Researcher in Organic Synthesis Position

il y a 2 semaines

Porcheville, Île-de-France Seqens Temps plein

Job Description

Family / Sub-family of employment

Corporate Innovation

Type of contract

Determinate contract

Duration of the contract (Months)

12 months

Job title

Researcher in Organic Synthesis (postdoc position) H/F

Job context :

This work will be carried out in collaboration between Prof Janine COSSY (ESPCI Paris) and Seqens (Dr Julien BOUTET. Sandrine GAUTHIER, Dr Pierre GILLES)

Main missions :

Development of Ene-REDuctases (ERED)-catalyzed reactions for the synthesis of bioactive compounds.

  • Initially, the candidate will spend few days at the R&D center in Nîmes (dedicated to biocatalysis) to get trained on the use of enzymes in organic chemistry. During the training, a screening of hundreds of ERED will be performed on model reactions to identify active and selective enzymes.
  • Then, with the active enzymes in hand, the candidate will develop a methodology of synthesis. The optimization of reactions conditions will be handled on a robotic platform (HTE High Throughput Experimentation and HTS High Throughput Screening) ensuring a fast and fine tuning of all the key parameters of the reactions. The reactions will be exemplified to several structures to address asymmetric synthesis of precursors of API.

Advantages for success :

  • PhD (or equivalent experience) in chemistry and have a good background in organic chemistry,
  • If possible, with an experience in enantioselective reactions,multistep synthesis of complex molecules and ideally in catalysis.
  • Familiar with the separation techniques, analytical methods (NMR, IR,UV, LC, GC, mass spectrometry ...)
  • Interest in new technologies like automatization of reactions, work at the interface of chemistry and biology.
  • Fluent in english and have the ability to work within a team and have good communication skills.

If you are interested, please include a cover letter, a CV, and two letters of recommendation with your application.

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