Researcher Position in Organic Chemistry

il y a 2 semaines

Talence, France Université de Bordeaux - ISM Temps plein

**Researcher Position in Organic Chemistry**

Synthesis of AI-Designed Antimicrobial Ultrashort Peptides

**Institution**: Institut des Sciences Moléculaires (Team ORGA), Université de Bordeaux, Talence, France

**Application Deadline** : October 1st, 2025

**Project**: To fight antibiotic resistance observed in oral and dental pathologies remains a major public health concern worldwide. In response to this challenge, research is exploring new strategies to limit the proliferation of _S. mutans_ which plays a central role and is also involved in serious extra-oral infections such as certain heart diseases. Our project aims to develop novel AI-generated ultra-short antimicrobial peptides and analogues with fluorescent and/or polyamines moieties, effective against _S. mutans_. Machine learning models will help optimizing the selection and design of more effective peptides. The combination of activity tests with imaging methods will provide valuable insights into their antimicrobial efficiency and interactions with _S. mutans_. The results of this project will open new perspectives for the prevention and treatment of severe dental diseases.

**Key Responsibilities** : Design and carry out multi-step organic synthesis to develop novel ultra-short peptides and derivatives with antimicrobial properties. Analyze and characterize products using various spectroscopic and analytical techniques (e.g., NMR, MS, UV-Vis, fluorescence). Collaborate with interdisciplinary teams to advance shared research goals. Supervise and mentor graduate and undergraduate students within the laboratory.

**Salary**: The gross monthly salary starts at €2,800.00 (with a PhD degree) and at €2,300.00 (with a Master degree), depending on qualifications and experience.

**How to Apply**: Send to : cover letter, CV (2 pages max) including references, list of publications, 4 pages summary of previous research experience.
- **This research position is funded by Bordeaux University (interdisciplinary and exploratory research program) for at least a 12-months duration.**_

Type d'emploi : CDD
Statut : Cadre
Durée du contrat : 12 mois

Rémunération : à partir de 2 800,00€ par mois

Lieu du poste : En présentiel

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