In Vitro Study Manager Preclinical Immuno-oncology

**In vitro Study Manager Preclinical Immuno-Oncology**

**Job offer #**:SM1025**

**Type**: Full time position, permanent or fixed-term contract

**Location**:Bordeaux, France

**Are you an experienced research associate passionate about immuno-oncology? Do you have proven expertise in immune cell isolation, culture/co-culture, and multiparametric flow cytometry? Have you contributed to innovative research programs in cancer immunotherapy, driving the setup, execution, and analysis of in vitro/ex vivo experimentations? If so, we want to hear from you**

**About us**

**Explicyte is a preclinical and translational contract research organization specialized in immuno-oncology.**Our goal is to assist academics, biotechs and pharmas in the discovery of novel targets and novel cancer immunotherapies.

**With a team of 25 experts, we’re a human-sized company**, which brings under the same roof cell biologists, immunologists, _in vivo _scientists, medical oncologists and bioinformaticians. **Focused on Sponsors’ projects**, our activity also involves in-house R&D and external collaborations, which have led to the publication of **30+ papers in high impact-factor journals.**

**Based in Bordeaux, our lab is located at the Bergonié Comprehensive Cancer Center**, where we work in close contact with medical oncology teams. We believe **Explicyte is a place to learn, grow, and have impact in the fight against cancer.**

**The position**

Within our **in vitro team**, you will primarily support **a major innovative Sponsor’s research program** while contributing to other internal initiatives. You will be responsible for **executing** **in vitro / ex-vivo experiments** with autonomy and rigor, ensuring timely capture, analysis, and reporting of data.

You will interact closely with all team members, including Study Directors, and will report directly to the CSO.

**Your skills & traits**
- **Ph.D. or Master’s degree**in cell biology, immuno-oncology, biotechnology, pharmacology, or related fields
- **Minimum 3/4-year experience**in biotechnology, pharma, CRO, or academic research, ideally in oncology/immuno-oncology
- **Solid knowledge**of tumor immunology and cancer therapies
- **Expertise**in immune cell isolation, culture / co-culture, and immune phenotyping
- Expertise in **multiparametric flow cytometry**and functional immune cell-based assays
- **Skilled in data acquisition, analysis, and visualization tools**(FlowJo, Incucyte, GraphPad Prism)
- **Strong record in project management**, with proven ability to plan, execute, and document experiments autonomously and meticulously
- **Excellent organizational, interpersonal, and communication skills**
- **Experience with 3D cultures (spheroids, organoids) is a plus**
- **Proficient in written scientific English**(reading protocols, writing reports)

**Your missions & responsibilities**
- **Implement and manage studies**autonomously, ensuring rigorous and timely execution according to schedules
- **Draft protocols**based on proposed scientific and experimental strategies
- **Design & execute experimental workflows**, including plate setup, treatment conditions, and dose-response functions
- **Perform functional in vitro immuno-oncology assays**, including pharmacological and gene-editing approaches
- **Isolate, culture/co-culture, and characterize immune cells**for functional immuno-oncology assays
- **Maintain, characterize, and validate tumor cell lines**
- **Collect and process samples**, including cells and supernatants, for downstream analyses
- **Prepare samples for omics analyses**, including RNA-seq and proteomics
- **Design and perform multiparametric flow cytometry panels**for immune phenotyping, cytotoxicity, and T cell activation analyses
- **Capture, analyze, and compile cytokine responses**(LEGENDplex, flow cytometry)
- **Capture and analyze live-cell imaging kinetics**and compile experimental data
- **Ensure high-quality data capture, accuracy, and completeness of study documentation**
- **Deliver analyzed data**in accordance with study requirements
- **Contribute to experimental development**by implementing method improvements

Looking for an opportunity to work on cutting-edge immuno-oncology projects, in an environment that values rigor, scientific excellence, and offers professional growth in a dynamic, human-sized organization?

Type d'emploi : Temps plein, CDI, CDD
Statut : Cadre

Rémunération : 30 000,00€ à 55 000,00€ par an

Avantages:

- Crèche d'entreprise
- Prise en charge du transport quotidien

Lieu du poste : En présentiel