PhD Thesis Student

il y a 5 jours


Grenoble, France ESRF Temps plein

Context & Job description

Thesis subject: Exotoxin A from Pseudomonas aeruginosa at MASSIF-1: fragment screening in the era of Artificial Intelligence

Pseudomonas aeruginosa is human pathogen which has been classified by the World Health Organisation as one of the three highest priority antibiotic-resistant bacterias. It is one of the leading causes of hospital-acquired-infections and was responsible for more than half a million deaths in 2019. Central to its virulence exotoxin A protein, which inactivates the host cell translational machinery leading to cell death. In this Ph.D., the successful candidate will identify compounds that modulate the activity of this enzyme using a combination of AI based virtual screening, activity assays, and high throughput x-ray crystallography on the ESRF MX beamlines.

Expected profile

Degree allowing enrollment for a PhD (such as MSc, Master 2 de Recherche, Laurea or equivalent) in biophysics, biology or physics Background in structural biology is desirable Ability to interact within a multi-disciplinary team Proficiency in English (working language at the ESRF)

Working conditions

The salary will be calculated on the basis of relevant qualifications and professional experience.

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What we offer:

Join an innovative international research institute, with a workforce from 38 different countries Collaborate with global experts to advance science and address societal challenges Come and live in a vibrant city , in the heart of the Alps, and Europe's Green Capital 2022 Enjoy a workplace designed to support your quality of life Benefit from our  competitive compensation and allowances package , including financial support for your relocation to Grenoble

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