Research Internship in Vascular Biology and Drug Discovery
il y a 3 semaines
We are seeking a highly motivated Master 2 student to join our research team at INSERM U955 - University Paris-Est Creteil. The successful candidate will contribute to our ongoing research project focused on the regulation of heme oxygenase-1 (HO-1) and its biological significance in vascular biology and drug discovery.
Project Overview
Our research team has made significant contributions to the understanding of the vasodilatory, anti-ischemic, and anti-inflammatory properties of carbon monoxide (CO). We have developed novel drug candidates that specifically target the heme oxygenase/CO pathway, and our work has shown efficacy against metabolic dysfunction, such as obesity and diabetes, as well as in inflammatory and vascular disorders.
Research Objectives
The successful candidate will be involved in the following research objectives:
- Assess CO delivery and accumulation in tissues in vivo
- Determine gene expression in various organs using RT-PCR techniques
- Analyze taxonomic microbial community using metabolomics and DNA-sequencing of faecal samples
Requirements
The ideal candidate should have basic knowledge of biology, pharmacology, and biochemistry, as well as some basic laboratory experience with knowledge in biochemical and molecular biology assays. Knowledge with in vivo experimentation is highly desirable.
What We Offer
We offer a dynamic and stimulating research environment, with opportunities for professional growth and development. The successful candidate will have the chance to work with a team of experienced researchers and contribute to cutting-edge research in the field of vascular biology and drug discovery.
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