Post-Doctoral Research Visit F/M Individual-based modeling of coupled single-cell and population processes
il y a 3 jours
Contexte et atouts du poste
Inria is the French national institute for research in computer science, control, and applied mathematics promoting scientific excellence and technology transfer. The research topics of pour group are at the intersection of mathematical biology, statistics, control engineering, and statistical physics applied to problems in biology.
Mission confiée
This research project aims to better understand the mechanisms related to gene expression and plasmid
copy number fluctuations in a cell population with application to synthetic biology.
Modelling gene expression has been the subject of much interest in the literature. The models proposed are generally single-cell, and based on the central dogma of molecular biology, which describes a simplified scheme whereby instructions on DNA are transcribed into messenger RNA, which in turn is translated into proteins. In this scale, the environment is often assumed to be highly invariant and the number of molecules for each protein is small and therefore subject to considerable stochasticity. These numbers of molecules are modelled using continuous-time Markov chains (CTMC). In the scale of the demography, this individual dynamics becomes rapid and can be approximated by continuous models like ODEs. In addition, it becomes essential to take into account the unequal sharing of all this molecular content at the time of cell division. This mechanism is well known to enhance the heterogeneity of gene expression at the population level. How to develop models that capture all these aspects while remaining analytically or numerically tractable is an open research question and will be the focus of this project.
Principales activités
Develop an individual-based modeling framework that can be used to understand coupled single-cell and population processes. Develop approaches to mathematically analyse individual-based models and to numerically simulate them. Make use of single-cell microscopy data of our collaborators to parameterize a model of a synthetic gene circuit in bacteria. Use the model to study how the burden for cells created by the synthetic gene circuit affects emerging population growth rates.
Compétences
Strong programming and mathematics skills. Prior experience with single-cell microscopy data. Prior experience with stochastic individual-based models.
Avantages
Subsidized meals Partial reimbursement of public transport costs Leave: 7 weeks of annual leave + 10 extra days off due to RTT (statutory reduction in working hours) + possibility of exceptional leave (sick children, moving home, etc.) Possibility of teleworking and flexible organization of working hours Professional equipment available (videoconferencing, loan of computer equipment, etc.) Social, cultural and sports events and activities Access to vocational training Social security coverage
Rémunération
According to profile
-
Palaiseau, France INRIA Temps pleinContexte et atouts du poste Inria is the French national institute for research in computer science, control, and applied mathematics promoting scientific excellence and technology transfer. The research topics of pour group are at the intersection of mathematical biology, statistics, control engineering, and statistical physics applied to problems in...
-
Postdoctoral Researcher
il y a 4 semaines
Palaiseau, France ONERA Temps plein**Title : Data analysis on aluminum combustion in a solid-propellant flame** **Keywords** Rocket propulsion, solid propulsion, aluminum, combustion modeling, CFD, data analysis, laser diagnostics, laser-induced fluorescence imaging **Profile and skills required** A PhD degree in fluid dynamics and combustion or an associated field Knowledge in numerical...
-
Single-Photon Source Research Engineer
il y a 2 semaines
Palaiseau, Île-de-France Quandela Temps pleinQuandela is a leader in the development and commercialization of quantum computers based on the manipulation of single photons. We are seeking a full-time (permanent contract) Research Engineer to participate in the optimization of Quandela's single-photon sources. We work with quantum dots in micropillar cavities and you will join the research team...
-
Single-Photon Source Research Engineer
il y a 4 semaines
Palaiseau, France Quandela Temps pleinQuandela is a leader in the development and commercialization of quantum computers based on the manipulation of single photons. We are seeking a full-time (permanent contract) Research Engineer to participate in the optimization of Quandela's single-photon sources. We work with quantum dots in micropillar cavities and you will join the research team...
-
Palaiseau, France INRIA Temps pleinContexte et atouts du poste As part of a national project on quantum computing, the aim is to develop a model for quantum computing, using graphical and categorical structures in particular. Travel is financed by the project. Mission confiée Assignments : With the help of Renaud Vilmard and Vladimir Zamdzhiev, the recruited person will be...
-
Palaiseau, France INRIA Temps pleinContexte et atouts du poste While artificial intelligence is growing at a fast pace, the bulk of the world’s computing power remains targeted at modeling and predicting physical phenomena, such as climate models, weather forecasting, or nuclear physics. These simulations are run on highly parallel supercomputers on which both the hardware and the...
-
Single-Photon Source Fabrication Engineer
il y a 4 semaines
Palaiseau, France Quandela Temps pleinQuandela is a leader in the development and commercialization of quantum computers based on the manipulation of single photons. We are seeking a full-time (permanent contract) Fabrication Engineer to participate in the optimization of Quandela's single-photon sources. We work with quantum dots in micropillar cavities and you will join the research team...
-
Cdd - Engineer in Techno-economic Analysis and
il y a 3 semaines
Palaiseau, France TotalEnergies Temps plein**Pays** France **Lieu** 91 - Essonne **Lieu de travail** PALAISEAU-ROUTE DE SACLAY(FRA) **Domaine** Recherche Innovation&Développt, Stratégie Economie Business **Type de contrat** CDD **Expérience** Minimum 3 ans - You have an engineering or doctoral training in the field of renewable energies or physics/chemistry. You have knowledge of...
