![Centre de recherche en cancérologie de Marseille](https://media.trabajo.org/img/noimg.jpg)
Role of The Epigenetic Enzyme Ezh2 in Leukemia
il y a 3 semaines
**Role of the epigenetic enzyme EZH2 in leukemia resistance**:
- Réf **ABG-124603**
- Stage master 2 / Ingénieur- Durée 6 mois- Salaire net mensuel sur grille salaire INSERM- 13/06/2024- Centre de recherche en cancérologie de Marseille- Lieu de travail- Marseille Provence-Alpes-Côte d'Azur France- Champs scientifiques- Biologie
- Mots clés- Leukemia, Epigenetics, Resistance**Établissement recruteur**:
**Site web**:
**Research focus of the team**
The main scientific objective of the team is to decipher the transcriptional and epigenetic networks involved in the regulation of proliferation _versus _differentiation of normal or pathological hematopoietic cells. We are interested in the epigenetic mechanisms related to age-related deregulation of hematopoiesis. In parallel, we develop a more applied research in collaboration with the clinicians of the Paoli-Calmettes Institute, using epigenomics and single-cell state-of-the-art techniques for acute myeloid leukemia (AML), in order to improve its management. Altogether, our scientific activity is mainly focused on the following keywords: AML, therapy resistance, hematopoietic stem cell, epigenetics, aging, single cell technologies.
**Description**:
**Master 2 project**:
Context. Resistance to anti-cancer therapeutics remains one of major obstacles to improving survival rates in cancer; it arises in a multitude of ways including accumulation of epigenetic alterations. Recently, we discovered a new mechanism of treatment resistance that is not fully driven by epigenetic remodeling but nevertheless implies an activity switch of an epigenetic enzyme, EZH2. Despite its well-established activity as part of PRC2 for mediating gene repression by H3K27me3 deposition, new evidence points the importance of others, so-called non-canonical activities. In line with this, we revealed that non-canonical EZH2 activity was associated with therapy resistance in acute myeloid leukemia (AML) (Poplineau et al., Blood 2022). However, our current knowledge of how and which non-canonical activity of EZH2 participates to this process is still poorly understood. One of our hypotheses is that EZH2 posttranslational modifications (PTMs) would affect EZH2 activity and impact treatment response. By coupling, proteomics, gene editing, epigenomics and transcriptomics approaches using AML cell line resistant to chemotherapy we aim to identify and functionally characterize EZH2 PTMs. We will monitor their repercussion at the chromatin and transcriptional levels and study their impact on therapy response. In parallel, we aim to evaluate, in preclinical models of AML, the therapeutic interest of targeting EZH2 non-canonical activity using an EZH2 PROTAC. We believe that EZH2 degradation will clear the therapy-resistant cells and/or lead to a transcriptomic reprogramming of these cells towards less aggressive cells. We hope to define AML conditions that will benefit the use of EZH2 degrader, opening new therapeutic opportunity for patients with high risk of relapse.
**Profil**:
**Prise de fonction**:
- 06/01/2025
-
Role of Foxk1 in T Cell Leukemia
il y a 2 semaines
Marseille, France Centre d'Immunologie de Marseille Luminy (CIML) Temps plein**Role of Foxk1 in T cell leukemia**: - Réf **ABG-121896** - Sujet de Thèse- 27/03/2024- Contrat doctoral- Centre d'Immunologie de Marseille Luminy (CIML)- Lieu de travail- Marseille - Provence-Alpes-Côte d'Azur - France- Intitulé du sujet- Role of Foxk1 in T cell leukemia- Champs scientifiques- Biologie - Mots clés- T cell Signaling;...
-
Novel Chemical Tools to Study The Role of
il y a 2 jours
Marseille, France AMU Institut de chimie radicalaire Temps plein**Novel chemical tools to study the role of mitochondrial superoxide in cancer cell death**: - Réf **ABG-123668** - Sujet de Thèse- 04/05/2024- Autre financement public- AMU Institut de chimie radicalaire- Lieu de travail- Marseille - Provence-Alpes-Côte d'Azur - France- Intitulé du sujet- Novel chemical tools to study the role of mitochondrial...
