a highly motivated and experienced postdoctoral researcher to join our team at EMBL Grenoble. The successful candidate will contribute to the design, synthesis, and optimization of novel bioactive compounds.Key Responsibilities:Design and synthesize new bioactive compounds for various target...


  • Grenoble, Auvergne-Rhône-Alpes, France ESRF Temps plein

    Research Scientist Position in Structural BiologyWe are seeking a highly motivated and skilled Research Scientist to join our Structural Biology Group at the European Synchrotron Radiation Facility (ESRF). The successful candidate will contribute to a project focused on developing new methods for probing protein dynamics using single-crystal room temperature...


  • Grenoble, Auvergne-Rhône-Alpes, France ESRF Temps plein

    Research Scientist in Structural BiologyWe are seeking a highly motivated and skilled Research Scientist to join our Structural Biology Group at the European Synchrotron Radiation Facility (ESRF). The successful candidate will contribute to a project aimed at developing new methods for probing protein dynamics using single-crystal room temperature and...


  • Grenoble, Auvergne-Rhône-Alpes, France EMBL Temps plein

    Job Title: Postdoctoral Organic/Medicinal ChemistWe are seeking a highly motivated and experienced postdoctoral researcher to join our team at EMBL Grenoble. The successful candidate will contribute to the design, synthesis, and optimization of novel bioactive compounds.Key Responsibilities:Design and synthesize new bioactive compounds for various target...


  • Grenoble, Auvergne-Rhône-Alpes, France ESRF Temps plein

    Research Opportunity in Structural BiologyESRF is seeking a highly motivated PhD researcher to join our Structural Biology Group. The successful candidate will work on a project aimed at proposing a new paradigm in macromolecular crystallography (MX) by focusing on room temperature data collection and embracing complementary biophysical approaches.Key...


  • Grenoble, Auvergne-Rhône-Alpes, France ESRF Temps plein

    Research Scientist OpportunityWe are seeking a highly motivated and skilled Research Scientist to join our Structural Biology Group at the European Synchrotron Radiation Facility (ESRF). The successful candidate will contribute to a project focused on developing new methods for probing protein dynamics using single-crystal room temperature crystallography...


  • Grenoble, Auvergne-Rhône-Alpes, France ESRF Temps plein

    Research Scientist OpportunityWe are seeking a highly motivated and skilled Research Scientist to join our Structural Biology Group at the European Synchrotron Radiation Facility (ESRF). The successful candidate will contribute to a project focused on developing new methods for macromolecular crystallography, with a particular emphasis on room temperature...


  • Grenoble, Auvergne-Rhône-Alpes, France ESRF Temps plein

    Research OpportunityESRF is seeking a highly motivated PhD researcher to join the Structural Biology Group and contribute to a project focused on room temperature data collection and complementary biophysical approaches in macromolecular crystallography.Project OverviewThe project aims to propose a new paradigm in MX by combining single-crystal room...


  • Grenoble, Auvergne-Rhône-Alpes, France CEA Temps plein

    Research OpportunityThis project offers a unique chance to contribute to the development of a vascularized islet model, enabling the understanding of type 1 diabetes molecular mechanisms, screening of new therapeutic targets, and drug development, including immunological approaches.Project ContextDiabetes is a global pandemic affecting 463 million people...


  • Grenoble, Auvergne-Rhône-Alpes, France ESRF Temps plein

    Research OpportunityWe are seeking a highly motivated PhD student to join our team at the ESRF, a leading international research institute. The successful candidate will contribute to a project focused on identifying compounds that modulate the activity of the exotoxin A protein from Pseudomonas aeruginosa using a combination of AI-based virtual screening,...