Senior Laboratory Technician/Engineer

Senior Laboratory Technician/Engineer – Early CMC / Lead Identification

We are an innovative biotech company specializing in the development of next-generation therapeutics (single-domain antibodies, conjugates, siRNA, etc.). Our agile and passionate R&D team works on cutting-edge projects in immunology, oncology, and rare diseases.

Job Summary

We are seeking a highly motivated Senior Laboratory Technician to join our Early CMC / Lead Identification team. The ideal candidate is an experienced cell biologist with hands-on expertise in cellular binding assays (FACS), internalization identification, RNA extraction, RT-qPCR, and cell culture. This role is central to the early qualification of therapeutic candidates and requires strong experimental rigor, autonomy, and the ability to work collaboratively in a dynamic biotech environment. The role reports directly to the
Director, Early CMC.

Work location : Paris (15ème)

Full-time permanent contract

Keys responsabilities :

Cell-based Assays & Lead Characterization:

• Perform cellular binding assays by flow cytometry (FACS) to characterize candidate molecules.
• Design and execute internalization assays (microscopy, FACS-based internalization, etc.).
• Prepare and maintain cell lines needed for screening and characterization.

Molecular & Cellular Biology

• Perform RNA extraction, reverse transcription, and RT-qPCR for gene expression profiling and target quantification.
• Perform protein extraction and Western Blots for protein levels quantification.
• Quantitatively analyze internalization or signaling markers from cell-based experiments.

Cell Culture & Model Development

• Culture, expand, and bank a variety of cell lines (adherent and suspension).
• Validate cellular models for target expression (flow cytometry, RT-qPCR).

Data Collection, Analysis & Reporting

• Ensure rigorous data recording following internal quality standards (ELN, SOPs).
• Analyze and interpret experimental results; present data to project teams.
• Contribute to troubleshooting and optimization of experimental workflows.

Cross-functional Collaboration

• Work closely with Antibody Discovery, Chemistry, and CMC teams to support pipeline progression.
• Participate in the development of early CMC packages (binding, internalization, expression analysis).

Qualifications & Experience required

• Bachelor or Master's degree (BTS, DUT, Licence, Master, or equivalent) in Cell Biology, Molecular Biology, Biotechnology, or a related field.
• ≥7-10 years of laboratory experience in biotech, pharma, or academic research (industry experience preferred).
• Familiarity with early CMC workflows and lead evaluation is a plus.
• Hands-on experience with flow cytometry (FACS) for cellular binding assays is required.
• Strong experience with RNA extraction, RT-qPCR, and quantitative data analysis.
• Expertise in cell culture and good aseptic technique.
• Experience performing internalization assays or related cellular uptake studies.
• Excellent organizational skills, autonomy, and ability to manage multiple experiments in parallel.
• Strong analytical mindset, attention to detail, and rigorous documentation.
• Ability to work effectively in a multidisciplinary, fast-paced environment.

Our Values :

• Scientific curiosity
  : Ability to explore complex topics with a proactive, solution-oriented mindset and strong problem-solving skills.
• Rigor and analytical mindset
  : Methodical approach, critical thinking when interpreting experimental data, with strong attention to detail and reproducibility.
• Team spirit:
  Close collaboration with R&D teams, respect for complementary expertise, and clear, constructive communication.
• Scientific integrity:
  Adherence to protocols, transparency in results, and a strong ethical commitment throughout the project.
• Adaptability
  : Agility in a fast-evolving environment, ability to handle unexpected challenges, and continuous learning from both successes and failures.
• Passionate
  about translating science into impact for patients

Why join us?

• Salary: 40K – 45K depending on profile
• Annual individual performance bonus
• 100% coverage of Vélib bike subscription
• 60% coverage of family health insurance plan
• Exciting, high-impact scientific projects
• Supportive and dynamic work environment
• Small, agile team with real responsibilities from day one
• Modern offices, state-of-the-art equipment… and unlimited coffee