Reactivity of Unusual Palladium Zwitterionic

**Reactivity of Unusual Palladium Zwitterionic Complexes**:

- Réf **ABG-125692**
- Stage master 2 / Ingénieur- Durée 6 mois- Salaire net mensuel about 600 or 650 euros a month- 05/09/2024- LSO Ecole Polytechnique- Lieu de travail- Palaiseau Ile-de-France France- Champs scientifiques- Chimie
- Mots clés- Organometallic catalysis, Asymmetric Catalysis, Nitrogen Heterocycles-
- 15/11/2024**Établissement recruteur**:
**Site web**:
The Laboratory of Organic Synthesis (LSO, UMR 7652) is a joint unit between CNRS, Ecole Polytechnique (Palaiseau, France) and ENSTA ParisTech (Palaiseau, France). Our research interests spans from the development of new methodologies, the total synthesis of natural products to the interfaces between organic chemistry and biology.

**Description**:
Due to their ability to engage in both hydrogen-bond donation and acceptance, nitrogen‑containing heterocycles display better interactions with biological targets and therefore are prone to be effective pharmacological agents [1]. In our research group, we focus on the development of original transformations relying on cycloaddition strategies towards the rapid construction of azacycles, and recently turned our attention on palladium-catalyzed cycloadditions involving zwitterionic π‑allylpalladium(II) intermediates [2].-
[1] Njardarson _et al._ _J. Chem. Ed._ **2010**, _87_, 1348. [2] (a) Scuiller, A.; Karnat, A.; Casaretto, N.; Archambeau, A. _Org. Lett._ **2021**, _23_, 2332. (b) Scuiller, A.; Liu, X.; Cordier, M.; Garrec, J. _Synlett_ **2021**, _32_, 981. (c) Scuiller, A.; Casaretto, N.; Archambeau, A. _J. Org. _Chem._ **2023**, _88_, 9941. (d) Roblin, A.; Casaretto, N.; Archambeau, A. _Org. Lett._ **2023**, _25_, 6453. (e) Busicchia, M.; Roblin, A.; Dubois, Carla.; Mekranter, N.; Casaretto, N.; Archambeau, A. _J. Org. Chem._ **2024**, DOI: 10.1021/acs.joc.4c01315.

**Profil**:
The applicant must have a strong background in the field of organic chemistry and knowledge of good laboratory practice.

**Prise de fonction**:

- 01/02/2023