Emplois actuels liés à Analyzing Cell State Transition of Tumor Cells From Tolerant to Sensitive to Cancer Therapeutics, Using Single-cell Data - Sophia Antipolis - Inria
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Sophia Antipolis, France Université Côte d'Azur Temps plein**Distillation pour le traitement par apprentissage profond d'images de microscopie // Distillation for deep learning based processing of microscopy images**: - Réf **ABG-130957** **ADUM-65136** - Sujet de Thèse - 12/04/2025 - Université Côte d'Azur - Lieu de travail- Sophia Antipolis Cedex - France - Intitulé du sujet- Distillation pour le traitement...
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15 Phd Positions in The Field of Respiratory Research
il y a 2 jours
Sophia Antipolis, France Centre Nationale de la Recherche Scientifique Temps plein**15 PhD positions in the field of respiratory research - RESPIRE-EXCEL Doctoral Network**: - Réf **ABG-128811** - Sujet de Thèse - 21/02/2025 - Financement de l'Union européenne - Centre Nationale de la Recherche Scientifique - Lieu de travail- Valbonne Sophia-Antipolis - Provence-Alpes-Côte d'Azur - France - Intitulé du sujet- 15 PhD positions in the...
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Phd Position F/m Compiling Dynamic Languages to
il y a 2 semaines
Sophia Antipolis, France Inria Temps pleinLe descriptif de l’offre ci-dessous est en Anglais_ **Type de contrat **:CDD **Niveau de diplôme exigé **:Bac + 5 ou équivalent **Autre diplôme apprécié **:Master thesis **Fonction **:Doctorant **A propos du centre ou de la direction fonctionnelle**: The Inria centre at Université Côte d'Azur includes 37 research teams and 8 support services....
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[doct2024-cronos] Koopman Analysis of Brain Signals
il y a 7 jours
Sophia Antipolis, France Inria Temps pleinLe descriptif de l’offre ci-dessous est en Anglais_ **Niveau de diplôme exigé **:Bac + 5 ou équivalent **Fonction **:Chercheur contractuel **A propos du centre ou de la direction fonctionnelle**: The Inria centre at Université Côte d'Azur includes 37 research teams and 8 support services. The centre's staff (about 500 people) is made up of...
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Graduate Physical Design Engineer
il y a 3 jours
Sophia Antipolis, France Arm Temps pleinShow more **Job Overview**: We are the Silicon Enablement Implementation team, part of the Arm Physical Design Group. This diverse, engineering-centric group invents, defines and develops innovative physical implementation methods for CPU/GPU class designs using optimized physical IP. We pursue next-generation Arm CPUs and GPUs, inventing new concepts that...
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Digital Hardware Design for Test Engineer
il y a 1 semaine
Sophia Antipolis, France NXP Semiconductors Temps plein**Business Unit Description/Business Line Description/ Local team description**: In the MCU-MPU Engineering organization, the System-On-Chip team based in Sophia Antipolis is in charge of the i.MX product family development. We are looking for a senior design for test digital hardware engineer. In this exciting role, you will be challenged by taking your...
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Postdoc Toxicologue Recherche Ngra
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Postdoctoral Research Scientist
il y a 1 semaine
Sophia Antipolis, France Bayer Temps plein**At Bayer we’re visionaries, driven to solve the world’s toughest challenges and striving for a world where, Health for all, Hunger for none’ is no longer a dream, but a real possibility. We’re doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our...
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Postdoctoral Research Scientist
il y a 3 jours
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Cpu Physical Implementation Engineer
il y a 2 semaines
Sophia Antipolis, France Arm Temps pleinShow more **Job Overview**: Do you want to help Arm and its partners to build outstanding products? Arm’s Sophia Antipolis design centre is located in one of the most appealing parts of France, at the heart of Europe’s largest and most dynamic technology park. Surrounded by mountains and the Mediterranean Sea, this exceptional design center has...
