![ESRF](https://media.trabajo.org/img/noimg.jpg)
PhD Thesis Student
il y a 5 jours
Context & Job description
Thesis subject: Exotoxin A from Pseudomonas aeruginosa at MASSIF-1: fragment screening in the era of Artificial Intelligence
Pseudomonas aeruginosa is human pathogen which has been classified by the World Health Organisation as one of the three highest priority antibiotic-resistant bacterias. It is one of the leading causes of hospital-acquired-infections and was responsible for more than half a million deaths in 2019. Central to its virulence exotoxin A protein, which inactivates the host cell translational machinery leading to cell death. In this Ph.D., the successful candidate will identify compounds that modulate the activity of this enzyme using a combination of AI based virtual screening, activity assays, and high throughput x-ray crystallography on the ESRF MX beamlines.
Expected profile
Degree allowing enrollment for a PhD (such as MSc, Master 2 de Recherche, Laurea or equivalent) in biophysics, biology or physics Background in structural biology is desirable Ability to interact within a multi-disciplinary team Proficiency in English (working language at the ESRF)
Working conditions
The salary will be calculated on the basis of relevant qualifications and professional experience.
Do you recognize yourself in this description? Apply now for your next professional adventure
What we offer:
Join an innovative international research institute, with a workforce from 38 different countries Collaborate with global experts to advance science and address societal challenges Come and live in a vibrant city , in the heart of the Alps, and Europe's Green Capital 2022 Enjoy a workplace designed to support your quality of life Benefit from our competitive compensation and allowances package , including financial support for your relocation to Grenoble-
PhD Thesis Student on ID30B in the Structural Biology group
il y a 1 semaine
Grenoble, France ESRF Temps pleinContext & Job description Thesis subject: Design and Engineering of Artificial Enzymes for green Energy The project will combine protein chemistry and structural studies to develop “green” catalysts for protons and CO2 reductions into energy-dense organic chemicals, crucial to store renewable intermittent energies (e.g. solar energy) in...
-
PhD Thesis Student on ID14 LECOR
il y a 4 semaines
Grenoble, France ESRF Temps pleinContext & Job description Subject: Elastic and plastic properties of iron alloys at extreme conditions You will join the team of the Nuclear Resonance Scattering (ID14) beamline composed of 7 people and perform the research within the ERC-funded project LECOR (Light Elements in the Core). The project is aimed to refine compositional models of the...
-
PhD Student on ID03 in the Structure of Materials group
il y a 5 jours
Grenoble, France ESRF Temps pleinContext & Job description Thesis subject: Advanced 3D Characterization of Deformed and Recrystallized Microstructures in Highly Strained Metals As a PhD student, you will play a crucial role in the investigation of the connection between deformation and annealing microstructures in metals, addressing the challenge of mapping deformed and...
-
PhD Student on ID22 in the Structure of Materials group
il y a 2 semaines
Grenoble, France ESRF Temps pleinContext & Job description Thesis subject: Enhanced carbon dioxide reforming of methane using combined zeolite catalysts You will join the ID22 team at the ESRF. ID22 is a versatile instrument that can be exploited for a wide range of high-resolution powder diffraction measurements. The PhD project is in relation with the study and efficiency...
-
PhD Thesis Student
il y a 4 semaines
Grenoble, France ESRF Temps pleinContext & Job description Subject: Probing protein dynamics by single-crystal room temperature, or high-pressure cryogenic, crystallography and in crystallo optical spectroscopy You will join the Structural Biology Group to pursue a project aimed to propose a new paradigm in macromolecular crystallography (MX) by focusing on room temperature data...
-
PhD Thesis Student
il y a 3 semaines
Grenoble, France ESRF Temps pleinContext & Job description Thesis subject : Synchrotron nano-imaging informed tailoring of additive manufacturing microstructures against strain localization BeamlineID16B is dedicated to hard X-ray nano-analysis, combining X-ray fluorescence (XRF), X-ray absorption spectroscopy (XAS), X-ray excited optical luminescence (XEOL), X-ray diffraction...
-
Physics Teacher in Grenoble
il y a 2 semaines
Grenoble, France UniProf Temps pleinWe are hiring! UniProf is looking for French Physics teachers who offer face-to-face lessons to French university students in Grenoble. **What is UniProf?** **Your profile**: - Experience in teaching; - Basic computer skills (Microsoft Office, Skype, Google). **Your tasks** As a teacher, you will have the following responsibilities: - Help students...
-
Phd Grant Proposal
il y a 2 semaines
Grenoble, Auvergne-Rhône-Alpes, France CEA Temps pleinPosition descriptionCategory: Biology, biophysics and biochemistryContract: Fixedterm contractJob title: PhD grant proposal H/FSocio-professional category: ExecutiveContract duration (months): 36Job description: Key words: pancreatic cancer, organonchip, diabetes, microfluidics Pancreas is an amphicrine gland with and endocrine function that regulates the...
-
Phd Grant Proposal
il y a 2 semaines
Grenoble, Auvergne-Rhône-Alpes, France CEA - Commissariat à l'Energie Atomique Temps pleinGeneral information:Organisation :The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas:defence and security,- nuclear energy (fission and fusion),- technological research for industry,- fundamental research in the physical sciences and life sciences.Drawing on its widely...
