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Postdoc Position
il y a 2 semaines
Institut Necker Enfants Malades (INEM) is a biomedical research center located on the Necker campus. It benefits from numerous state-of-the-art core facilities. The Campus has a long-standing reputation for scientific excellence and key pioneering medical contributions (transplantation, biotherapy, gene therapy). It provides a vibrant environment for basic research and translational innovation.
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**Poste et missions**:
**About the project**
Neurodegenerative and neuroinflammatory diseases are increasingly frequent. They often involve peripheral immune cells that infiltrate the CNS and tissue-resident cells, among which microglia play a prominent role. Microglia can act as drivers of pathogenesis, yet also have crucial beneficial activities in these diseases, controlling the resolution of inflammation and CNS regeneration.
The project capitalizes on a cell-therapy recently developed in the team, which makes use of pure and stable IL-10-producing B cells and cures recipient mice from CNS inflammatory disease within a few days by targeting microglia. These studies will provide a starting point to then address whether the molecular processes identified in microglia are relevant in Human diseases including in multiple sclerosis.
Collectively, these investigations will provide important knowledge to envision the manipulation of microglia to resolve neuroinflammation and promote neuro-regeneration in order to restore health during CNS diseases.
**Mobilité géographique**:
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- The position is funded for 2 years. Salary will be according to experience following INSERM regulation._
