Senior scientist in in vitro Pharmacokinetics

il y a 3 semaines

GifsurYvette, France Servier Temps plein

Founded to serve health, Servier is an international pharmaceutical group governed by a Foundation, which aspires to have a significant societal impact for patients and for a sustainable world. Its unique governance model enables it to fully serve its vocation with a long-term vision: to be committed to therapeutic progress for the benefit of patients. The 21,800 employees who make up the Group are committed to this common vocation, a source of inspiration on a daily basis. As the world leader in cardiology, Servier's ambition is to become a recognised, focused and innovative player in oncology by targeting difficult-to-treat cancers. This is why the Group devotes more than 50% of its R&D budget to the development of targeted and innovative oncology therapies. Neurosciences and immuno-inflammatory diseases represent a future growth driver. In these areas, Servier focuses on a limited number of specific diseases in which a precise characterisation of the patients makes it possible to propose a targeted therapeutic response, thanks to precision medicine. To promote access to quality healthcare for all, and at a lower cost, the Group also offers a range of generic medicines covering the majority of diseases, based on strong brands in France, Eastern Europe, Brazil and Nigeria. In all these areas, the Group integrates the patient's voice at every stage of the drug life cycle. Headquartered in France, Servier has a strong geographic presence in more than 150 countries and generated sales of €4.7 billion in 2021.
www.servier.com

We are seeking a Senior scientist to join the Drug Interaction and In vitro Technology team in Saclay, within the Drug Metabolism and Pharmacokinetics Department (DMPK). DMPK department is part of the Translational Medicine organization of Servier R&D located at the Servier Paris Saclay Research&Development Institute. The DMPK unit plays a major role in the research and development strategy for new drugs via i. Supporting the early optimization and selection of drug candidates, ii. Accelerating entry into clinical phase I, iii. Providing DMPK knowledge at all stages of drug candidate development. The DIIVT team aims to predict the DMPK and DDI profile of new drug candidates, from the early stages of drug discovery to the post-marketing phase.

Missions:

Plan the studies to be carried out in coordination with the subject matter experts and/or the representatives of the discipline Organize the means necessary for the successful completion of the study in a timely manner To conduct in vitro experiments (with non-radiolabelled or radiolabelled drugs) aimed at predicting the risks of drug interactions and the pharmacokinetics of candidates (even the safety profile) and using cellular and subcellular models specific to these activities Carry out the studies according to the protocol / study plan and the operating procedures (SOP) in force Manage the electronic laboratory notebooks in which are recorded with the required precision, the raw data in accordance with the SOPs in force Report the results of the study. Communicate to the representatives of the discipline and/or the managers and/or subject matter experts the results obtained during the course of the studies, as well as raise the alerts having an impact on their progress (completion time, cost, modification) Document deviations from the protocol / study plan and operating methods and inform the study director Scientific, technical and regulatory monitoring (Bibliography, Congress etc.). Implement new tools and/or technologies to extend the capabilities and improve the efficiency of in vitro predictions of pharmacokinetics and drug-drug interactions. Update in a regular manner the operating procedures (SOP) according to the right level of quality defined and the technico-scientific knowledge Be responsible for monitoring the maintenance of certain devices Take charge of several projects and collaborate cross-functionally with colleagues in the department and from other Poles of Activity of the Saclay Research Institute

Profile:

Pharmacist, PhD, Engineer or Master The candidate should possibly have a minimum of 3 years of experience in in vitro assays for drug development in the field of DMPK.  Practical experiences of cellular and/or subcellular in vitro techniques (culture, incubation, enzymatic assay, biochemical assay) specific to studies aimed at predicting the risks of drug interactions and pharmacokinetics of candidates (or even safety profile). A practical skill on laboratory automate would be considered as a plus. Practical or theoretical experiences of H/UPLC assay techniques coupled with mass spectrometry, or fluorescence, ultraviolet, luminescence detection…. A Practical experience in cell imaging and a mastery in labelling technique (immunofluorescence) and use of imaging instruments (scan array) would be considered as a plus. Theoretical knowledge or training and experience in pharmacokinetics interpretation and drug interaction predictions as well as theoretical knowledge of the pharmacokinetics area, i.e. metabolic enzymes, drug transporters and their regulatory proteins, enzymology, cell biology and analytical chemistry ( H/UPLC coupled with mass spectrometry). Proficiency in computer office tools (XLS, Word) and analysis software (MassLynx) Fluent English  Rigor, well organized, autonomy, multi-skills, reactivity, good written and oral communication skills, team spirit, proactivity, able to work in a complex fast-changing environment, prone to innovation. 

Whatever your area of expertise, your work within the Servier Group helps advance therapeutic progress for the benefit of patients. You will be part of teams recognized for their scientific excellence and reach your full potential in a professional environment that encourages you to develop yourself. Tailor-made onboarding journeys, mobility opportunities, quality trainings, responsible management, team spirit... All this and more in a workplace focused on your well-being.

At Servier, we are committed to therapeutic progress to serve patient needs. We put the diversity of our employees as a source of richness for the fulfillment of this vocation.

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