-
Advanced Photonic Methods for The Operando Studies
il y a 7 jours
Marseille, France Bioenergetics and Protein Engineering Laboratory Temps plein**Advanced photonic methods for the operando studies of electro-enzymatic catalysis at the electrodes of H2/O2 bio-fuel cells**: - Réf **ABG-123548** - Sujet de Thèse- 30/04/2024- Contrat doctoral- Bioenergetics and Protein Engineering Laboratory- Lieu de travail- Marseille - Provence-Alpes-Côte d'Azur - France- Intitulé du sujet- Advanced photonic...
-
Mieux Comprendre Et Exploiter Le Ciblage de Cdk6
il y a 2 semaines
Marseille 9e, France Aix Marseille Université Temps plein**Mieux comprendre et exploiter le ciblage de CDK6 dans les hémopathies. // Understand and exploit CDK6 targeting in hematological disorders**: - Réf **ABG-121576** **ADUM-54257** - Sujet de Thèse- 22/03/2024- Contrat doctoral- Aix Marseille Université- Lieu de travail- Marseille Cedex 09 - France- Intitulé du sujet- Mieux comprendre et exploiter le...
-
The Transcriptional Control of Obesity Using
il y a 2 semaines
Marseille, France Marseille Institute of Developmental Biology (IBDM) Temps plein**The transcriptional control of obesity using Drosophila as model**: - Réf **ABG-123953** - Sujet de Thèse- 17/05/2024- Financement public/privé- Marseille Institute of Developmental Biology (IBDM)- Lieu de travail- Marseille - Provence-Alpes-Côte d'Azur - France- Intitulé du sujet- The transcriptional control of obesity using Drosophila as model-...
-
Part Time Babysitting Roles in Marseille English
il y a 4 semaines
Marseille, France NouNouLangues Temps plein** Part-time roles for english speakers working with children in the Marseille / Aix en Provence area starting in September** NouNouLangues are looking for fluent English speakers for various childcare roles starting in September around Marseille and Aix en Provence, We have part time hours ranging from 5-20h per week, ideally you are able to commit to the...
-
Part Time Babysitting Roles in Marseille English
il y a 4 jours
Marseille, France NouNouLangues Temps plein** Part-time roles for english speakers working with children in the Marseille / Aix en Provence area starting in September 2024** NouNouLangues are looking for fluent English speakers for various childcare roles starting in September around Marseille and Aix en Provence, We have part time hours ranging from 5-20h per week, ideally you are able to commit to...
-
Physicist of Turbulent Transport in
il y a 7 jours
Marseille, France CEA Temps pleinDescription du poste **Domaine**: - Physique théorique **Contrat**: - CDD **Intitulé de l'offre**: - Physicist of turbulent transport in stellarator-like configurations M/F **Statut du poste**: - Cadre **Durée du contrat (en mois)**: - 36 **Description de l'offre**: - The objective of the position is to address turbulent transport issues in...
-
Analysis of The Non-linear Interaction Between
il y a 7 jours
Marseille, France CEA - Commissariat à l'Energie Atomique Temps plein**Domaine**: Physique du noyau, atome, molécule **Contrat**: Stage **Intitulé de l'offre**: Analysis of the non-linear interaction between plasma turbulence and plasma-neutrals interaction in H/F **Sujet de stage**: This internship project aims at exploiting edge plasma turbulence simulations with the SOLEDGE3X-EIRENE boundary plasma fluid code to...
-
Modelling of The Boundary Plasma During The
il y a 7 jours
Marseille, France CEA - Commissariat à l'Energie Atomique Temps plein**Domaine**: Physique du noyau, atome, molécule **Contrat**: Stage **Intitulé de l'offre**: Modelling of the boundary plasma during the start-up phase of ITER discharges H/F **Sujet de stage**: This internship project aims at adapting and using the SOLEDGE3X-EIRENE boundary plasma simulation code to analyse the start-up phase of ITER discharges when the...
-
Electroenzymatic Biosensor for H2 Detection
il y a 2 semaines
Marseille, France CNRS Temps plein**Electroenzymatic biosensor for H2 detection**: - Réf **ABG-123384** - Sujet de Thèse- 24/04/2024- Autre financement public- CNRS- Lieu de travail- Marseille - Provence-Alpes-Côte d'Azur - France- Intitulé du sujet- Electroenzymatic biosensor for H2 detection- Champs scientifiques- Chimie - Biotechnologie - Mots clés- Biosensor, enzyme, hydrogen,...
