Postdoctoral Researcher in Complement System Biology
Il y a 2 mois
Our team at the CEA is dedicated to advancing the understanding of the complement system and its structural components, with a primary focus on autoimmune and chronic inflammatory diseases. Our current projects explore:
The interplay between alarmins and the classical complement pathway.
The novel roles of C1 proteases in the development of renal cancer.
We are seeking a motivated and talented postdoctoral researcher to explore the antigenic determinants and the pathogenicity of the anti-C1q autoantibodies in systemic lupus erythematosus – a paradigm of disease of systemic autoimmunity.
Responsabilités clésRecombinant Expression and Purification of C1q and its fragments: Initiate the project by producing and purifying complement C1q and its variants using advanced recombinant techniques.
ELISA Analysis: Utilize ELISAs to precisely identify the domains of C1q targeted by autoantibodies in sera from SLE patients and control groups.
Autoantibody Characterization: Conduct in-depth analysis of purified autoantibodies from SLE patient plasma to understand their interactions and implications in the disease pathophysiology.
Structural Exploration: Employ complementary structural approaches to explore how C1q conformation modulates epitope access and gain comprehensive insights into the behavior and function of C1q and their perturbation by autoantibody interactions.
Profil du candidatPh.D. in Biochemistry, Molecular Biology, or a related field.
Strong experience in recombinant protein expression and purification.
Proficiency in ELISA and other immunoassays.
Familiarity with structural biology techniques will be greatly appreciated.
Passion for scientific discovery and a collaborative spirit.
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Postdoctoral Researcher in Complement System Biology
il y a 3 semaines
Grenoble, Auvergne-Rhône-Alpes, France CEA Temps pleinResearcher in Complement System BiologyWe are seeking a highly motivated and talented postdoctoral researcher to join our team at the CEA, a leading research organization in France. Our team is dedicated to advancing the understanding of the complement system and its structural components, with a primary focus on autoimmune and chronic inflammatory...
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Postdoctoral Researcher in Complement System Biology
il y a 3 semaines
Grenoble, Auvergne-Rhône-Alpes, France CEA Temps pleinResearch Project OverviewThe CEA is seeking a highly motivated postdoctoral researcher to contribute to our cutting-edge project on the complement system and its role in autoimmune diseases. Our team focuses on understanding the structural determinants of autoimmunity against complement C1q in lupus patients.Key ResponsibilitiesRecombinant expression and...
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Postdoctoral Researcher: Complement System Biology
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Grenoble, Auvergne-Rhône-Alpes, France CEA Temps pleinJob Offer Our research team at the CEA is committed to advancing the understanding of the complement system and its structural components. We are seeking a highly motivated and talented postdoctoral researcher to explore the antigenic determinants and the pathogenicity of the anti-C1q autoantibodies in systemic lupus erythematosus. Key Responsibilities: ...
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Postdoctoral Researcher in Complement System Biology
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Grenoble, Auvergne-Rhône-Alpes, France CEA Temps pleinResearch Opportunities at CEAWe are seeking a highly motivated and talented postdoctoral researcher to join our team at the French Alternative Energies and Atomic Energy Commission (CEA). Our research focuses on advancing the understanding of the complement system and its structural components, with a primary emphasis on autoimmune and chronic inflammatory...
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Postdoctoral Researcher in Complement System Biology
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Grenoble, Auvergne-Rhône-Alpes, France CEA Temps pleinDescription de l'offreOur team at the CEA is dedicated to advancing the understanding of the complement system and its structural components. We are seeking a highly motivated and talented postdoctoral researcher to explore the antigenic determinants and the pathogenicity of the anti-C1q autoantibodies in systemic lupus erythematosus.Key...
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