Senior Scientist

At
Orakl Oncology
, we are accelerating the development of oncology treatments. Today, fewer than 5% of new cancer drugs succeed in clinical trials. Clearly, new methods are needed. We combine
cutting-edge biology
and
AI
to build the next generation of insight platforms with the world's largest cohort of patient tumor avatars. These avatars fuel our
AI-powered predictive engine
, helping to anticipate clinical trial outcomes, validate therapies, and uncover new drug candidates.

Our mission is simple yet ambitious: to
bring more effective treatments to patients
who need them - and to make drug development smarter, faster, and more personalized. We collaborate with top hospitals, research institutes, and pharmaceutical companies worldwide. Backed by leading investors, we are a
fast-growing, mission-driven startup
at the intersection of science and technology.

We are looking for a
passionate and dynamic scientist
to build the tools that will fuel Orakl's drug development efforts. Your role will be to design, build and optimize new screening methods around organoid culture. You will drive high-impact discovery efforts by designing and managing the execution of critical in-house experiments, establishing external collaborations with key vendors, and ensuring high-quality data generation.

Must have

• PhD in molecular biology, cancer biology, biotechnology, or related field, ~1–5 years postdoctoral or industry experience would be a plus.
• Strong, hands-on expertise in 3D cell culture and patient-derived organoids.
• Prior experience in drug screening, and preferably high-throughput screening.
• Proven proficiency with CRISPR gene editing in mammalian systems (ideally organoids): gRNA design, engineering, optimization, troubleshooting.
• Exceptional wet-lab fundamentals: sterile technique, routine culture, molecular biology, cloning, assay development, QC.
• Demonstrated ability to independently plan, prioritize, and execute complex experimental pipelines with high quality and reproducibility.
• Strong analytical, quantitative data interpretation, and clear documentation/reporting skills.

Nice to have

• Direct background in oncology research.
• Experience with pooled/arrayed CRISPR screens or other functional genomics approaches.
• Experience with drug-response profiling in organoids (dose–response, time-course, combination assays).
• Previous responsibility for managing CROs or academic collaborations.
• Experience mentoring junior scientists, lab technicians and/or establishing lab standards.
• Prior involvement in early-stage drug discovery or cross-functional oncology research.

HR Call (15 minutes call)
– An initial discussion to better understand your background, experiences, and motivations.

Technical Interview (45 minutes call)
– A deep dive into your technical skills and expertise relevant to the role.

Engineering Case (60-minutes presentation + discussion) -
You will be presenting a piece of work you have previously worked on and which you are proud of. This will be in front of the relevant members of the Orakl Oncology team. If possible this can be done in person.

Founder Interview:
As final step of our recruitment process, you will meet the founders of Orakl Oncology in person at our office. This meeting is an opportunity for the founders to assess cultural fit and ensure alignment with our company values.