-
Mechanistic Learning of The Natural History of Lung
il y a 7 jours
Marseille, France Inria Temps pleinLe descriptif de l’offre ci-dessous est en Anglais_ **Niveau de diplôme exigé **:Bac + 5 ou équivalent **Fonction **:Stagiaire de l'ingénierie **Niveau d'expérience souhaité **:Jeune diplômé **A propos du centre ou de la direction fonctionnelle**: The Inria centre at Université Côte d'Azur includes 42 research teams and 9 support services....
-
Head of Financial Crime
il y a 1 mois
Marseille, France Selby Jennings Temps pleinIn this role you will be focused on and responsible for ensuring that the Financial Crime Team has a strong and effective oversight and management of Anti-Bribery and Corruption (AB&C), Tax Evasion and Anti-Money Laundering-Terrorist Financing (AML-TF) (also known as “specialist areas”) requirements across the European legal entity perimeter.This role...
-
Mechanistic learning of the natural history of lung cancer
il y a 3 jours
Marseille, France INRIA Temps pleinContexte et atouts du poste This PhD position will take place in the environment of the Inria-Inserm team COMPO (COMputational Pharmacology in Oncology), located in the La Timone health campus. The team is composed of mathematicians, data scientists, pharmacists and clinicians and is a unique multidisciplinary environment focused on developing novel...
-
Experimental Study of The Pyrolysis and Flame
il y a 2 semaines
Marseille, France IRSN Temps plein**Intitulé du poste**: Experimental study of the pyrolysis and flame spread on horizontal fuel panels (PsD RES23-01) H/F **Type de contrat**: Post-doctorat **Statut**: Cadre **Disponibilité du poste**: 01/06/2024 **Localisation du poste**: Cadarache **Environnement / Organisation / Contexte**: Electrical cables are one of the main fire hazards in many...
-
Food and Beverage Supervisor to Work in Ireland
il y a 4 semaines
Marseille, France The iNUA Collection Temps pleinAs Ireland’s largest regional hotel group, The iNUA Collection includes beautiful 4 and 5 Star Hotels across the island of Ireland. Our Irish-owned collection stretches from Cork to Sligo, Killarney to Monaghan, Athlone, Kilkenny, Limerick, Dundalk, Dublin and Tullamore. We are now looking for someone with a strong background in **Food & Beverage** and a...
-
Study of The Photochemical and Electron-beam
il y a 2 semaines
Marseille, France Isabelle Couturier Temps plein**Study of the photochemical and electron-beam evolution of Titan's atmospheric ices**: - Réf **ABG-121696** - Sujet de Thèse- 22/03/2024- Autre financement public- Isabelle Couturier- Lieu de travail- MARSEILLE - Provence-Alpes-Côte d'Azur - France- Intitulé du sujet- Study of the photochemical and electron-beam evolution of Titan's atmospheric ices-...
-
Iodine Fate in Atmospheric Droplets: Heterogeneous
il y a 3 semaines
Marseille, France Institut de Radioprotection et de Sûreté Nucléaire Temps plein**IODINE FATE IN ATMOSPHERIC DROPLETS: HETEROGENEOUS REACTIVITY AND ROLE OF INTERFACE**: - Réf - **ABG-113442** - Sujet de Thèse- 14/04/2023- Contrat doctoral- Institut de Radioprotection et de Sûreté Nucléaire- Lieu de travail- Cadarache - Provence-Alpes-Côte d'Azur - France- Intitulé du sujet- IODINE FATE IN ATMOSPHERIC DROPLETS: HETEROGENEOUS...
-
Head of Enterprise Architecture
il y a 4 jours
Marseille, France Ceva Logistics Temps pleinCEVA Logistics provides global supply chain solutions to connect people, products and providers all around the world. Present in 170 countries and with more than 110,000 employees spread over 1,300 sites, we are well on our way to achieving our vision: to be a Top 5 global 3PL. We believe that our employees are the key to our success. We want to engage and...
-
Head of Enterprise Architecture
il y a 4 jours
Marseille, France Ceva Logistics Temps pleinCEVA Logistics provides global supply chain solutions to connect people, products and providers all around the world. Present in 170 countries and with more than 110,000 employees spread over 1,300 sites, we are well on our way to achieving our vision: to be a Top 5 global 3PL._ - We believe that our employees are the key to our success. We want to engage...