Stabilization of Pickering Emulsions By Association
il y a 4 semaines
**Stabilization of Pickering emulsions by association of biodegradable and biocompatible polymer particles**:
- Réf **ABG-123460**
- Sujet de Thèse- 26/04/2024- Contrat doctoral- Laboratoire d’Automatique, de Génie des Procédés et de Génie Pharmaceutique (LAGEPP), Lyon- Lieu de travail- Villeurbanne - Auvergne-Rhône-Alpes - France- Intitulé du sujet- Stabilization of Pickering emulsions by association of biodegradable and biocompatible polymer particles- Champs scientifiques- Chimie
**Description du sujet**:
- To continue this project, we want to formulate **neutral, anionic and cationic biodegradable and biocompatible polymer nanoparticles and microparticles**. Once again, **two types of polymer particles** will be used to stabilize the emulsion and to encapsulate two different active ingredients. The aim is to examine **the differences in behaviour between emulsions prepared using nanoparticles and those obtained using microparticles**, and to propose **a biodegradable and biocompatible vector for the simultaneous and controlled topical delivery of two active ingredients**.- Detailed description of the project:
To complete this project, **three types of biodegradable and biocompatible polymer nanoparticles and microparticles** (neutral, anionic and cationic) will first have to be developed. The size and surface charges of these objects will have to be controlled. Secondly, and following on from the work carried out at LAGEPP [6], the approach will involve using microparticles alone or in a binary mixture to stabilize emulsions. **Fluorescent microparticles** will be prepared to be observed by confocal fluorescence microscopy. Adsorption at the interfaces of the microparticles will be related to the stability of the emulsions. The results will be compared with those previously obtained with biocompatible microparticles (Figure 1). The characteristics (size, stability) of **emulsions stabilized with nanoparticles (alone or in a binary mixture)** will then be studied in order to highlight differences in behaviour compared with the use of microparticles as stabilizers.
- Another fundamental aspect is **the experimental study of the transfer of active ingredients within the emulsion**. In a final step, we will use two active ingredients which will be co-encapsulated in the emulsion (the stabilizing systems used will be defined according to the results obtained previously). The aim will be to understand the various mass transfers from the core of the microparticles to that of the emulsion droplets or into the continuous phase. These transfer phenomena would modify the location of the active ingredients within the emulsion and could therefore have an impact on the bioavailability of the active ingredient. The aim of this stage of the study is to see whether it would be **possible to deliver in a differentiated way several active ingredients** with different biological targets.- Finally, the **optimal emulsions** will be tested for **cutaneous administration of two active ingredients**. Their penetration will be determined experimentally _in vitro_ in metabolically inactive pig skin explants using Franz diffusion cells. Penetration will be monitored in the different layers of the skin: the epidermis, whose superficial layer is the _stratum corneum_, the dermis and the hypodermis. The aim is to validate **the possibility of targeting a specific skin layer by the active ingredients**.**This study will provide knowledge of the stabilization mechanisms of Pickering emulsions and develop formulations of interest capable of delivering several active ingredients in a targeted manner.**
- [1] Chevalier Y., Bolzinger M.A., _Emulsions stabilized with solid nanoparticles: Pickering emulsions_, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 439, 23-34, 2013- [2] Frelichowska J., Bolzinger M.A., Valour J.P., Mouaziz H., Pelletier J., Chevalier Y., _Pickering w/o emulsions: Drug release and topical delivery_, International Journal of Pharmaceutics, 368 (1-2), 7-15, 2009- [3] Frelichowska J., Bolzinger M.A., Pelletier J., Valour J.P., Chevalier Y., _Topical delivery of lipophilic drugs from o/w Pickering emulsions,_ International Journal of Pharmaceutics, 371 (1-2), 56-63, 2009- [4] Laredj-Bourezg F., Chevalier Y., Bolzinger M.A., _Skin delivery of hydrophobic drugs using biocompatible and biodegradable carriers: Pickering emulsions and block copolymer nanoparticles. Correlation to drug localization within the skin layers as determined by confocal fluorescence microscopy_, Experimental Dermatology, 21 (9), 2012- [5] Laredj-Bourezg F., Bolzinger M.A., Pelletier J., Chevalier Y., _Pickering emulsions stabilized by biodegradable block copolymer micelles for controlled topical drug delivery_, International Journal of Pharmaceutics, 531 (1), 134-142, 2017- [6] Benyaya M., Bolzinger M.A., Chevalier Y., Ensenat S., Bordes C., _Pickering_ e_mulsions stabilized with differently charged particles_, Soft Mat
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