Postdoctoral Researcher in Transcriptional Regulation of Neural and Immune Development

il y a 7 jours


Strasbourg, Grand Est, France IGBMC Temps plein

The IGBMC is recruiting a postdoctoral researcher to study the cross-talk between macrophages and the intestine epithelium during enteric infection using the Drosophila melanogaster model. The project is funded by an ANR and is carried out in close collaboration with the team of Dr. Dominique Ferrandon.

The recruited researcher will integrate the team Transcriptional regulation of neural and immune development headed by Dr. Angela Giangrande and will be supervised by Dr. Pierre Cattenoz. The IGBMC is a joint research unit between CNRS, INSERM, and University of Strasbourg, with around 600 staff scientists.

The goal of the project is to decipher the mechanisms regulating the intestine resilience after enteric challenges in adult Drosophila. Data generated by our collaborator showed that the intestinal epithelium undergoes drastic thinning upon cytotoxic bacterial infection and recovers quickly after removal of the bacteria.

The recruited postdoc will use single-cell sequencing and spatial transcriptomics as well as the extensive genetic toolbox available in Drosophila to characterize the signalling pathways involved in the intestine/macrophage interaction leading to the thinning of the epithelium.

The postdoctoral contract is for 2 years, extendable, and will start from October 2024. Potential applicants should submit their applications to the IGBMC. For any question, do not hesitate to contact Angela Giangrande or Pierre Cattenoz.



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