-
PhD student
il y a 3 jours
Grenoble, France ESRF Temps pleinContext & Job description The characterization of structural properties such as displacement fields, composition, and defects in nanostructures is a major challenge in materials science, particularly in catalysis. Copper (Cu) is gaining attention as a viable alternative to precious transition metals like platinum (Pt), palladium (Pd), and rhodium (Rh)...
-
Analyse Mathématique de La Génération de Seconde
il y a 2 semaines
Grenoble, France Université Grenoble Alpes Temps plein**Analyse mathématique de la génération de seconde harmonique en électromagnétisme // Mathematical analysis of second harmonic generation**: - Réf **ABG-124225** **ADUM-57800** - Sujet de Thèse- 28/05/2024- Université Grenoble Alpes- Lieu de travail- Grenoble Cedex 9 - France- Intitulé du sujet- Analyse mathématique de la génération de seconde...
-
Irga Phd Student Id16b
il y a 2 semaines
Grenoble, Auvergne-Rhône-Alpes, France ESRF Temps plein**Context & Job description**Sujet de thèse: Conception informée par nano-tomographie synchrotron de microstructures de fabrication additive délocalisantes***La ligne de lumière ID16B dédiée à la nano-analyse par rayons X durs, combine ainsi les techniques de fluorescence par rayons X, de spectroscopie d'absorption par rayons X, de diffraction et...
-
PhD Student
il y a 1 semaine
Grenoble, France ESRF Temps pleinContext & Job description Thesis subject: Hybrid physics- and data-driven methods for X-ray fluorescence computed tomography (XRFCT) Scientific context and motivation X-ray fluorescence CT (XRFCT) is based on the analysis of the fluorescence signal of a sample excited by a thin X-ray pencil beam. It has several applications in the fields of...
-
Grenoble, Auvergne-Rhône-Alpes, France Swansea University Temps pleinFunding providers: Swansea University Strategic Partnership Research Scholarships (SUSPRS) with Université Grenoble Alpes, FranceSubject areas: Coastal EngineeringProject start date: 1 October 2024 (Enrolment open from mid-September)Project description: This is a joint PhD programme between Swansea University and Université Grenoble Alpes.Sand bars are a...
-
Irga Phd Student Id16b
il y a 3 semaines
Grenoble, France ESRF Temps plein**Context & Job description** Sujet de thèse: Conception informée par nano-tomographie synchrotron de microstructures de fabrication additive délocalisantes*** La ligne de lumière ID16B dédiée à la nano-analyse par rayons X durs, combine ainsi les techniques de fluorescence par rayons X, de spectroscopie d’absorption par rayons X, de diffraction et...
-
Multimodal Llms
il y a 4 semaines
Grenoble, France NAVER LABS Europe Temps pleinMultimodality, in particular the incorporation of speech representations into LLMs, enables systems to comprehend and respond to spoken language with unparalleled accuracy and depth. Different methods for fusion have been explored recently, ranging from shallow fusion through discrete speech units modeling [1,2] to more complex approaches for integrating...
-
Grenoble, Auvergne-Rhône-Alpes, France Institut pour l'avancée des Biosciences -Centre de Recherche UGA Inserm U 1209 CNRS UMR 5309 Temps plein2 Dec 2023Job Information Organisation/CompanyInstitut pour l'avancée des Biosciences -Centre de Recherche UGA / Inserm U 1209 / CNRS UMR 5309Research FieldBiological sciences » BiologyResearcher ProfileRecognised Researcher (R2)Leading Researcher (R4)First Stage Researcher (R1)Established Researcher (R3)CountryFranceApplication Deadline29 Mar 2024 –...
-
Retrieval Augmented Generation
il y a 5 jours
Grenoble, France NAVER LABS Europe Temps pleinWe are looking for students who are interested in working on retrieval augmented generation (RAG). Based on a simple idea of augmenting user requests with relevant passages retrieved from the Internet or a given collection, RAG has recently emerged as a promising solution for incorporating recent or domain-specific knowledge into LLMs and improving LLM...
-
Extracting Composition and Texture of Ancient
il y a 2 semaines
Grenoble, Auvergne-Rhône-Alpes, France Idex université Grenoble Alpes Temps pleinExtracting composition and texture of ancient pigments from modeling of their spectral reflectance:Réf- ABG-114225 Sujet de Thèse 07/05/2023 Contrat doctoral Idex université Grenoble Alpes Lieu de travail Grenoble Auvergne-RhôneAlpes France Intitulé du sujet Extracting composition and texture of ancient pigments from modeling of their spectral...
-
Dense and Unconstrained Stereo 3D Reconstruction of
il y a 5 jours
Grenoble, France NAVER LABS Europe Temps pleinDUSt3R, a novel paradigm for Dense and Unconstrained Stereo 3D Reconstruction, has shown impressive and encouraging results. It casts the pairwise reconstruction problem as a regression of pointmaps, relaxing the hard constraints of the usual projective camera model. It performs well on static urban or interior scenes, and can predict realistic pointmaps...