Synthesis of Antibacterial and Thermoresponsive
Il y a 2 mois
**Synthesis of antibacterial and thermoresponsive polymers used as coatings for the release of a healing agent on chronic wounds**:
- Réf
- **ABG-111539**
- Sujet de Thèse- 28/02/2023- Autre financement public- CNRS - Institut Charles Sadron- Lieu de travail- Strasbourg - Grand Est - France- Intitulé du sujet- Synthesis of antibacterial and thermoresponsive polymers used as coatings for the release of a healing agent on chronic wounds- Champs scientifiques- Chimie
- Mots clés- Peptide, polymer, biomaterials**Description du sujet**:
The World Health Organization continues to alert the health sector to the emergence and proliferation of multiresistant microbial strains to antibiotics. In Europe, one in twenty patients will contract a nosocomial infection
during their hospitalization, representing the sixth leading cause of death in hospitals. As an alternative to the
administration of antibiotics, strategies to control nosocomial infections must be implemented involving the
discovery of new antimicrobial agents and the use of adapted modes of administration.
We have synthesized poly(methacrylate-g-oligoarginine)s which exhibit an unexpected upper critical solution
temperature (UCST) behavior, i.e. transition from insoluble to soluble upon increasing the temperature. This phenomenon is totally reversible allowing the formation of 200 nm aggregates at room
temperature, that are able to encapsulate bioactive molecules, and their dissolution at 37 °C or above (Eur.
Polym. J. 2020, 125, 109528). Moreover, the decaarginine-based macromolecules showed antibacterial
properties against Staphyloccocus aureus (S. aureus), one of the most virulent bacteria.
The objective of the doctoral work is to (i) synthesize antibacterial and thermoresponsive decaarginine-based
polymers of different topologies and (ii) to evaluate their biocompatibility in contact with human cells and
their antibacterial properties in collaboration with INSERM UMR 1121 (Strasbourg).
**Prise de fonction**:
- 01/09/2023**Nature du financement**:
- Autre financement public**Précisions sur le financement**:
- ANR**Présentation établissement et labo d'accueil**:
- CNRS - Institut Charles SadronThe Charles Sadron Institute (ICS, UPR22) is a CNRS unit associated with the University of Strasbourg. This multidisciplinary institute dedicated to the science of polymers and self-assembled systems includes 49 researchers, 34 research support staff and 100 non-permanent staff (PhD students, postdocs and interns). The ICS has characterization platforms (UV-Vis and IR spectroscopies, steric exclusion chromatography, light scattering, etc.) and microscopy (electron and atomic force). Supervised by Delphine Chan-Seng and Fouzia Boulmedais, the PhD student will work in the ICS team Polyelectrolytes, Complexes and Materials.
**Site web**:
**Intitulé du doctorat**:
- Chimie organique**Pays d'obtention du doctorat**:
- France**Etablissement délivrant le doctorat**:
- UNIVERSITE DE STRASBOURG**Ecole doctorale**:
- Sciences chimiquesprofile in molecular chemistry (organic synthesis, purification, and characterization of organic compounds)
interesting in strengthening his/her skills in polymer chemistry and in working on a project at the interface of
chemistry and biology. A previous experience in peptide synthesis, polymer synthesis or physical chemistry of
polymers would be appreciated. No skills in biology are requested.- 28/04/2023
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