Analyzing Cell State Transition of Tumor Cells From Tolerant to Sensitive to Cancer Therapeutics, Using Single-cell Data
il y a 2 semaines
_Le descriptif de l’offre ci-dessous est en Anglais_ **Type de contrat**: CDD **Niveau de diplôme exigé**: Bac + 5 ou équivalent **Fonction**: Ingénieur scientifique contractuel **Niveau d'expérience souhaité**: Jeune diplômé **A propos du centre ou de la direction fonctionnelle**: The Inria center at Université Côte d'Azur includes 42 research teams and 9 support services. The center’s staff (about 500 people) is made up of scientists of different nationalities, engineers, technicians and administrative staff. The teams are mainly located on the university campuses of Sophia Antipolis and Nice as well as Montpellier, in close collaboration with research and higher education laboratories and establishments (Université Côte d'Azur, CNRS, INRAE, INSERM...), but also with the regional economic players. With a presence in the fields of computational neuroscience and biology, data science and modeling, software engineering and certification, as well as collaborative robotics, the Inria Centre at Université Côte d'Azur is a major player in terms of scientific excellence through its results and collaborations at both European and international levels. **Contexte et atouts du poste**: The molecular mechanisms involved in tumor cell tolerance to immune cell killing or to cancer therapeutics contribute to the partial treatment efficacy and therefore represent potential targets for combination treatments. Identifying these molecular mechanisms is an essential task in the rational design of efficacious drug combinations. It has been shown that drug-tolerant cells can emerge from transient differences in cellular contexts and we have established an approach to profile single-cell tolerance of non-genetic origins [1]. At the modeling level, we developed an approach to detect cellular mechanisms responsible for the amplification of transient and small differences, that ultimately lead to significant differences in single-cell signatures and dynamic response of sensitive or tolerant phenotypes [2]. The objective of this short project is to study and understand the cell state transition of tumor cells between sensitive and tolerant modes, by the analysis of RNAseq data as well as a set of kinetic parameters associated to a mathematical model. This work is funded by a collaborative project between M. Chaves at MACBES team at Inria Center of Université Côte d'Azur and J. Roux single-cell biology lab at the Institut de Pharmacologie Moleculaire et Cellulaire, CNRS. **Mission confiée**: The first task is this project to use diffusion maps to analyze RNAseq data (see, for example, the R-package Destiny [3]). This will give us a landscape of genetic signatures covering both sensitive and tolerant cells, and we will investigate the adaptation of cells to a drug or an immune effector by detecting "pseudo-trajectories" between the two phenotypes. The second task is to similarly analyse a set of kinetic parameters obtained from the mathematical models previously developed in our team. These models provide a set of parameters for each cell, which serve as a first distinction between sensitive and tolerant cell states. Here, we will look for features that separate the two groups in the parameter space. Finally, we will systematize a method for comparison of the RNAseq data and kinetic parameter analysis and establish a link between genomic data and kinetic parameters. References: [1] Mickael Meyer, Agnès Paquet, Marie-Jeanne Arguel, Ludovic Peyre, Luis C. Gomes-Pereira, Kevin Lebrigand, Baharia Mograbi, Patrick Brest, Rainer Waldmann, Pascal Barbry, Paul Hofman, Jérémie Roux, Profiling the Non-genetic Origins of Cancer Drug Resistance with a Single-Cell Functional Genomics Approach Using Predictive Cell Dynamics, Cell Systems, 11(4), 367-374.e5 (2020). [2] Chaves, M., Gomes-Pereira, L.C., and Roux, J. Two-level modeling approach to identify the regulatory dynamics capturing drug response heterogeneity in single-cells. Sci Rep 11, 20809 (2021). [3] Angerer P, Haghverdi L, Büttner M, Theis FJ, Marr C & Buettner F (2016) Destiny: Diffusion maps for large-scale single-cell data in R. Bioinforma Oxf Engl 32: 1241-1243 **Principales activités**: 2. Numerical simulations and analysis of the results. 3. Writing a report on the project. **Compétences**: **Avantages**: - Subsidized meals - Partial reimbursement of public transport costs - Leave: 7 weeks of annual leave + 10 extra days off due to RTT (statutory reduction in working hours) + possibility of exceptional leave (sick children, moving home, etc.) - Possibility of teleworking (after 6 months of employment) and flexible organization of working hours - Professional equipment available (videoconferencing, loan of computer equipment, etc.) - Social, cultural and sports events and activities - Access to vocational training **Rémunération**: From 2692 € gross monthly (according to degree and experience). **Informations générales**: - **Thème/Domaine**: Modélisation et comm
