Development of Fluorinated Cathepsin D Inhibitors
Il y a 3 mois
**Development of fluorinated Cathepsin D inhibitors as potential PET tracers for breast cancer imaging**:
- Réf **ABG-125952**
- Stage master 2 / Ingénieur- Durée 6 mois- Salaire net mensuel /- 24/09/2024- CY Cergy Paris University - Laboratory BioCIS- Lieu de travail- Neuville sur Oise Ile-de-France France- Champs scientifiques- Chimie
- Biochimie
- Mots clés- Chemistry, Organic Synthesis, PET, radiotracers, Fluorination, Last step fluorination, Cathepsin D, M2, Peptides-
- 01/12/2024**Établissement recruteur**:
**Site web**:
BioCIS team brings together researchers on the general theme of chemistry oriented towards the life sciences. We study the synthesis, characterization and evaluation of biomolecules, as well as the development of new synthetic methodologies.
The skills of the team members include, among others, the chemistry of organofluorine compounds and glycosides, organometallic chemistry, asymmetric synthesis, solid surface synthesis of peptides, structural and biophysical analyses.
**Description**:
Institution: CY Cergy Paris University
Research Unit: BioCIS, Team ECB - Equipe de Chimie Biologique - UMR-CNRS-8076
Supervisor: Dr Chiara ZANATO and Dr Evelyne CHELAIN
Period: January 2024 - July 2024 (6 months)
Funding: CY Initiative 2023 - EMERGENCE Program
Application Deadline: Until filled
Context and Project Objectives
Cathepsin D (CD) is a lysosomal aspartyl protease responsible for intracellular protein degradation, autophagy, and immune response.[1] Significantly, CD deregulation can contribute to several human diseases.[2] High extracellular levels of CD were observed in cancers and, in particular, are statistically associated with poor prognosis triple-negative breast cancer.[3] In light of that, CD could act as a diagnostic biomarker for this pathology. Positron Emission Tomography (PET),[4] a non-invasive imaging technique that detects the gamma rays from positron-emitting isotopes, has gained a significant impact on the diagnosis and treatment of breast cancer (BC).[5] This project aims to design, synthesise and characterise [18F]-radiolabelled PET tracers targeting CD. These new radioligands will allow the selective in vitro and in vivo imaging of CD and represent a new potential tool for the prognosis, diagnosis, and monitoring of BC.
**Job Description**:
References:
[1] T. Yadati et al., Cells 2020, 9, 1679.
[2] O. Mijanovic et al., Pharmaceutics 2021, 13, 837.
[3] Y. Ashraf et al., J Immunother Cancer 2019, 7, 29.
[4] U. Kumar et al., J Med Phys. 2006, 31, 13.
[5] Y. Ming et al., Frontiers in Oncology 2020, 10.
**Profil**:
**Prise de fonction**:
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