Development of Molecular and Cellular Tools for The
il y a 2 semaines
**Development of molecular and cellular tools for the study of phytocannabinoid mechanisms in the skin**:
- Réf
- **ABG-111840**
- Sujet de Thèse- 08/03/2023- Contrat doctoral- Centre de Biophysique Moléculaire UPR4301 CNRS- Lieu de travail- Orléans - Centre Val de Loire - France- Intitulé du sujet- Development of molecular and cellular tools for the study of phytocannabinoid mechanisms in the skin- Champs scientifiques- Biologie
- Mots clés- Skin cells, endocannabinoid system, phytocannabinoïds, receptors, dermocosmetic**Description du sujet**:
- The objective of this thesis project is to develop cellular and molecular tools to study the pharmacological effects of phytocannabinoids to better understand their mode of action on the endocannabinoid system of the skin. Two types of models will be developed: 1/ the extinction of receptors in skin cells, 2/ the overexpression of these receptors. These models will then be characterized by monitoring the receptor expression and by studying their functionality. These different established models will make it possible to undertake pharmacological studies and also to investigate the mechanisms of action of different phytocannabinoids that will have been selected as interesting active ingredients for skin care.-
- L’objectif de ce projet de thèse est de développer des outils cellulaires et moléculaires pour étudier les effets pharmacologiques et les activités des phytocannabinoïdes pour mieux comprendre leur mode d’action sur le système endocannabinoïde de la peau. Deux types de modèles seront mis au point : 1/ l’extinction de certains récepteurs dans les cellules cutanées, 2/ la surexpression de ces. Ces modèles seront ensuite caractérisés par le suivi de l’expression des récepteurs et, le cas échéant, l’étude de leur fonctionnalité. Ces différents modèles établis permettront d’entreprendre des études pharmacologiques et d’investiguer les mécanismes d’action de différents phytocannabinoïdes qui auront été sélectionnés comme actifs intéressants pour les soins de la peau.**Prise de fonction**:
- 01/10/2023**Nature du financement**:
- Contrat doctoral**Précisions sur le financement**:
- sur concours de l'Ecole Doctorale SSBV**Présentation établissement et labo d'accueil**:
- Centre de Biophysique Moléculaire UPR4301 CNRSThe Centre for Molecular Biophysics is a multidisciplinary laboratory allowing the developement of research at the frontier between biology, physics and chemistry. Our team works on the importance of microenvironment on cell activities. In the skin area, we are interested in mecanisms regulated by oxygen level, and in particular in the consequenes of skin aging/photaging (pigmentation, oxydative stress,...). We work in collaboration with industrial partners in the field of dermocosmetic and we belong to the CNRS research network GDR Cosmactifs.
Le Centre de Biophysique Moléculaire - UPR4301 CNRS - est un laboratoire pluridisciplinaire permettant de développer des recherches à la frontière de la biologie, la physique et la chimie. Le travail de notre groupe est focalisé sur l’importance du microenvironnement dans les activités cellulaires. Dans le domaine de la peau, nous nous intéressons aux mécanismes qui sont régulés par le taux d’oxygénation, et particulièrement aux conséquences du photovieillissement (pigmentation, stress oxydant, ). Nous avons plusieurs collaborations avec des partenaires industriels dans le domaine de la cosmétique et participons au Groupement de Recherche CNRS GDR Cosm’actifs
**Site web**:
**Etablissement délivrant le doctorat**:
- Université Orléans- Required qualities: rigor and seriousness, organization and autonomy, ability to work in a team, good communication skills, good command of scientific English, both oral and writtenDes connaissances en biologie cutanée et /ou une première expérience en culture cellulaire et/ou construction de plasmides seraient appréciées
Candidat avec rigueur et sérieux, organisation et autonomie, aptitude au travail en équipe, bonne communication, bonne maitrise de l’anglais scientifique à l’oral et à l’écrit- 03/04/2023
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