Biochemistry Research Associate- Structural Biology

il y a 2 jours

Toulouse, Occitanie, France Pierre Fabre Laboratories Temps plein

Pierre Fabre is seeking a talented and highly motivated
Biochemistry Research Associate
to join our Oncology Drug Discovery team and support our small molecule/antibody identification and characterization efforts.

The ideal candidate will have relevant experience in the pharmaceutical/biotech industry, with sound hands-on expertise conducting high-resolution structural analysis of biological macromolecules with state-of-the-art bioinformatics, protein biochemistry, biophysics and structural biology techniques.

This position is a lab-based and attached to our Oncopôle site in Toulouse, France.

Your role within a pioneering company in full expansion:

Key Responsibilities:

  • Propose experimental strategies to enable structural characterization studies of proteins and their interactions with physio-pathologically relevant ligands, as well as with small and large molecular weight drug candidates.

  • Design relevant protein constructs and corresponding vectors for heterologous recombinant protein expression in bacteria, insect- and mammalian cell hosts.

  • Prepare biological samples for subsequent structural characterization studies, including isotope labelling, purification crystallization trials and grid clipping.

  • Coordinate sample transfer and remotely supervise structural analysis at partner laboratories.

  • Analyze and process structural data to generate accurate models.

  • Ensure high-quality data generation, analysis, and timely report to project teams.

  • Leverage lab automation to improve assay operation, quality, and overall productivity.

  • Properly document experimental design, findings, and protocols and comply with all laboratory training and safety requirements.

  • Collaborate with multi-disciplinary project teams and communicate scientific/technical contributions to deliver on project goals in relevant meetings.

  • Establish relationships and coordinate collaborations with vendors, external partners and CROs to achieve high standards of productivity and quality, extend internal capabilities and optimally serve project needs.

  • Drive scientific and technical innovations to develop and enhance functional capabilities.

We offer an attractive remuneration/benefits package: Incentives, profit-sharing, Pierre Fabre shareholding with matching contribution, health and provident insurance, 16 days of holidays (RTT) in addition to 25 days of personal holidays, public transport participation, very attractive CE...

Your skills at the service of innovative projects:

Qualifications, Experience and Skills:

  • Ph.D. in Biochemistry, Biophysics or related field, with significant exposure to drug discovery (or MSc with 5+ years' relevant experience in a biotech/pharmaceutical setting).
  • Demonstrated hands-on proficiency in several high-resolution structural biology methods (e.g. X-ray crystallography, NMR,…)
  • Working knowledge of techniques for the characterization of protein-protein and protein-ligand interactions (e.g. thermal unfolding/denaturation, light scattering, analytical ultracentrifugation, structural MS).
  • Proficiency with relevant data processing analysis and visualization software tools.
  • Expertise with mechanistic enzymology and/or molecular pharmacology are highly desired.
  • Experience in oncology is a plus.
  • Motivated and agile team player with the ability to work in a collaborative environment across the R&D organization.
  • Excellent verbal, and written communication skills in English are essential.

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