Engineer Position

il y a 4 jours

Paris, France Institut Imagine Temps plein

**About us**: The _Imagine_ Institute (IHU, ‘Institut Hospitalo-Universitaire’, INSERM U1163) is a recent research structure located within Necker Children’s Hospital (Paris). Its research labs are focused on understanding the molecular mechanisms of genetic diseases that affect the adaptive and innate immune systems, the skeletal dysplasia, the nervous system, stem cell differentiation, kidney physiology, metabolism, etc. **Mission**: **TEAM**: The "Laboratory of Mechanisms and Therapy of Genetic Brain Diseases”, directed by Dr Michela Deleidi at the Imagine Institute in Paris (15) is looking for an engineer. Our team is dedicated to dissecting the molecular mechanisms of genetic brain disorders. We focus on understanding the link between rare genetic diseases and complex age-related disorders. We use human pluripotent stem cell (iPSC) and long-term organoid culture models. Combined with single cell omics, these models help us identify the role of disease-related genetic variants. Our goal is to validate targets with significant diagnostic and therapeutic potential. **ROLE AND RESPONSIBILITIES**: - Maintenance of iPSCs ; - Implementation of neuronal differentiation protocols (2D and 3D) and initial characterization ; - Designing and conducting experiments in molecular biology, cell biology, and biochemistry ; - Implementing imaging techniques (for example, confocal microscopy and live imaging) and electrophysiological recordings (MEA, Multielectrode array) in collaboration with partner teams at the institute ; - Lab management responsibilities including purchasing laboratory reagents, monitoring consumable spending, negotiating with vendors for the purchase of lab equipment and bulk quantity items. **POSITION DETAILS**: - Fixed term contract for 12 months, possibility of extension ; - Salary according to experience. **Profile**: **REQUIREMENTS**: - Strong neuroscience and/or cell biology background ; - Proficiency with molecular and cell biology techniques ; - Prior experience with cell culture; familiarity with iPSC technology and differentiation is a plus ; - The ability to work independently, establish new techniques, interpret and discuss experiments is essential ; - Excellent organizational skills ; - Team-oriented and goal-driven mindset ; - Fluency in scientific English ; - Educational background: Masters or Engineering School. **APPLICATION PROCESS**: - Cover letter ; - Detailed CV with publication list ; - Contact information for two references.

  • Engineer Position

    il y a 1 jour

    Boulevard du Montparnasse, Paris, France Institut Imagine Temps plein

    TEAM :The "Laboratory of Mechanisms and Therapy of Genetic Brain Diseases", directed by Dr Michela Deleidi at the Imagine Institute in Paris (15) is looking for an engineer.Our team is dedicated to dissecting the molecular mechanisms of genetic brain disorders. We focus on understanding the link between rare genetic diseases and complex age-related...

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