-
Post-doctoral Research Visit F/m Bridging The Gap
il y a 1 semaine
Palaiseau, France Inria Temps pleinLe descriptif de l’offre ci-dessous est en Anglais_ **Type de contrat **:CDD **Contrat renouvelable **:Oui **Niveau de diplôme exigé **:Thèse ou équivalent **Fonction **:Post-Doctorant **Niveau d'expérience souhaité **:Jeune diplômé **Contexte et atouts du poste**: Every year Inria International Relations Department has a few postdoctoral...
-
Post-doctoral Research Visit F/m Adapting Deep
il y a 2 semaines
Palaiseau, France Inria Temps pleinLe descriptif de l’offre ci-dessous est en Anglais_ **Type de contrat **:CDD **Contrat renouvelable **:Oui **Niveau de diplôme exigé **:Thèse ou équivalent **Fonction **:Post-Doctorant **A propos du centre ou de la direction fonctionnelle**: - The Inria Saclay-Île-de-France Research Centre was established in 2008. It has developed as part of the...
-
Palaiseau, France CEA Temps pleinPosition description Category Mathematics, information, scientific, software Contract Fixed-term contract Job title Research Engineer in Model-Based Engineering for Security Assurance of Medical Devices H/F Socio-professional category Executive Contract duration (months) 24 Job description Advances in healthcare...
-
Palaiseau, France CEA Temps pleinPosition description Category Mathematics, information, scientific, software Contract Fixed-term contract Job title Research Engineer in Model-Based Engineering for Security Assurance of Medical Devices H/F Socio-professional category Executive Contract duration (months) 24 Job description Advances in healthcare...
-
Single-Photon Source Fabrication Engineer
Il y a 2 mois
Palaiseau, France Quandela Temps pleinQuandela is a leader in the development and commercialization of quantum computers based on the manipulation of single photons. We are seeking a full-time (permanent contract) Fabrication Engineer to participate in the optimization of Quandela's single-photon sources. We work with quantum dots in micropillar cavities and you will join the research team...
-
Palaiseau, France INRIA Temps pleinContexte et atouts du poste Every year Inria International Relations Department has a few postdoctoral positions in order to support Inria international collaborations. The postdoctoral contract will have a duration of 12 to 24 months. The default start date is November 1st, 2024 and not later than January 1st, 2025. The postdoctoral fellow will be...
-
Palaiseau, France INRIA Temps pleinContexte et atouts du poste Every year Inria International Relations Department has a few postdoctoral positions in order to support Inria international collaborations. The postdoctoral contract will have a duration of 12 to 24 months. The default start date is November 1st, 2024 and not later than January 1st, 2025. The postdoctoral fellow will be...
-
Palaiseau, Île-de-France INRIA Temps pleinContexte et atouts du poste Every year Inria International Relations Department has a few postdoctoral positions in order to support Inria international collaborations. The postdoctoral contract will have a duration of 12 to 24 months. The default start date is November 1st, 2024 and not later than January 1st, 2025. The postdoctoral fellow will be...
-
24-097 Integration of Thermal Imaging and Radar for
il y a 2 semaines
Palaiseau, France CNES - Centre National d'Etudes Spatiales Temps pleinDoctorat, 36 mois - Temps plein - Aucune expérience exigée - Maitrise, IEP, IUP, Bac+4 - Digital technologies for remote sensing **Mission**: This doctoral project is part of the Onera "MUSIC" research chair, led by Elise Colin, which focuses on developing innovative image processing and AI techniques for unconventional data. It explores the...
-
Post-doctoral Research Visit F/m Bridging The Gap
il y a 2 semaines
Palaiseau, Île-de-France Inria Temps pleinLe descriptif de l'offre ci-dessous est en Anglais_Type de contrat :CDDContrat renouvelable :OuiNiveau de diplôme exigé :Thèse ou équivalentFonction :Post-DoctorantNiveau d'expérience souhaité :Jeune diplôméContexte et atouts du poste:Every year Inria International Relations Department has a few postdoctoral positions in order to support...
-
Post-doc Application of Formal Methods for
il y a 2 semaines
Palaiseau, France CEA Temps pleinPosition description **Category**: - Electronics components and equipments **Contract**: - Fixed-term contract **Job title**: **Socio-professional category**: - Executive **Contract duration (months)**: - 18 **Job description**: - Your main missions will be: - To propose and develop a formal modeling strategy for the temporal behavior of the...
-
Fiber Pigtailing Engineer
Il y a 3 mois
Palaiseau, France Quandela Temps pleinDescriptionQuandela is a leading company in the development and commercialization of quantum computing solutions based on the manipulation of single photons. We are seeking a full-time (permanent contract - CDI) Single Photon Source Fiber Pigtailing Engineer to participate in the development of Quandela's quantum light emitter devices together with the large...
