Three-year Phd Position in Neurosciences:

il y a 2 semaines

Marseille, France Institut de Neurophysiopathologie Temps plein

**Three-year PhD position in Neurosciences: pathogenic mechanisms in Alzheimer's disease**:

- Réf **ABG-127081**
- Sujet de Thèse- 21/11/2024- Financement public/privé- Institut de Neurophysiopathologie- Lieu de travail- MARSEILLE - Provence-Alpes-Côte d'Azur - France- Intitulé du sujet- Three-year PhD position in Neurosciences: pathogenic mechanisms in Alzheimer's disease- Champs scientifiques- Psychologie, neurosciences
- Biologie
- Santé, médecine humaine, vétérinaire
- Mots clés- Alzheimer's disease, microglia**Description du sujet**:

- Alzheimer’s disease (AD) represents one of the most significant scientific and socio-economic challenges of the 21st century. Hallmarks of AD include aggregates of amyloid-β (Aβ) and tau proteins, as well as neuroinflammation and gliosis, which collectively lead to synaptic and neuronal loss, forming the basis of cognitive decline. While the mechanisms underlying neurodegeneration in AD remain incompletely understood, recent evidence highlights the pivotal role of microglial reactivity, influenced significantly by TREM2 and associated inflammatory responses. Both Aβ and tau pathologies exacerbate microglial reactivity, aggravating disease progression and neurodegeneration. However, the specific roles of microglia in Aβ- or tau-induced neurotoxicity remain unclear.- This study aims to investigate the proteomic changes in microglia caused by Aβ and tau pathologies, a critical step toward identifying potential therapeutic targets for halting or slowing AD progression.-
**Prise de fonction**:

- 03/02/2025**Nature du financement**:

- Financement public/privé**Précisions sur le financement**:

- Fondation Vaincre Alzheimer**Présentation établissement et labo d'accueil**:

- Institut de Neurophysiopathologie- The INP is a center of training and research that combines basic and translational research to study the organization, function and interaction of neural cells, as well as the molecular and cellular basis of major brain diseases. The INP is part of the Centre of Excellence in Neurodegeneration (CoEN) and offers an internationally competitive research environment with state-of-the-art facilities. The PhD student will be supervised by Dr. Maud Gratuze. The project will be developed at the Faculty of Medicine, located in the centre of Marseille, a few kilometers from the magnificent seafront, the Calanques National Park and the charm of inland Provence, all ideally suited to outdoor and cultural activities.**Site web**:
**Intitulé du doctorat**:

- Doctorat de neurosciences**Pays d'obtention du doctorat**:

- France**Etablissement délivrant le doctorat**:

- Aix-Marseille Université**Ecole doctorale**:

- Sciences de la vie et de la santé-
- Preferable: comfortable with mouse handling- **SOFT SKILLS **Autonomy, work ethic, critical thinking, adaptability, teamwork, motivation, curiosity, problem-solving- 31/01/2025

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