Miniaturized Fluidized Bed for The Efficient Capture of Pathogens

il y a 1 semaine

Saclay, France DRFJOLIOTSPI Temps plein

**Miniaturized fluidized bed for the efficient capture of pathogens**:

- Réf **ABG-131761**
- Sujet de Thèse
- 07/05/2025
- Financement public/privé
- DRF/JOLIOT/SPI
- Lieu de travail- SACLAY - Ile-de-France - France
- Intitulé du sujet- Miniaturized fluidized bed for the efficient capture of pathogens
- Champs scientifiques- Biologie
- Mots clés- Microfluidics;Biotechnology

**Description du sujet**:
Context of the project:
Sepsis is a generalized, inappropriate immune response to the presence of microorganisms in the blood. This condition is a major public health problem, accounting for over 11 million deaths worldwide every year. One of the reasons for this high mortality rate is the difficulty in rapidly identifying the pathogen at the origin of BSI, thus delaying the rapid administration of appropriate treatment.
This PhD project, in conjunction with the IHU PROMETHEUS, focuses on the development of miniaturized fluidized beds to concentrate blood biomarkers of sepsis, present in trace amounts in biological matrices. This method, based on the use of microfluidic technology, has the potential to replace lengthy blood culture methods, enabling rapid capture and subsequent identification of enriched targets. Thanks to their high flow rates, very large capture surface area and rapid exchange kinetics, the fluidized beds developed for nucleic acid capture will revolutionize the rapid diagnosis of BSI and prevent sepsis.
The LIFE project will be carried out through closed interactions between the LERI (immunoanalysis, in vitro diagnostics and rapid prototyping), and the LIONS (microfluidics, nanostructured materials and instrumentation) research groups, both located at the same site.
- Design and fabricate microfluidic devices in clean room and using rapid prototyping tools.
- Set up and optimize novel surface chemistry procedures on different substrates for target binding.
- Implement molecular biology tools and immunoassays to evaluate the performances of miniaturized device.
- Take an active role in the presentation and publication of research results.
- Be capable of working in a Level 2 biosafety laboratory.

**Nature du financement**:

- Financement public/privé

**Précisions sur le financement**:
**Présentation établissement et labo d'accueil**:

- DRF/JOLIOT/SPI

The Immunoanalysis Studies and Research Laboratory is located at the CEA, a major player in the field of research. For many years, the laboratory's activity has been based on the development of ELISA (enzyme-linked immunosorbent assays) and “strip” (chromatographic immunosorbent assays) rapid diagnostic tests in the fields of infectious diseases, personalized medicine and biodefense. LERI has expertise in the production, selection and characterization of the monoclonal antibodies needed to develop and market these tests.

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