Assessment of Thromboembolic Risk in the Left Atrium via 4D flow MRI and Computational Fluid Dynamics
il y a 2 semaines
Topic description Academic context: The research group at Mines Saint-Etienne leads major international research projects in the domain of soft tissue and fluid biomechanics in the cardiovascular system through a longstanding collaboration with the University Hospital in Saint-Etienne. This project will be a collaboration between Mines Saint-Etienne and TU Vienna and will include a short research stay at TU Vienna. This project also includes collaboration with the University Hospital of Saint-Etienne and the Hospital Clinic in Barcelona. Scientific context: Interest in Left Atrium (LA) biomechanics has increased in recent years, as impaired atrial function is strongly linked to a higher risk of stroke. Atrial Fibrillation (AF) accounts for about one-third of all strokes, but roughly 20% remain of unknown origin, suggesting other LA-related mechanisms. Blood stagnation caused by altered LA wall mechanics (e.g., fibrosis) may promote thrombo-embolic events. Understanding the coupling between LA biomechanics, remodeling, and intra-atrial hemodynamics is therefore crucial for assessing atrial function and stroke risk. This project aims to develop stroke-risk biomarkers based on 4D flow MRI and computational fluid dynamics (CFD). While advanced imaging has improved LA characterization, modeling provides complementary predictive insights. Project summary: This project will be based on a dataset of 4D flow MRI images of patients providing 3D blood velocity fields and LA wall motion. The approach will be divided into the following steps: Postprocessing of the 4D flow MRI images for the cohort Adaptation and application of highfidelity CFD simulations of intra-atrial hemodynamics Evaluation of the uncertainties of the 4D flow imaging approach: downsampling of the CFD simulations and comparison to in vivo 4D flow MRI data Evaluation of the predicting potential of the derived metrics: contrasting the in silico derived metrics with the clinical outcomes (occurrence of thromboembolic events). Combining insights from biomechanics and cardiovascular fluid dynamics with clinical data, this project aims to substantially enhance our understanding of Left Atrium biomechanics, while setting the foundation for a clinically translational approach to predict thrombosis risk in patients. Administrative aspects: This PhD position will be for 3 years, starting in the fall of . Funding category Public funding alone (i.e. government, region, European, international organization research grant) Funding further details
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Computational Fluid Dynamics Analyst IO1196
il y a 6 jours
Saint-Paul-lès-Durance, Provence-Alpes-Côte d'Azur, France ITER Organization Temps pleinApply today at: Grade: P2(NET Salary begins at €69,862, plus eligible allowances)(SALARY SIMULATOR)Application Deadline: 11/01/2026RELOCATION PACKAGES / COMPETITIVE SALARY / EXCELLENT BENEFITS / MEDICAL INSURANCE / 21% PENSIONAs aComputational Fluid Dynamics Analyst,your goals will include performing and verifying Computational Fluid Dynamics (CFD)...
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Computational Fluid Dynamics Analyst IO1196
il y a 6 jours
Saint-Paul-lès-Durance, Provence-Alpes-Côte d'Azur, France ITER Temps pleinFusion, the nuclear reaction that powers the sun and the stars, is a promising long-term option for a sustainable, non-carbon emitting global energy supply.The ITER Organization (IO), based in the southern France, welcomes best talents who can together prepare the way to this new energy in a truly multi-cultural work environment.We offer challenging...
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Computational Design Intern
il y a 5 jours
Saint-Ouen, France Samsung Electronics Temps pleinPosition Summary Location: Paris, France Duration: 6 months Start date: Flexible (February/March 2026) Position Summary Samsung Design Innovation Center (SDIC) is looking for a Computational Design Intern who is passionate about design, technology, and computational workflows. As part of the Computational Design team, you will work at the intersection of...
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Saint-Paul-lès-Durance, Provence-Alpes-Côte d'Azur, France CEA Temps pleinGeneral information Organisation The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :• defence and security,• nuclear energy (fission and fusion),• technological research for industry,• fundamental research in the physical sciences and life sciences.Drawing...
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Saint-Paul-lès-Durance, France CEA Temps pleinPosition description ** Category**: - Physics of the nucleus, atom, molecule ** Contract**: - Internship ** Job title**: - STAGE - Atomistic investigation of liquid metals in the context of nuclear accident scenarios H/F ** Subject**: - Atomistic investigation of liquid metals in the context of nuclear accident scenarios ** Contract duration...
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Saint-Paul-lès-Durance, Provence-Alpes-Côte d'Azur, France CEA Temps pleinPosition descriptionCategoryPhysics of the nucleus, atom, moleculeContractInternshipJob titleSTAGE - Atomistic investigation of liquid metals in the context of nuclear accident scenarios H/FSubjectAtomistic investigation of liquid metals in the context of nuclear accident scenariosContract duration (months)6Job DescriptionIn the context of nuclear accident...
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Saint-Étienne, France Institut Mines-Télécom Temps pleinJoining Mines Saint-Étienne means committing to an institution where **science and innovation build a more sustainable future**. It is a school of excellence where everyone has the **opportunity to unlock their full potential** and **contribute to tackling the challenges of tomorrow**. Ranked among the top engineering schools in France and recognized...
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Saint-Paul-lès-Durance, Provence-Alpes-Côte d'Azur, France CEA Temps pleinGeneral information Organisation The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :• defence and security,• nuclear energy (fission and fusion),• technological research for industry,• fundamental research in the physical sciences and life sciences.Drawing...
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Post-doctoral Position in Statistics Applied to
il y a 1 jour
38402 Saint-Martin-d'Hères, France INRAE Temps plein38402 _ **RETOUR À LA LISTE DES RÉSULTATS** **Présentation INRAE**: - The French National Research Institute for Agriculture, Food and the Environment (INRAE) is a public research establishment bringing together a working community of 12,000 people, with more than 200 research units and 42 experimental units located in the whole of France. INRAE is...
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Research Scientist
il y a 5 jours
Saint-Étienne, France Institut Mines-Télécom Temps plein**JOB ENVIRONMENT**: Mines Saint-Etienne (MSE), one of the graduate schools of _Institut Mines Télécom_, the #1 group of graduate schools of engineering and management in France under the supervision of the Ministry of the Economy, Industry and Digital Technology, is assigned missions of education, research and innovation, transfer to industry and...
